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Synthesis method for bulk drug of calamine powder

A technology of calamine powder and synthesis method, which is applied in the direction of pharmaceutical formulations, chemical instruments and methods, zinc compounds, etc., can solve problems affecting drug quality and threatening drug safety, and achieve full response, high bioavailability, and short reaction time Effect

Active Publication Date: 2013-10-09
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the nature of the associated minerals, these heavy metal impurities are almost impossible to remove in the traditional calamine powder processing technology, which will affect the quality of medicines and threaten the safety of medicines

Method used

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  • Synthesis method for bulk drug of calamine powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Weigh 265g of industrial-grade zinc sulfate heptahydrate and 160g of ammonium bicarbonate, add purified water and stir to fully dissolve, filter to get the filtrate; mix the two filtrates, add 1.0ml of ammonia water dropwise, heat up to 37°C~ Between 45°C, keep warm at 40°C, and stir the reaction evenly. Use pH test paper to detect the reaction solution, and stop the reaction when the pH value of the reaction solution reaches between 6 and 7, and the reaction time is 40 minutes. The feed liquid is filtered, dehydrated, and the solid is washed with purified water until the filtrate does not contain sulfate ions (with 0.1% acidic BaCl 2 The solution was tested for no white turbidity), dried in the air for use, and weighed 100 g of solid powder, with a yield of 95.7%.

[0027] (2) Remove iron from iron red by magnet, grind finely, sieve with 1250 mesh, weigh 0.3g of powder, put into reaction bottle together with (1) medium basic zinc carbonate powder, add 320mL of pur...

Embodiment 2

[0029] (1) Weigh 265g of industrial-grade zinc sulfate heptahydrate and 160g of ammonium bicarbonate, add purified water and stir to fully dissolve, filter to get the filtrate; mix the two filtrates, add 1.5ml of ammonia water dropwise, and heat up to 37°C~ Between 45°C, keep warm at 42°C, and stir the reaction. Use pH test paper to detect the reaction solution, and stop the reaction when the pH value of the reaction solution reaches between 6.5 and 7, and the reaction time is 35 minutes. The feed liquid is filtered, dehydrated, and the solid is washed with purified water until the filtrate does not contain sulfate ions (with 0.1% acidic BaCl 2 The solution was tested for no white turbidity), dried in the air for use, and weighed 101.06 g of solid powder, with a yield of 96.8%.

[0030] (2) Iron red iron is removed by a magnet, ground finely, screened with a 1250-mesh sieve, weighed 0.3g of the powder, put it into the reaction bottle together with (1) medium-basic zinc carbon...

Embodiment 3

[0032] (1) Weigh 265Kg of industrial-grade zinc sulfate heptahydrate and 160Kg of ammonium bicarbonate, add purified water and stir to fully dissolve, filter to get the filtrate; mix the two filtrates, add 2.0L of ammonia water, heat up to 37°C~45°C Between ℃, keep warm at 38 ℃, stir the reaction. Use pH test paper to detect the reaction solution, and stop the reaction when the pH value of the reaction solution reaches between 6.5 and 7, and the reaction time is 30 minutes. The feed liquid is centrifuged, dehydrated, and the solid is washed with purified water until the filtrate does not contain sulfate ion (with the acidic BaCl of 0.1% by weight percentage 2 The solution was checked for no white turbidity), dried in the air for use, and the solid powder mass was weighed 98.8kg, and the yield was 94.6%.

[0033] (2) Iron red iron is removed by a 0.18T weak magnetic field magnetic separator, crushed with an ultra-fine airflow vortex pulverizer, and sieved through a 1250-mesh s...

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Abstract

The invention discloses a synthesis method for a bulk drug of calamine powder. The synthesis method comprises the following steps of: a, respectively adding water into industrial-grade zinc vitriol and ammonium bicarbonate, dissolving and the filtering, then, mixing the two solutions, dropwise adding a small amount of ammonium hydroxide, sufficiently stirring the mixed solution to react, stopping reacting when the reaction solution is neutral, centrifuging, and washing a solid by using a purified water until the filtrate contains no sulfate ions to obtain basic zinc carbonate powder; b, after carrying out magnetic separation on iron oxide red powder to remove iron, crushing and sieving, putting the iron oxide red powder and the basic zinc carbonate powder into a reaction tank, adding the purified water and a dispersing agent, sufficiently stirring the mixture, washing the mixed powder until the filtrate contains no phosphate anions, carrying out centrifugal dewatering to obtain mixed powder, drying, and further crushing and sieving to obtain calamine powder, wherein the basic zinc carbonate powder is obtained in the former step. The calamine powder obtained by using the method has the advantages of high effective ingredient content, few impurities, high distribution uniformity of the basic zinc carbonate powder and iron oxide and fineness; all indexes of the calamine powder are higher than the pharmacopoeia standards.

Description

technical field [0001] The invention relates to the field of raw material drug synthesis technology, in particular to a method for producing calamine powder, especially a method for synthesizing high-purity and high-quality medicinal calamine powder. Background technique [0002] Calamine powder is a basic zinc carbonate mixture containing a small amount of iron oxide. It has antiseptic and astringent effects. It is widely used in dermatology as a moderate antiseptic, astringent and protective agent to treat skin inflammation or surface wounds. According to traditional Chinese medicine, calamine The stone can detoxify, improve eyesight and relieve cloudiness, reduce dampness, relieve itching and sores. For conjunctival swelling and pain, red and rotten eyes, pannus pterygium, unrestrained ulcer, dripping pus, eczema, skin itching, generally use 5% to 10% water suspension (lotion), and also use oil anointed. Studies have shown that this product has a certain inhibitory effe...

Claims

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Application Information

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IPC IPC(8): A61K33/30C01G9/00
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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