Molecularly imprinted polymer on the surface of carbon nanotubes and its preparation method and application

A surface molecular imprinting, carbon nanotube technology, applied in the direction of material electrochemical variables, can solve problems such as unfavorable business and social development, a large number of pollutants, environmental hazards, etc., to improve electrical conductivity and current response speed, time-consuming, Sensitive high effect

Active Publication Date: 2017-02-15
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] Similar to the problems existing in the prior art for surface graft modification of multi-walled carbon nanotubes, the disadvantage of this preparation method is that step (1) directly grafts alkenyl groups on the surface of multi-walled carbon nanotubes, requiring Large amounts of organic solvents such as concentrated HNO are used 3 , concentrated H 2 SO 4 , SOCl 2 , DMF, pyridine, etc., not only the operation process is dangerous, but also produces a large amount of pollutants, which seriously endangers the environment and is not conducive to the development of enterprises and society

Method used

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  • Molecularly imprinted polymer on the surface of carbon nanotubes and its preparation method and application
  • Molecularly imprinted polymer on the surface of carbon nanotubes and its preparation method and application
  • Molecularly imprinted polymer on the surface of carbon nanotubes and its preparation method and application

Examples

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Effect test

Embodiment 1

[0085] Example 1 Preparation of molecularly imprinted polymer on the surface of carbon nanotubes

[0086] 1. Preparation of molecularly imprinted polymers on the surface of carbon nanotubes

[0087] The preparation process of molecularly imprinted polymer on carbon nanotube surface is as follows figure 1 shown, including the following steps:

[0088] (1) Purification of carboxylated multi-walled carbon nanotubes

[0089] In order to remove a small amount of amorphous carbon and metal impurities in carboxylated multi-walled carbon nanotubes (CNTs), CNTs-COOH was purified. The purification method is as follows:

[0090] In a 100 mL round bottom flask, place 40.0 mL of H 2 O, 9.28mL HNO 3 Mix well, then add 2.0 g CNTs-COOH, and reflux at 85 °C for 48 h. After filtration, the CNTs-COOH was washed with deionized water until neutral, and dried under vacuum at 60 °C for 12 h for use.

[0091] (2) Synthesis of silica-coated multi-walled carbon nanotubes

[0092] Weigh 250.0 mg ...

Embodiment 2

[0112] Example 2 Preparation of electrochemical sensor

[0113] 1. Preparation of electrochemical sensors

[0114] (1) The bare glassy carbon electrode (GCE, 3 mm in diameter) was sequentially used with 0.3 μm and 0.05 μm Al 2 O 3 Powder suspension polishing treatment, and then use absolute ethanol, ddH 2 o Ultrasonic (53KHz) cleaning, 10min each time, finally placed at room temperature to dry, for use;

[0115] (2) Take 20.0 mg γ-MAPS / CNTs@SiO 2 -MIPs were added to 1mL of 0.5% chitosan solution, sonicated at 53KHz for 60min, and the two were mixed evenly to obtain a mixed solution; then 5.0 μL of the mixed solution was applied and dropped on the surface of the bare glassy carbon electrode treated in step (1). After drying at room temperature for 6 hours, the imprinted electrode (γ-MAPS / CNTs@SiO) was obtained. 2 -MIPs / GCE);

[0116](3) Take the imprinted electrode of step (2) as the working electrode, take the saturated calomel electrode as the reference electrode, take ...

Embodiment 3

[0147] Example 3 Detection of actual samples by electrochemical sensors

[0148] In order to investigate the detection feasibility of the electrochemical sensor of the present invention, the actual sample rutin tablet was detected.

[0149]First, use a mortar to grind commercially available rutin tablets, and then use ethanol to ultrasonically dissolve them completely to obtain a rutin tablet dissolving solution; take an appropriate amount of the upper rutin tablet dissolving solution and use PBS buffer (pH 4.5) Dilute to 5mL. Then, the imprinted electrode was immersed in the above diluent, stirred and adsorbed for 7 min, and DPV detection was carried out. Each sample was tested 5 times in parallel, and the average value was taken.

[0150] Table 2

[0151]

[0152] It can be seen from Table 2 that the detection value of the imprinted electrode is basically consistent with the marked value, the recovery rate is 99.5%-100.5%, and the relative standard deviation is 1.9%-2.8...

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Abstract

The invention discloses a carbon nanotube surface molecularly imprinted polymer as well as a preparation method and application thereof. The preparation method comprises the following steps: taking carboxylated multi-walled carbon nanotubes, synthesizing silicon dioxide-coated multi-walled carbon nanotubes by a sol-gel method; modifying the silicon dioxide-coated multi-walled carbon nanotubes by using a silane coupling agent to obtain alkenylated multi-walled carbon nanotubes; mixing the alkenylated multi-walled carbon nanotubes, Rutin and acrylamide under the protection of inert gas, and performing radical polymerization under the existence of an initiator and a cross-linking agent to prepare the carbon nanotube surface molecularly imprinted polymer. An electrochemical sensor manufactured from the carbon nanotube surface molecularly imprinted polymer has the characteristics of good conductivity, high selectivity, fast response, high sensitivity and the like to the Rutin and can quickly and effectively detect Rutin content of a sample.

Description

technical field [0001] The invention belongs to the technical field of molecularly imprinted polymers, in particular to a molecularly imprinted polymer on the surface of carbon nanotubes and a preparation method and application thereof. Background technique [0002] Rutin, also known as vitamin P, as a drug, rutin can reduce the permeability and fragility of capillaries, maintain and restore the normal elasticity of capillaries. Adjuvant treatment of epistaxis, etc. It is necessary to establish a fast, accurate, sensitive and convenient new method for rutin drug detection for quality control and clinical analysis. [0003] At present, the main methods for the detection of rutin include high performance liquid chromatography, capillary electrophoresis, fluorescence spectroscopy and electrochemical sensor methods. However, high performance liquid chromatography, capillary electrophoresis and other methods have problems such as complicated operation, expensive instruments, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F292/00C08F220/56C08F220/06C08F226/06C08J9/26G01N27/30
Inventor 李蕾曾延波汤传贵李倩张剑曹红刘海清尹争志
Owner JIAXING UNIV
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