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Preparation method of medical porous metal material capable of replacing weight bearing bone tissue

A technology of porous metal and bone tissue, applied in medical science, prosthesis, etc., can solve the problems of reduced biological safety, insufficient purity of finished products, carbon skeleton residues, etc., to achieve improved mechanical properties, high yield of finished products, and pore distribution uniform effect

Active Publication Date: 2015-04-08
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitations of its preparation method, the purity of the obtained finished product is not enough, and there are carbon skeleton residues, resulting in a decrease in biological safety

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Weigh zinc stearate, tantalum powder with an average particle size less than 43 microns and oxygen content less than 0.1% and hydrogen peroxide and mix evenly, wherein zinc stearate accounts for 11%, hydrogen peroxide accounts for 18%, and tantalum powder accounts for 71%. All are calculated by volume percentage. Pressure molding: Add the above mixed powder into an injection molding machine and press it into a polyurethane foam (pore diameter 0.48-0.89mm, density 0.015 g / cm2) at 87Mpa 3 ~0.035g / cm 3 , the hardness is greater than 50 0 ) in forming. Degreasing treatment: vacuum degree 10 -3 Pa, from room temperature to 400°C at a heating rate of 1.4°C / min and hold for 311 minutes; then at a heating rate of 0.4°C / min from 400°C to 750°C for a holding time of 350 minutes. Vacuum sintering: vacuum degree is 10 -3 Pa, heat up to 1800°C at 13°C / min, hold for 200min, cool with the furnace to 200-300°C, then heat up to 1800°C at 17°C / min, hold for 230min, heat u...

Embodiment 2

[0026] Embodiment 2: Weigh stearic acid and paraffin, tantalum powder with an average particle size less than 43 microns and oxygen content less than 0.1% and hydrogen peroxide and mix evenly, wherein stearic acid accounts for 9%, paraffin accounts for 3%, hydrogen peroxide accounts for 25%, tantalum Powder accounts for 63%, all in volume percentage. Pressure molding: Add the above mixed powder into an injection molding machine and press it into a polyurethane foam (pore diameter 0.48-0.89mm, density 0.015 g / cm2) at 75Mpa 3 ~0.035g / cm 3 , the hardness is greater than 50 0 ) in forming. Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 600°C at a heating rate of 0.3°C / min, and hold for 360min. Vacuum sintering: vacuum degree is 10 -4 Pa, heat up to 1500°C at 10°C / min, hold for 240min, cool with the furnace to 200-300°C, then heat up to 1500°C at 20°C / min, hold for 180min, heat up to 2000-2200°C at 10°C / min, Keep warm for 120min and cool down. Heat tr...

Embodiment 3

[0028] Embodiment 3: Take isoprene rubber, tantalum powder with an average particle size less than 43 microns and an oxygen content of less than 0.1% and ammonium bicarbonate and mix evenly, wherein isoprene rubber accounts for 7%, ammonium bicarbonate accounts for 15%, and tantalum powder accounts for 78% %, all in volume percentage. Pressure molding: Add the above mixed powder into an injection molding machine and press it into a polyurethane foam (pore diameter 0.48-0.89mm, density 0.015 g / cm2) at 96Mpa 3 ~0.035g / cm 3 , the hardness is greater than 50 0 ) in forming. Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 400°C at a heating rate of 2°C / min, and hold for 300min. Vacuum sintering: vacuum degree is 10 -3 Pa, heat up to 1700°C at 20°C / min, hold for 120min, cool with the furnace to 200-300°C, then heat up to 1670°C at 10°C / min, hold for 240min, heat up to 2000-2200°C at 5°C / min, Keep warm for 360min and cool down. Heat treatment: vacuum deg...

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PUM

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Abstract

The invention provides a preparation method of a medical porous metal material capable of replacing weight bearing bone tissue, which comprises the following steps: mixing tantalum powder and ammonium bicarbonate or hydrogen peroxide, and a forming agent (one or more of stearic acid, zine stearate, paraffin and synthetic resin), compression moulding, degreasing, sintering, cooling and heat treating; wherein the compression moulding step is characterized in that a mixture is compacted in organic foams, the pressure is 50-100MPa, the degreasing step is characterized in that heating is gradually carried out at the rate of 0.3 DEG C / min-2 DEG C to the temperature of 400-800 DEG C, argon is protection atmosphere and is insulated for 300-360 minutes; the sintering step is characterized in that the degree of vacuum is 10<-4>Pa-10<-3>Pa, heating is carried out at the rate of 10-20 DEG C / min to the temperature of 1500-1800 DEG C, the insulation is carried out for 120-240 minutes, and then cooling is carried out to 200-300 DEG C, heating is carried out at the rate of 10-20 DEG C / min to 1500-1800 DEG C, insulation is carried out for 180-240 minutes, then heating is carried out at the rate of 5-10 DEG C / minutes to 2000-2200 DEG C, and then insulation is carried out for 120-360 minutes. The medical porous metal material is a medical implantation material which has the advantages of large porosity and good mechanical property, and is suitable for replacing the weight bearing bone tissue.

Description

[0001] The application of the present invention is a divisional application with application number 201110296535.4, application date September 29, 2011, and the title of the invention "a preparation method of a medical porous metal material that replaces load-bearing bone tissue". technical field [0002] The invention relates to a preparation method of a porous medical metal implant material, in particular to a preparation method of a medical porous metal implant material which replaces the bone tissue of a load-bearing part. Background technique [0003] Porous medical metal implant materials have important and special uses in the treatment of bone tissue trauma and femoral tissue necrosis. Common materials of this type include porous metal stainless steel and porous metal titanium. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected and evenly distribut...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/04C22C1/08C22C27/02
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD