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Zwitterionic polymer modified polyurethane material and preparation method thereof

A technology of polyurethane materials and zwitterions, which is applied in the field of zwitterionic polymer modified polyurethane materials and preparations, can solve the problems of formation, restenosis and thrombus, and achieve the effects of anti-platelet adsorption, low cytotoxicity, and simple modification methods

Inactive Publication Date: 2014-04-16
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of small-caliber artificial blood vessels, although there are various research reports on modified polyurethane, there are still shortcomings such as restenosis and thrombosis, so improving the blood compatibility of polyurethane materials is an urgent problem to be solved today.

Method used

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  • Zwitterionic polymer modified polyurethane material and preparation method thereof
  • Zwitterionic polymer modified polyurethane material and preparation method thereof
  • Zwitterionic polymer modified polyurethane material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation method of zwitterionic polymer modified polyurethane material comprises the steps:

[0038] (1) Proportionally dissolve 25mg of sultaine norbornene polymer in 5mL of mixed solvent to make a mixed solution, add 10mg of L-cysteine ​​and 0.2mg of benzophenone to the mixed solution; Under the protection of nitrogen, react under 300 watts of ultraviolet light at 18 cm for 5 minutes to obtain a mixed solution. The reaction mixed solution is precipitated with ether to obtain a zwitterionic polymer containing amino groups. The mixed solvent is hexafluoroisocyanurate with a volume ratio of 1:1. propanol and dichloromethane;

[0039] (2) 25 mg of the product obtained in step (1), 20 mg of toluene diisocyanate, 1 g of polycarbonate polyurethane (relative molecular mass of 250,000), 5 mL of N, N-dimethylformamide, and 5 mg of stannous octoate At 80°C, polymerize for 1 hour to obtain a zwitterionic polymer-modified polyurethane material; the structure of the sulfobe...

Embodiment 2

[0044] The preparation method of zwitterionic polymer modified polyurethane material comprises the steps:

[0045] (1) Dissolve 70mg of sultaine norbornene polymer in 10mL of mixed solvent in proportion to make a mixed solution, add 100mg of L-cysteine ​​to the mixed solution, add 2,4-dihydroxydiphenyl Methanone 10 mg; under the protection of nitrogen, react with light at 30 cm under a 300-watt ultraviolet lamp for 1 hour to obtain a mixed solution, and precipitate the reaction mixed solution through ether to obtain a zwitterionic polymer containing amino groups. The volume ratio of the mixed solvent is 2: 1 of hexafluoroisopropanol and dichloromethane;

[0046] (2) Combine 70mg of the product obtained in step (1), 100mg of 2,4-toluene diisocyanate, 1g of polycarbonate polyurethane (relative molecular mass: 50,000), 5mL of N,N-dimethylformamide, in 20mg of octanoic acid Stannous effect, polymerization reaction at 100°C for 10 hours to obtain zwitterionic polymer modified poly...

Embodiment 3

[0049] The preparation method of zwitterionic polymer modified polyurethane material comprises the steps:

[0050] (1) Proportionally dissolve 140 mg of sultaine norbornene polymer in 10 mL of mixed solvent to make a mixed solution, add 100 mg of L-cysteine ​​and 20 mg of Michler's ketone to the mixed solution; Under 300 watts of ultraviolet light, the light was reacted at 50 centimeters for 2 hours to obtain a mixed solution, and the reaction mixed solution was precipitated with ether to obtain a zwitterionic polymer containing amino groups. The mixed solvent was hexafluoroisopropanol with a volume ratio of 3:1 and Dichloromethane;

[0051] (2) Combine 150mg of the product obtained in step (1), 200mg of 2,6-toluene diisocyanate, 1g of polyester polyurethane (relative molecular mass: 250,000), 10mL of N,N-dimethylformamide, in 20mg of octanoic acid sulfide Tin effect, at 120 ° C, polymerization reaction for 24 hours, to obtain zwitterionic polymer modified polyurethane materi...

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Abstract

The invention discloses a zwitterionic polymer modified polyurethane material and a preparation method thereof. The preparation method comprises the following steps: (1) adding a photoinitiator into sulfobetaine norbornene polymer and L-cysteine to react to obtain an amino-containing zwitterionic polymer; (2) carrying out polymerization on the obtained zwitterionic polymer, isocyanate and polyurethane prepolymer or polyurethane under the action of a tin-containing catalyst to obtain the zwitterionic polymer modified polyurethane material. Experiments prove that the polyurethane material prepared by using the preparation method of the zwitterionic polymer modified polyurethane material has high hydrophilic performance, antiplatelet adsorption and low cytotoxicity and favorable blood compatibility and biocompatibility and is beneficial to endotheliocyte adhesion and proliferation. The preparation method is simple.

Description

technical field [0001] The invention belongs to the technical field of medical polymer materials, and in particular relates to zwitterionic polymer modified polyurethane materials and a preparation method. technical background [0002] Medical materials usually refer to a class of natural or synthetic special functional materials that can directly contact and interact with the human body, and can treat, replace, repair or induce regeneration of cells, tissues and organs. As a biomedical material directly used in the human body, it needs to have many excellent properties, such as: ① Biological functionality: according to the specific application environment and use requirements, it should have biological functionality. For example, tissue engineering biomaterials require adhesion to cells, promotion and Induce cell proliferation and other biological functions; ②Biocompatibility, such as blood compatibility, low cytotoxicity, etc.; ③Chemical stability, for long-term implantati...

Claims

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Application Information

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IPC IPC(8): C08G18/78C08G18/62C08F132/08C08F8/34A61L33/06
CPCA61L27/18A61L27/50A61L27/507A61L31/06A61L31/14C08F8/34C08G18/10C08G18/6287C08G18/62C08F132/08C08L75/04
Inventor 冯亚凯穆萨米尔·卡恩杨静吕娟李茜
Owner TIANJIN UNIV
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