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Application of high speed centrifugation separation technology in traditional Chinese medicine extraction

A high-speed centrifugation and separation technology, which is applied to the separation of sediments, medical preparations containing active ingredients, and pharmaceutical formulas by centrifugal force, can solve the problems of long time consumption, large loss of components, and low production efficiency, and achieves difficult separation. Layer, high extraction rate, the effect of reducing production cost

Inactive Publication Date: 2013-03-20
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In traditional extraction methods, solvent extraction, precipitation, filtration, dialysis and other methods are often used to remove insoluble impurities. However, using these methods to separate impurities will result in a large loss of active ingredients, long time-consuming, low production efficiency, and high cost.

Method used

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  • Application of high speed centrifugation separation technology in traditional Chinese medicine extraction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Application of high-speed centrifugation method in the preparation of polysaccharide drug extract

[0032] The determination of the content of polysaccharide refers to the determination of the content under the detection item of Polygonatum Part II of "The Veterinary Code of the People's Republic of China". The glucose standard curve method is used, and the anhydrous glucose dried to constant weight at 105°C is used as the reference substance to prepare the glucose standard solution. 1. Sulfuric acid color development, measuring the absorbance of glucose solutions with different concentrations at 582nm in an ultraviolet-visible spectrophotometer, and preparing a glucose standard curve. The obtained standard curve is A=10.79315C+0.013521 (A is absorbance, C is polysaccharide concentration, unit mg / mL), wherein, R=0.9999.

[0033] When determining the polysaccharide content, accurately weigh the polysaccharide extract of traditional Chinese medicine to prepare t...

Embodiment 2

[0051] Example 2 Application of the high-speed centrifugation method of the present invention in the extraction of Chinese medicines containing flavonoids

[0052] The content of total flavonoids was determined by the rutin standard curve method, with rutin standard as the control, sodium nitrite-aluminum nitrate-sodium hydroxide was used for color development, and the absorbance was measured at 510nm to prepare the rutin standard curve. The obtained rutin standard curve is A=16.181C-0.0156 (A is absorbance, C is polysaccharide concentration, unit mg / mL), wherein, R=0.9996.

[0053] Accurately weigh the flavonoid extract of traditional Chinese medicine, prepare the test solution, add sodium nitrite, aluminum nitrate, sodium hydroxide color solution to develop color, and measure the absorbance value at 510nm. The content of total flavonoids in the solution was calculated by the standard curve of rutin, and the extraction rate of total flavonoids in traditional Chinese medicine ...

Embodiment 3

[0068] Add 16L of water (about 16 times the amount) to 1000g of Fructus Fructus Fructus Powder, and extract it ultrasonically at 50°C for 45min. The extract is collected and concentrated to an aqueous solution containing 1 g of raw medicinal material per ml. . Put the concentrated solution into a tube centrifuge and centrifuge at a speed of 15000r / min, take the supernatant, spray dry, and obtain the Fructus Fructus Fructus extract. Embodiment 3, application of the high-speed centrifugation method of the present invention in the preparation of alkaloid-containing traditional Chinese medicine extract

[0069] 1. Utilize the high-speed centrifugation method of the present invention to prepare Coptis Rhizoma extract

[0070] Coptidis rhizoma coarse powder 2kg, add 16L of 60% ethanol (about 8 times the amount), heat and reflux to extract 3 times, each time for 1h. The three extracts were combined and concentrated to an aqueous solution containing 1 g of raw medicinal material pe...

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Abstract

The invention relates an application of a high speed centrifugation separation technology in traditional Chinese medicine extraction. The application comprises: carrying out crude extraction on traditional Chinese medicine raw materials, wherein a crude extracting solution is condensed into per ml of medicine liquid containing 0.5-3 g of a clear pastet; and adopting a high speed centrifugation method to carry out centrifugation on the clear paste at a rotation speed of 10,000-20,000 r / min, taking a supernatant, and carrying out spray drying to obtain active ingredients of the traditional Chinese medicine. According to the application, the crude extraction comprises adopting reflux, boiling, cold soaking, percolation, ultrasound, microwave and other methods to carry out crude extraction on the traditional Chinese medicine raw materials, wherein the traditional Chinese medicine raw materials can be raw materials containing one or more than two active ingredients selected from a polysaccharide, flavone, saponin, anthraquinone, alkaloid, saponin, an organic acid, anthrone, coumarin, lignanoid, terpene and hemiterpene; and the high speed centrifugation method is adopted to extract the active ingredients in the traditional Chinese medicine raw materials so as to reduce production cost, shorten an extraction time, and reduce medicine ingredient loss, such that the method is a highly efficient method.

Description

technical field [0001] The invention relates to the application of a high-speed centrifugal separation technology in the extraction of traditional Chinese medicines, in particular to the application of a high-speed centrifugal separation technology in the post-extraction of traditional Chinese medicines. Background technique [0002] Today, when people advocate green health preservation, traditional Chinese medicine plays a huge role in preventing health care and treating diseases. However, due to the large volume of traditional Chinese medicine and the need to decoct before taking it, its application is limited to a certain extent. The extracted and processed traditional Chinese medicine oral liquid, granules and other extracts are very popular, not only for the treatment of human diseases, but also in animal breeding. is also widely used. [0003] The ingredients of traditional Chinese medicine are complex, their properties vary greatly, and the extraction methods are not...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K36/076A61K36/185A61K36/195A61K36/232A61K36/234A61K36/254A61K36/258A61K36/285A61K36/287A61K36/288A61K36/315A61K36/41A61K36/42A61K36/46A61K36/482A61K36/484A61K36/489A61K36/53A61K36/536A61K36/537A61K36/539A61K36/57A61K36/575A61K36/634A61K36/64A61K36/69A61K36/704A61K36/708A61K36/71A61K36/718A61K36/738A61K36/74A61K36/752A61K36/756A61K36/758A61K36/815A61K36/855A61K36/8969B01D21/26
Inventor 张许科刘兴金张晓会
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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