Method for preparing biodegradable magnesium alloy surface modification fluoridated hydroxyapatite coating

Abstract

The invention relates to a method for preparing a biodegradable magnesium alloy surface-modified fluorinated hydroxyapatite coating, specifically: pretreatment of the magnesium alloy substrate, the conversion liquid used is composed of sodium dihydrogen phosphate dihydrate and nitric acid tetrahydrate Calcium-phosphorous coating was obtained by immersing the pretreated substrate sample in the conversion solution for 5h~100h; Alkali fluoride conversion solution is made of sodium hydroxide and sodium fluoride, the concentration of sodium hydroxide is controlled at 3~4g / L, the concentration of sodium fluoride is 4~5g / L, without heat treatment, calcium fluoride phosphorus coating is obtained layer; the calcium fluoride phosphorus coating was heat-treated at 300-350°C for 2-5 hours to prepare fluorinated hydroxyapatite; performance test: the morphology of the FHA coating prepared by combining the heat treatment process was elongated and flake-like and Arranged from the center to the surrounding, the electrochemical test shows that the FHA coating improves the self-corrosion potential of the substrate, and the immersion corrosion test shows that the actual protective effect of the FHA coating on the magnesium alloy substrate is better than that of the FA coating.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable magnesium alloy surface modified fluorinated hydroxyapatite coating. Background technique [0002] In recent years, biomedical degradable materials have attracted widespread attention, and they are mainly used for diagnosing, treating, repairing or replacing damaged tissues and organs of living organisms, and improving their functions. Compared with other kinds of biological materials, the development of biomedical metal materials appears to be relatively slow in recent years. However, metal materials have the advantages of high strength, fatigue resistance, and good forming ability. These properties make medical metal materials still occupy an important position in clinical practice, and metal materials can be better reflected in bones and teeth that need to bear large loads. The advantages. Applied devices are mainly fracture internal fixation plates, screws, artificial joints and roo...

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Problems solved by technology

[0005] However, as a new type of bone tissue engineering material, magnesium alloy material has two important scientific problems in its research and application, which greatly restricts its further development in the medical field, making it impossible to realize the commercialization of medical magnesium alloy.

These two problems are: (1) Material science: too fast degradation of magnesium and its alloys in vivo will also lead to too fast decay of mechanical properties of degradable magnesium alloy bone tissue devices in vivo, which will affect the effect of repair and reconstruction; There is still a lack of research on the material design of degradable magnesium alloys for human applications; the change in the mechanical strength of magnesium alloys during the degradation process in the body is also an important content that needs further research; in view of the special mechanical properties of magnesium alloys compared with other metals, for the use of degradable magnesium alloys The preparation process and technology of degradable magnesium alloy devices also need to be developed and evaluated