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Salvianolic acid A capsule and application thereof to medicine preparation

A kind of technology of salvianolic acid and capsules, applied in the field of salvianolic acid A capsules and preparation of medicines

Active Publication Date: 2013-06-12
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is still a big gap between this and the requirements of actual industrialization

Method used

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  • Salvianolic acid A capsule and application thereof to medicine preparation
  • Salvianolic acid A capsule and application thereof to medicine preparation
  • Salvianolic acid A capsule and application thereof to medicine preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0133] Take Danshen medicinal material, crush it into 4-mesh granules, add 7 times the amount of 92°C water each time, warm soak and extract 3 times, and stir at a speed of 25 rpm, warm soak and extract for 3 hours each time; the extract is concentrated under reduced pressure to relative Density 1.0-1.30 (60°C), add ethanol to make the alcohol content 70%, let it stand, filter, and recover ethanol from the filtrate under reduced pressure and concentrate until there is no alcohol smell; add water to dilute to 20mg of salvianolic acid B per 1ml, for aqueous solution 10% sodium hydroxide to adjust pH to 5.5, add 0.5% ZnCl 2As a catalyst, heat and transform at 120°C for 4 hours, adjust the pH value of the transformation liquid to 2.5 with 20% phosphoric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 3 mg of salvianolic acid A per 1 ml, and perform HPD-100 macroporous resin column chromatography For separation, the ratio of the loading amount of sal...

Embodiment 2

[0136] Take the Danshen medicinal material, crush it into particles with a diameter of about 2mm, add 9 times the amount of 95°C water each time, warm soak and extract 3 times, and stir at a speed of 30 rpm, and warm soak and extract for 2.5 hours each time; the extract is concentrated under reduced pressure to Relative density 1.0~1.30 (60°C), add ethanol to make the alcohol content 70%, let it stand, filter, the filtrate recovers ethanol under reduced pressure and concentrates until there is no alcohol smell; add water to dilute to contain salvianolic acid B15mg per 1ml, aqueous solution Adjust pH to 4.5 with 10% NaOH, add 0.5% ZnCl 2 As a catalyst, heat conversion at 120°C (0.01MPa~0.20MPa pressure) for 4 hours, adjust the pH value of the conversion liquid to 2.8 with 15% phosphoric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 5 mg of salvianolic acid A per 1 ml, and pass through HPD -100 macroporous resin column chromatography separation,...

Embodiment 3

[0139] Take Salvia miltiorrhiza, crush it into particles with a diameter of about 2mm, add 7 times the amount of 90°C water each time, warm soak and extract 3 times, and stir at a speed of 25 rpm, and warm soak and extract for 3 hours each time; the extract is concentrated under reduced pressure to Relative density 1.0~1.30 (60°C), add ethanol to make the alcohol content 70%, let it stand, filter, the filtrate recovers ethanol under reduced pressure and concentrates until there is no alcohol smell; add water to dilute to contain salvianolic acid B20mg per 1ml, aqueous solution Adjust pH to 5.5 with 10% NaOH, add 0.5% ZnCl 2 As a catalyst, heat conversion at 120°C (0.01MPa~0.20MPa pressure) for 4 hours, adjust the pH value of the conversion liquid to 2.5 with 20% phosphoric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 3 mg of salvianolic acid A per 1 ml, and pass through HPD -100 macroporous resin column chromatography separation, the ratio of...

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Abstract

The invention relates to a salvianolic acid A capsule comprising by weight 5%-60% of a salvianolic acid A composition, 94.9%-39.5% of a filler and 0.1%-0.5% of a lubricant. The salvianolic acid A composition comprises salvianolic acid A more than 93% and less than 100%, and other 4 ingredients including 0.1%-2% of alkannic acid, 0.1%-2% of rosmarinic acid, 0.1%-2% of salvianolic acid B, 0.1%-2% of salvianolic acid C. The filler is one or more selected from starch, dextrin, sucrose, mannitol, microcrystalline cellulose, pregelatinized starch and calcium sulfate. The lubricant is one or more selected from magnesium stearate, talcum powder, superfine silica powder and polyethylene glycol. The invention also discloses application of the salvianolic acid A capsule to preparation of medicine for preventing and / or treating ischemic cerebrovascular disease.

Description

technical field [0001] The invention relates to a salvianolic acid A capsule and its use in preparing medicines. technical background [0002] Cerebrovascular disease, also known as stroke, is a neurological disease caused by various causes of blood vessels supplying the brain. The main cause is cerebral arterial lumen stenosis, vasospasm, occlusion or rupture, reduced or complete blockage of blood flow, brain blood circulation and dysfunction caused by cerebral arterial system damage (such as cerebral arteriosclerosis), and brain tissue damage. A series of symptoms caused by damage. Mainly including ischemic and hemorrhagic cerebrovascular diseases. Among them (ICVD, also known as ischemic stroke) accounted for about 80%. [0003] Ischemic cerebrovascular disease refers to the degeneration, necrosis or transient loss of function of local brain tissue including nerve cells, glial cells and connecting fibers due to blood supply disturbance. Cerebral artery occlusion cause...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/216A61K31/343A61K36/537C07C69/732A61P7/02A61P9/10A61P25/00A61P25/28
Inventor 文萍罗恒真魏宇清曾发林钟阳桂刘鹏刘恩位
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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