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Drug for treating chicken Eimeria tenella

An Eimeria coccidiosis and tender technology, applied in the field of traditional Chinese veterinary medicine, can solve problems such as failure of coccidiosis control, reduced feed rate, slow weight gain, etc., so as to improve the body's disease resistance, promote body growth, Less toxic and side effects

Inactive Publication Date: 2014-04-16
QINGDAO HUAREN TECH INCUBATOR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complexity and particularity of the development of coccidia in the host body, the coccidia continue to develop drug resistance. As early as the 1960s, drug-resistant strains appeared. All coccidiostats are resistant and show some cross-resistance
Due to the long-term use of chemical drugs, the drug resistance of coccidia is produced, and the emergence of drug-resistant strains makes the prevention and control of coccidiosis fail. Usually, coccidiosis outbreaks can still occur under the condition of medication, bloody stools and death occur, but coccidia The hazards of subclinical infection of the disease are more serious, causing slowed weight gain and reduced feed return rate

Method used

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  • Drug for treating chicken Eimeria tenella
  • Drug for treating chicken Eimeria tenella
  • Drug for treating chicken Eimeria tenella

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0041] The present invention also provides a preparation method for the above-mentioned feed, which includes:

[0042] The first step is to prepare traditional Chinese medicine powder feed additive according to the above method;

[0043] In the second step, all the raw materials of the above-mentioned feeds are combined in proportion, put into a compound mixer and stirred for 150 minutes, taken out, put into a ring mode grinder, and pulverized into powder, then taken out and put into a dryer, and controlled The dryness of the dried material is 70% to 80%, and the baking time is 50 to 70 minutes. Take it out and let it cool, put it in a compound mixer and stir for 190 minutes, take it out and put it in a ring mode puffing machine for puffing, and control the temperature The temperature is between 70°C and 80°C, the expansion time is 1 to 2 hours, and the dryness of the expanded material is controlled at 80% to 90%. After taking it out, it is transferred to a ring mode hard pell...

Embodiment 1

[0072] Example 1 Decoction 1

[0073] Put 40g Changshan, 75g rhubarb, 25g Caulis Spatholobus, 30g Rhizoma Polygonatum, 55g blue cloth, 20g madder, 60g cork, 35g uncaria, 25g Agrimony, 35g heterophylla, 30g dogwood, 35g Brucea javanica, 35g velvet grass, golden 25g of lotus flower, 35g of dandelion, 50g of ginseng leaf, 15g of dried lacquer, 25g of mountain silver flower, 30g of toosendan, 25g of purslane, 40g of acanthopanax, 25g of saponins, 30g of oridonium, 25g of Kochia scoparia , 35g rehmannia glutinosa, 25g Guan Phellodendron cortex and 20g licorice, add 8kg of water, soak for 1 hour and then decoct. After heating to boiling with strong fire, maintain simmering fire for 2 hours, then filter, combine the two filtrates, and concentrate the medicinal solution to decoction 1 with a crude drug concentration of 1 g / ml.

Embodiment 2

[0074] Embodiment 2 toxicological experiment

[0075] Acute Toxicity Test

[0076] Select 20 Kunming mice, half and half female, body weight (20+2) g, provided by the Qingdao Experimental Animal Center, and the decoction prepared in Example 1 was fed to the mice. LD 50, so the maximum tolerated dose was measured, with an administration volume of 2.0ml / 10g body weight, fed twice / d with an interval of 6h, observed for 7d after administration, and recorded animal death and side effects symptoms. At the end of the experiment, the All animals were processed, dissected, and the lesions of the main organs and tissues were observed with the naked eye. After 2 times of gavage of 140g crude drug / kg, the animals moved, and no abnormalities were found in eating and drinking. The animals died after 7 days of observation, and no major organs and tissues were found in the autopsy with the naked eye. obvious exception.

[0077] long-term toxicity test

[0078] Select 40 male SD rats with ...

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Abstract

The invention provides a drug for treating chicken Eimeria tenella. The drug comprises crude medicines such as antifebrile dichroa, rheum officinale, caulis spatholobi, sealwort, aleppo avens, madder, golden cypress, uncaria, agrimonia pilosa, radix pseudostellariae, dogwood, brucea javanica, savatier monochasma herbs, trollflower, elephantopus scaber, ginseng leaves, resina toxicodendri, lonicerae flos, szechwan chinaberry fruits, purslane, cortex acanthopanacis, spina gleditsiae, rabdosia rubescens, fructus kochiae, prepared rehmannia roots, cortex phellodendri amurense and liquorice. The drug is not prone to development of drug resistance and extremely small in toxic and side effects and has the advantages of capabilities of promoting the organism growth, enhancing the immunity, improving the disease resistance of organisms and the like, the purpose of coccidiosis prevention can be achieved, the problem of drug residues which are harmful to human bodies and hinder export of broiler chickens can be solved, in addition, the immunity of the organisms can be enhanced, the growth and the development of the chickens can be promoted, and the productivity of the chickens can be improved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese veterinary medicine, in particular to a medicine for treating chicken Eimeria tenella. Background technique [0002] In a broad sense, coccidia should include protozoa of Eimeriaceae, Cryptosporiaceae, Toxoplasma gondii and Sarcosporium sarcoides, and the traditionally called coccidia refer specifically to protozoa of Eimeriaceae . Eimeria tenella is a protozoan disease caused by a variety of coccidia of the genus Eimeria parasitizing in the intestinal epithelial cells of chickens. The disease is a serious disease caused by coccidia parasitizing the host's intestinal epithelial cells or hepatic bile duct epithelium. in the cells of the host, and disintegrate the host cells, destroying the integrity of the host cell tissue, causing inflammation, hemorrhage, dysfunction, and at the same time the disintegrated cells produce toxins, causing the host's own poisoning; in addition, because ...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A23K1/16A23K1/18A61P33/02A61P37/04
Inventor 孙霞
Owner QINGDAO HUAREN TECH INCUBATOR
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