Method for bonding carboxymethyl chitosan bioactive molecules on surface of magnesium alloy

A technology of carboxymethyl chitosan and bioactive molecules, which is applied in the field of surface modification of magnesium alloys, can solve problems such as easy corrosion, achieve simple operation, improve corrosion resistance and biocompatibility, and overcome the effects of easy falling off

Inactive Publication Date: 2014-03-26
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the active nature of magnesium alloys, it is easy to corrode in aqueous

Method used

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  • Method for bonding carboxymethyl chitosan bioactive molecules on surface of magnesium alloy
  • Method for bonding carboxymethyl chitosan bioactive molecules on surface of magnesium alloy
  • Method for bonding carboxymethyl chitosan bioactive molecules on surface of magnesium alloy

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0028] Example 1

[0029] 1. Cathodic liquid plasma treatment

[0030] Use 2500 mesh and 5000 mesh sandpaper to polish the surface of the magnesium alloy until it is bright, remove the oxide layer on the surface, and then ultrasonically clean the surface with acetone 3 times for 5 minutes each, and then polish the surface of the graphite rod smoothly with 5000 mesh sandpaper. Wash 3 times, 5 minutes each time. Use 0.08mol / L NaCl water-ethanol solution as electrolyte, where the volume ratio of deionized water to absolute ethanol is 1:4, clean magnesium alloy as cathode and clean graphite rod as anode, immerse in electrolysis In the liquid, the DC pulse power supply is used, the discharge voltage is adjusted to 400V, the frequency is 100Hz, the duty cycle is 30%, and the cathode-anode spacing is 4cm. The magnesium alloy is subjected to cathodic liquid plasma deposition. The discharge treatment time is 15 minutes. MgO corrosion-resistant coating is formed on the surface of magnesium...

Example Embodiment

[0037] Example 2

[0038] In step 1 of the cathodic liquid phase plasma treatment in this embodiment, a 0.05mol / L NaCl water-ethanol solution is used as the electrolyte, where the volume ratio of deionized water to absolute ethanol is 1:2, and a DC pulse power supply is used. The discharge voltage is 350V, the frequency is 150Hz, the duty cycle is 25%, and the anode-cathode spacing is 5cm. The magnesium alloy is subjected to cathodic liquid plasma deposition, and the discharge treatment time is 20 minutes. MgO corrosion-resistant coating is formed on the surface of the magnesium alloy . The other steps are the same as in Example 1 to obtain a magnesium alloy with carboxymethyl chitosan bioactive molecules bonded on the surface.

Example Embodiment

[0039] Example 3

[0040] In the cathodic liquid phase plasma treatment step 1 of this embodiment, a 0.12mol / L NaCl water-ethanol solution is used as the electrolyte, where the volume ratio of deionized water to absolute ethanol is 1:5, and a DC pulse power supply is used. The discharge voltage is 500V, the frequency is 130Hz, the duty cycle is 35%, the cathode-anode distance is 3cm, the magnesium alloy is subjected to cathodic liquid plasma deposition, the discharge treatment time is 10 minutes, and the MgO corrosion-resistant coating is formed on the magnesium alloy surface . The other steps are the same as in Example 1 to obtain a magnesium alloy with carboxymethyl chitosan bioactive molecules bonded on the surface.

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Abstract

The invention discloses a method for bonding carboxymethyl chitosan bioactive molecules on the surface of magnesium alloy. According to the method, a dopamine polymer film is formed on the surface of the magnesium alloy subjected to cathode liquid phase plasma processing by means of spontaneous deposition and polymerization of dopamine hydrochloride in alkaline ethanol solutions, and the carboxymethyl chitosan can be bonded on the surface of the magnesium alloy through the amidation between amidogen and carboxyl in a dopamine polymer medium layer. According to the method, the operation is easy, a carboxymethyl chitosan film layer formed on the surface of the magnesium alloy is flat and smooth and not prone to falling off, corrosion resistance and biocompatibility of the magnesium alloy can be effectively improved, the defects that the surface of a coating obtained through the cathode liquid phase plasma processing is rough, multiporous and crackled are overcome, the defect that a polymer coating formed through a physical modification method is prone to falling off is also overcome, and therefore the method lays the foundation for magnesium alloy to be used as biomedical materials.

Description

technical field [0001] The invention belongs to the technical field of magnesium alloy surface modification, and specifically relates to a method of bonding carboxymethyl chitosan on the surface of a magnesium alloy by using a polydopamine film as a medium layer and combining cathodic liquid phase plasma technology and chemical modification technology Methods for Bioactive Molecules. Background technique [0002] As a new type of biomedical material, magnesium alloy has attracted extensive attention due to its excellent mechanical properties, good biocompatibility and unique biodegradability. Magnesium alloy has low density, high specific strength and specific stiffness, elastic modulus and compressive strength close to natural bone, and magnesium is an essential element for human metabolism, which can promote the growth of bone tissue. Therefore, magnesium alloys have great application potential in orthopedics and cardiovascular system repair. However, the corrosion resis...

Claims

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Application Information

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IPC IPC(8): B05D7/14B05D7/24C25D9/12
Inventor 陈亚芍易金红黄林林
Owner SHAANXI NORMAL UNIV
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