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Preparation method of magnetic carbon nano-tube surface molecular imprinting polymer for biological sample pretreatment

A technology of magnetic carbon nanotubes and molecular imprinting on the surface, which can be applied to chemical instruments and methods, and other chemical processes, and can solve problems affecting human health, etc.

Inactive Publication Date: 2014-07-09
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, since these drugs are widely used clinically, they remain in food and waters with the circulation of environmental substances, directly or indirectly affecting the health of the human body. The natural selection of microorganisms leads to the evolution of drug-resistant and pathogenic microorganisms, which poses a potential threat to the long-term survival and development of human beings. Therefore, it is urgent to establish a method for the detection of trace quinolone residues in complex samples of food and the environment

Method used

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  • Preparation method of magnetic carbon nano-tube surface molecular imprinting polymer for biological sample pretreatment
  • Preparation method of magnetic carbon nano-tube surface molecular imprinting polymer for biological sample pretreatment
  • Preparation method of magnetic carbon nano-tube surface molecular imprinting polymer for biological sample pretreatment

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Experimental program
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Effect test

Embodiment 1

[0031] Add 0.5 g of multi-walled carbon nanotubes to 100 ml of concentrated HNO with a volume ratio of 1:3 3 - Concentrated H 2 SO 4 The mixed solution was sonicated for 2 h, and then refluxed at 80 °C for 12 h under magnetic stirring. Then, filter under reduced pressure, wash repeatedly with distilled water until neutral, dry in vacuum at 65°C overnight, and set aside;

[0032] Add 0.4g of the above-prepared carboxylated carbon nanotubes, 2.4g of ferric chloride, 3.4g of sodium acetate and 3.4g of sodium acrylate into a mixed solvent consisting of 22.5ml of ethylene glycol and 22.5ml of diethylene glycol, and sonicate for 1h Get a black mixed solution, transfer it to a polytetrafluoroethylene reaction kettle, seal it, and place it in a muffle furnace to react for 10 hours. After the reaction, cool to room temperature, wash it with methanol and water several times, and dry it in vacuum at 65°C. to constant weight, spare;

[0033] Dissolve 1 g of the above-prepared magnetic...

Embodiment 2

[0038] Add 0.5 g of multi-walled carbon nanotubes to 100 ml of concentrated HNO with a volume ratio of 1:3 3 - Concentrated H 2 SO 4 The mixed solution was sonicated for 2 h, and then refluxed at 80 °C for 12 h under magnetic stirring. Then, filter under reduced pressure, wash repeatedly with distilled water until neutral, dry in vacuum at 65°C overnight, and set aside;

[0039] Add 0.4g of the above-prepared carboxylated carbon nanotubes, 2.4g of ferric chloride, 3.4g of sodium acetate and 3.4g of sodium acrylate into a mixed solvent consisting of 22.5ml of ethylene glycol and 22.5ml of diethylene glycol, and sonicate for 1h Get a black mixed solution, transfer it to a polytetrafluoroethylene reaction kettle, seal it, and place it in a muffle furnace to react for 10 hours. After the reaction, cool to room temperature, wash it with methanol and water several times, and dry it in vacuum at 65°C. to constant weight, spare;

[0040] Dissolve 1 g of the above-prepared magnetic...

Embodiment 3

[0045] Add 0.5 g of multi-walled carbon nanotubes to 100 ml of concentrated HNO with a volume ratio of 1:3 3 - Concentrated H 2 SO 4 The mixed solution was sonicated for 2 h, and then refluxed at 80 °C for 12 h under magnetic stirring. Then, filter under reduced pressure, wash repeatedly with distilled water until neutral, dry in vacuum at 65°C overnight, and set aside;

[0046] Add 0.4g of the above-prepared carboxylated carbon nanotubes, 2.4g of ferric chloride, 3.4g of sodium acetate and 3.4g of sodium acrylate into a mixed solvent consisting of 22.5ml of ethylene glycol and 22.5ml of diethylene glycol, and sonicate for 1h Get a black mixed solution, transfer it to a polytetrafluoroethylene reaction kettle, seal it, and place it in a muffle furnace to react for 10 hours. After the reaction, cool to room temperature, wash it with methanol and water several times, and dry it in vacuum at 65°C. to constant weight, spare;

[0047] Dissolve 1 g of the above-prepared magnetic...

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Abstract

The present invention relates to a preparation method of a magnetic carbon nano-tube surface molecular imprinting material having an imprinting carrier with a functional monomer effect and adopting an alternative template technology to avoid template leakage. The preparation method mainly comprises the following steps: preparing magnetic carbon nano-tubes, preparing vinyl-modified magnetic carbon nano-tubes, carrying out a surface molecular imprinting polymerization reaction, and eluting the template molecules. According to the present invention, the synthesis method is simple and is easy to perform, the prepared magnetic carbon nano-tube surface molecular imprinting material has characteristics of uniform active center, strong recognition specificity, excellent magnetic property, high mechanical strength, high absorption capacity, rapid binding kinetics and the like; and the preparation method can be used for ideal absorption agents or coating materials, and chromatogram separation fillers of various types of solid-phase extraction technologies, can further be used for preparation of molecular imprinting sensors and chips, and provides important significance for special quinolone drug recognition and high sensitivity detection research.

Description

technical field [0001] The invention belongs to the technical field of molecular imprinting on the surface of magnetic carbon nanotubes, and particularly relates to a method for preparing imprinted polymers through surface molecular imprinting technology using vinylated magnetic carbon nanotubes as functional monomers and carriers, using quinolone drugs as substitute templates method, the composite material prepared by the method has a specific recognition effect on quinolones. Background technique [0002] Molecular imprinting technology is a highly selective separation technology. Its basic idea comes from people's understanding of antibody-antigen specific recognition in the field of immunology. The use of polymer materials with molecular recognition capabilities - molecularly imprinted polymers (MIP), to isolate, screen and purify compounds. Compared with conventional separation or analysis media, molecularly imprinted polymers have the outstanding advantages of high se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F220/06C08F226/06C08J9/26B01J20/26B01J20/30B01J20/285
Inventor 何华肖得力彭军何小梅袁丹华李卉戴昊皮埃尔·他目
Owner CHINA PHARM UNIV
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