Three-dimensional ordered porous bracket material of chitosan fiber/bioactive glass and preparation method of three-dimensional ordered porous bracket material

A bioactive glass and chitosan fiber technology, applied in the field of artificial bone repair materials, can solve the problems of lack of three-dimensional connected macroporous structure and cannot meet the mechanical strength of macroporous structure at the same time, so as to achieve good biological activity and good Effect of improving elastic modulus and mechanical strength

Inactive Publication Date: 2013-07-10
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned composite materials generally have the problem of lacking a three-dimensional connected macroporous structure, and cannot meet the requirements of having a macroporous structure and a certain mechanical strength at the same time.

Method used

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  • Three-dimensional ordered porous bracket material of chitosan fiber/bioactive glass and preparation method of three-dimensional ordered porous bracket material
  • Three-dimensional ordered porous bracket material of chitosan fiber/bioactive glass and preparation method of three-dimensional ordered porous bracket material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Preparation of chitosan fiber cloth layer:

[0032] Take the weight as 100g / m 2 The chitosan fiber is loosely mixed by hand, and is combed and loosened with a small flat carding machine; 3 pieces of fiber webs are taken, and the grammage of each piece of fiber is 550g / m 2 , Lay the web in parallel by hand, so that the fibers are arranged longitudinally; then use a needle punching machine for reinforcement, the frequency of acupuncture is 1200 punches / min, and the depth of acupuncture is 3mm, and the chitosan fiber cloth is cut into bone damage repair materials. Cut into a square with a side length of 2cm and a thickness of 3mm. The pore size of the fiber cloth is 200-300μm. Ultrasonic cleaning with absolute ethanol for 30min, then rinse with deionized water several times until it is clean, and place in an oven. Dry at 60°C for later use;

[0033] 2. Preparation of bioactive glass powder:

[0034] The bioactive glass was prepared by the sol-gel method. The specific...

Embodiment 2

[0046] 1. Preparation of chitosan fiber cloth layer:

[0047] Take the gram weight as 80g / m 2 The chitosan fiber is loosely mixed by hand, and is combed and loosened with a small flat carding machine; 3 pieces of fiber webs are taken, and the grammage of each piece of fiber is 550g / m 2 Lay the web in parallel by hand, so that the fibers are arranged longitudinally; then use a needle punching machine for reinforcement, the frequency of needle punching is 1000 punches / min, and the depth of needle punching is 4mm, and the chitosan fiber cloth is cut into bone damage repair materials. Cut into a square with a side length of 2cm and a thickness of 3mm. The pore size of the fiber cloth is 300-500μm. Ultrasonic cleaning with absolute ethanol for 30min, then rinse with deionized water several times until it is clean, and place it in an oven. Dry at 60°C for later use;

[0048] Step (2) and step (3) are the same as in Example 1.

Embodiment 3

[0050] 1. Preparation of chitosan fiber cloth layer:

[0051] Take the weight as 100g / m 2 The chitosan fiber is manually loosened and mixed, and combed and loosened with a small flat carding machine; 4 fiber webs are taken, and the grammage of each fiber is 550g / m 2 Lay the web in parallel by hand so that the fibers are arranged longitudinally; then use a needle punching machine for reinforcement, the frequency of acupuncture is 1200 punches / min, and the depth of needle punching is 4 mm. Shape, cut into a square with a side length of 2cm and a thickness of 3mm, the pore size of the fiber cloth is 200-300μm, ultrasonic cleaning with absolute ethanol for 30min, and then rinsed with deionized water several times until it is clean, placed in an oven, 60 Dry at ℃ for later use;

[0052] Step (2) and step (3) are the same as in Example 1.

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Abstract

The invention relates to a preparation technology of an artificial bone repairing material in the fields of an inorganic nonmetallic material and a biomedical material, and particularly relates to a three-dimensional ordered porous bracket material of chitosan fiber / bioactive glass and a preparation method of the three-dimensional ordered porous bracket material. The porous bracket material is composite bioactive glass at the surface of a chitosan fiber; the aperture is 80-500mu m; adhesive proliferation of a human bone cell is facilitated; and rapid forming of a new bone is facilitated. The preparation method comprises the steps of: coating mixed pulp of the bioactive glass on chitosan fiber cloth which is reinforced by puncture by a sol-gel dip-coating method, drying and repeating for 0-3 times. The three-dimensional ordered porous bracket material has the advantages of good biological activity, biocompatibility, biological degradability and the like, has obvious mechanical strength and good mechanical property, and can meet the demands of providing stress support to a bone repair part.

Description

technical field [0001] The invention relates to the preparation technology of artificial bone repair materials in the fields of inorganic non-metallic materials and biomedical materials, in particular to a chitosan fiber / bioactive glass three-dimensional ordered porous scaffold material and a preparation method thereof. Background technique [0002] Surgical resection of osteomyelitis, bone tumors, bone cysts and large bone defects caused by trauma is one of the most common and difficult problems in clinical medicine at home and abroad. new ideas and methods. At present, bone tissue engineering research has gradually formed a relatively complete theory and technical route on seed cells, cell carrier scaffold materials and tissue construction. In the research of bone tissue engineering, bio-scaffold material occupies a very important position. It not only acts as a support to maintain the shape of the original tissue, but also acts as a template to provide cells with a host,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/20A61L27/56A61L27/54
Inventor 柯勤飞郭亚平阳俊刘怡卓
Owner SHANGHAI NORMAL UNIVERSITY
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