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A kind of nano carboxymethyl chitosan sodium fluoride anti-caries coating film and its preparation method and application

A technology of carboxymethyl chitosan sodium fluoride and carboxymethyl chitosan is applied in the field of stomatology to achieve the effects of inhibiting the adhesion and growth of bacteria, slow release of strong drugs, and inhibiting the occurrence and development of early caries

Inactive Publication Date: 2016-06-15
HOSPITAL ATTACHED TO QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there are few reports on the application of chitosan and its derivatives and self-etching adhesives to fluoride coatings.

Method used

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  • A kind of nano carboxymethyl chitosan sodium fluoride anti-caries coating film and its preparation method and application
  • A kind of nano carboxymethyl chitosan sodium fluoride anti-caries coating film and its preparation method and application
  • A kind of nano carboxymethyl chitosan sodium fluoride anti-caries coating film and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation method of nano carboxymethyl chitosan sodium fluoride anti-caries coating film of the present invention comprises the following steps:

[0039] 1. Preparation of carboxymethyl chitosan sodium fluoride nanoparticles

[0040] The selected carboxymethyl chitosan is a water-soluble chitosan derivative, which belongs to the polysaccharide biopolymer, and has the characteristics of slow drug release, antibacterial and biocompatibility, and 0.5g of carboxymethyl chitosan The polysaccharide was dissolved in deionized water, prepared into 20ml of 25mg / ml carboxymethyl chitosan solution, and filtered through a microporous filter with a pore size of 0.45 μm to remove insoluble impurities in the solution. Weigh 0.135 g of sodium fluoride solid with an analytical balance, add it into the carboxymethyl chitosan solution, stir at room temperature for 30 min, and prepare the carboxymethyl chitosan sodium fluoride solution. Prepare a 10mg / ml sodium tripolyphosphate solu...

Embodiment 2

[0051] Example 2, Nano carboxymethyl chitosan sodium fluoride anti-caries coating film fluoride ion release experiment

[0052] The purpose of the experiment: To compare the common fluoride coating, test its advantages in drug sustained release, and at the same time screen out the anti-caries coating of nano carboxymethyl chitosan sodium fluoride with high drug sustained release performance.

[0053] experimental method:

[0054] (1) Drawing of fluoride ion standard curve

[0055] Use a graduated cylinder to accurately measure 0.01ml, 0.05ml, 0.10ml, 0.50ml, 1.00ml, 1.50ml, 2.00ml, 4.00ml of fluorine standard solution into a 50ml volumetric flask, add release medium to make up 10ml, add TISABⅡ solution to the mark, Shake well, pour into a plastic beaker, put in a stirrer, stir with a magnetic stirrer for 2 minutes, and let it stand for 1 minute. After measuring the temperature, measure the potential of each solution with the fluoride ion selective electrode method from low to...

Embodiment 3

[0067] Example 3, Nano carboxymethyl chitosan sodium fluoride anti-caries coating inhibits enamel demineralization

[0068] The purpose of the experiment: In simulating the occurrence process of oral caries, the famous Freestone PH cycle model was used to characterize the ability of different fluoride coatings to inhibit the demineralization of enamel.

[0069] experimental method:

[0070] Collect 40 fresh bovine incisors with no caries, no cracks, and no enamel hypoplasia, remove the soft tissue on the root surface, separate the crown root, ultrasonically clean the crown, remove plaque and pigment on the enamel surface, and cut the crown with a hard tissue cutter Make 40 enamel pieces of size 5mm×5mm×2mm, ultrasonically clean them with deionized water for 10 minutes, blow dry, and use a polishing machine and silicon carbide sandpaper (800 # 、1000 # , 2000 # ) smooth the lip enamel surface under running water. At the same time, about 150 μm of the enamel surface layer was...

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Abstract

The invention provides a nanometer carboxymethyl chitosan sodium fluoride anti-caries coating as well as a preparation method and an application thereof. The nanometer carboxymethyl chitosan sodium fluoride anti-caries coating is generated by using carboxymethyl chitosan nanoparticles with the characteristics of medicine controlled release functions, antibacterial activity, biocompatibility and the like, self-acid etching resin adhesive with the photocuring property and corresponding fluorides. According to the preparation method, firstly carboxymethyl chitosan is prepared into nanoparticles, and a sodium alginate solution is added in a nanoparticles forming process so as to promote formation of the nanoparticles with centralized particle size distribution. The nanometer carboxymethyl chitosan sodium fluoride anti-caries coating is capable of effectively releasing main anti-caries active medicine fluorine ions and meanwhile assisting the fluorine ions to inhibit enamel demineralization, adhesion and growth of bacteria and occurrence and development of early caries and has a remarkable prevention effect on caries in oral diseases.

Description

technical field [0001] The invention belongs to the field of stomatology, and in particular relates to a caries-preventing coating of nanometer carboxymethyl chitosan sodium fluoride and its preparation method and application. Background technique [0002] Caries is a common oral disease that seriously affects human health. With the improvement of people's living standards, oral medical workers are required to take preventive measures against dental caries. Local fluoride anti-caries is recognized as one of the effective anti-caries measures, and fluoride coating is more and more concerned because it is easy to operate, safe, effective, easy to accept, and suitable for people of all ages. The fluoride coating is widely used in clinical caries prevention because of its simple operation, high safety performance and obvious caries prevention effect. Studies have shown that fluoride coatings have obvious advantages over other types of anti-caries preparations in drug sustained...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/097A61K6/02A61K6/898
Inventor 许晓燕徐全臣张岱尊
Owner HOSPITAL ATTACHED TO QINGDAO UNIV