Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of preparation method of antioxidant-coated polymer nanovesicles

An antioxidant and nano-vesicle technology, applied in the field of skin beauty and health care chemicals, can solve the problems of no way to eliminate free radicals, no skin, harmful to human body, etc., achieve high-efficiency anti-ultraviolet performance, delay skin aging, and stable structure Effect

Inactive Publication Date: 2016-04-06
TONGJI UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing sunscreen products, both organic and inorganic, have major defects and are often harmful to the human body; inorganic products including titanium dioxide, zinc oxide or some other heavy metal oxides have strong photocatalytic capabilities, and these active ingredients will be released in the human body. The skin triggers a catalytic reaction that produces free radicals that can cause damage to human skin
In addition, these products only play a role in eliminating ultraviolet rays, and have no effect on skin health. They have no way to eliminate free radicals; and free radicals are an important factor causing skin aging

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of antioxidant-coated polymer nanovesicles
  • A kind of preparation method of antioxidant-coated polymer nanovesicles
  • A kind of preparation method of antioxidant-coated polymer nanovesicles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 0.5g macroinitiator PEO 43 -Br, 0.08g of catalyst ligand PMDETA, 0.8g of monomer DMA and 2ml of anhydrous methanol were added to the round bottom flask, macroinitiator PEO 43 The molar ratio of -Br, catalyst ligand PMDETA and monomer DMA is 1:1:20; Add 0.08g catalyst CuBr under the condition of anhydrous and oxygen-free; 43 The number of moles of -Br is the same. Atom transfer radical polymerization (ATRP) was carried out under the protection of argon or nitrogen, the reaction temperature was 25°C, and the reaction time was 8 hours. After the reaction, 3.9 g of monomeric styrene was dissolved in 10 ml of p-xylene, and added to the flask after deoxygenation. The reaction temperature was 60° C., and the reaction time was 50 hours. The prepared polymer is rotary evaporated, dissolved, passed through a neutral alumina column, precipitated, filtered, and vacuum-dried to obtain the amphiphilic block copolymer PEO 43 -b-PDMA 20 -b-PS 110 ; Wherein the mol ratio of styrene...

Embodiment 2

[0031] 0.5g macroinitiator PEO 43 -Br, 0.24g catalyst ligand PMDETA, 2.4g monomer DMA and 2ml anhydrous methanol were added to the round bottom flask, macroinitiator PEO 43 The molar ratio of -Br, catalyst ligand PMDETA and monomer DMA is 1:3:60; Add 0.08g catalyst CuBr under the condition of anhydrous and oxygen-free; 43 The number of moles of -Br is the same. Atom transfer radical polymerization (ATRP) was carried out under the protection of argon or nitrogen, the reaction temperature was 40°C, and the reaction time was 13 hours. After the reaction, 7.8 g of monomeric styrene was dissolved in 10 ml of p-xylene, and added to the flask after deoxygenation. The reaction temperature was 80° C., and the reaction time was 60 hours. The prepared polymer is rotary evaporated, dissolved, passed through a neutral alumina column, precipitated, filtered, and vacuum-dried to obtain the amphiphilic block copolymer PEO 43 -b-PDMA 60 -b-PS 220 ; Wherein the mol ratio of styrene and bro...

Embodiment 3

[0034] 0.5g macroinitiator PEO 43 -Br, 0.4g catalyst ligand PMDETA, 3.2g monomer DMA and 3ml anhydrous methanol were added to the round bottom flask, macroinitiator PEO 43 The molar ratio of -Br, catalyst ligand PMDETA and monomer DMA is 1:4:80; Add 0.08g catalyst CuBr under the condition of anhydrous and oxygen-free; 43 The number of moles of -Br is the same. Atom transfer radical polymerization (ATRP) was carried out under the protection of argon or nitrogen, the reaction temperature was 50°C, and the reaction time was 18 hours. After the reaction, 11.7 g of monomeric styrene was dissolved in 15 ml of p-xylene, and added to the flask after deoxygenation. The reaction temperature was 130° C., and the reaction time was 12 hours. The prepared polymer is rotary evaporated, dissolved, passed through a neutral alumina column, precipitated, filtered, and vacuum-dried to obtain the amphiphilic block copolymer PEO 43 -b-PDMA 80 -b-PS 340 ; Wherein the mol ratio of styrene and br...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
polydispersity indexaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for preparing an anti-oxidant coated polymer nano-vesicle. The method comprises the following steps: mixing bromo-polyoxyethylene, pentamethyldiethylenetriamine, dimethylaminoethyl methacrylate and a solvent in water-free and oxygen-free condition, adding cuprous bromide or cuprous chloride, and performing atom transfer radical polymerization in argon or nitrogen protection at 20-80 DEG C for 6-20 hours; dissolving styrene in anhydrous paraxylene, deoxidizing, and adding into the atom transfer radical polymerization to react at 40-130 DEG C for 12-72 hours; evaporating and dissolving the prepared polymer, passing the prepared through a neutral alumina column, precipitating, filtering and drying in vacuum to obtain an amphiphilic block copolymer PEO-b-PDMA-b-PS; dissolving the PEO-b-PDMA-b-PS and an antioxidant in THF (tetrahydrofuran), dripping deionized water or methanol which is 3-10 times of the THF at a speed of 1-60d / min under intense stirring; dialyzing in deionized water, and drying to obtain the product. The product obtained by the method can play a good health-care effect on skin, and can be used for delaying skin aging.

Description

technical field [0001] The invention belongs to the technical field of skin beauty and health care chemicals, and relates to a preparation method of a skin care product that can effectively delay skin aging, in particular to a preparation method of polymer nanovesicles coated with antioxidants. Background technique [0002] With the progress of the industrialization era, various toxic gases are discharged into the atmosphere, and the resulting environmental problems have become increasingly prominent; among them, the destruction of the ozone layer is a very prominent problem. Due to the destruction of the ozone layer, a large amount of ultraviolet rays pass through the atmosphere and directly irradiate the human skin. Excessive ultraviolet radiation not only causes great damage to people's skin, but also greatly increases the chance of suffering from skin cancer. Therefore, there are an endless stream of sunscreen products on the market, and these products mainly absorb or ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K45/00A61K8/14A61K8/86A61K8/81A61K8/67A61K8/64A61K8/36A61K47/32A61K47/34C08F293/00C08F212/08C08F220/34A61P17/18A61Q17/04A61Q19/08A23L33/10A23L33/15A23L33/18A23P10/30A23L33/00A23P10/00
Inventor 杜建忠孙辉
Owner TONGJI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com