Developing degradable polymer stent and preparation method thereof

Abstract

The invention provides a developing degradable polymer stent and a preparation method thereof. A plasma vapor deposition method is adopted to deposit a degradable developing material on the surface of a bracket; the prepared developing coating is not transmitted under X ray, so that the stent can be clearly seen under X ray, and therefore, some interferences of a metal developing material on MRI (magnetic resonance imaging) and CT (computed tomography) images are avoided, and problems that side effects are easily produced as biocompatibility of the metal developing material is poor, and the metal developing material cannot be degraded and left in a blood vessel cavity after the stent is degraded are solved; according to the method, activation hydrophilic treatment is carried out on the surface of the polymer bracket, so as to improve affinity between the polymer base body and the developing coating and effectively solve the coating dropping problem; besides, a protective coating which is slow in degradation rate is coated on the surface of the developing coating, so that too quick degradation of the developing coating is prevented, and therefore, follow-up can be still carried out in the later stage of implanting.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to a fully degradable polymer bracket that can be developed and a preparation method thereof. Background technique [0002] Traditionally used stents for the treatment of vascular stenosis are all made of metal materials, which can be clearly seen under X-rays, but because the materials cannot be degraded and absorbed by the human body, they will permanently stay in the human body after implantation, like a metal "vest" "It also restricts the normal contraction and pulsation of blood vessels, and in severe cases, it will cause late thrombosis of the stent and cause the death of the patient. Furthermore, the existence of metal implants will affect the subsequent MRI or CT images of blood vessels and interfere with the doctor's judgment. [0003] In view of the existence of such problems, degradable stents that can be degraded and absorbed by the human body have emerged as th...

AI Technical Summary

Problems solved by technology

However, this method also has its disadvantages: the bonding strength with the main body of the stent is weak, and it is easy to fall off during the subsequent stent crimping and opening, resulting in poor developing effect; secondly, the dipping / spraying of the stent takes a long time to dry. Remove the solvent; moreover, the developer layer coated on the outer layer of the stent will disappear prematurely with the degradation of the material, which will cause inconvenience to the late follow-up of the stent

There is also a method of grafting iodine atoms to develop the stent, but the grafting rate of iodine atoms is very low, making the development efficiency very low

[0006] In view of the problems of poor biocompatibility and possible side effects of indwelling metal developers in the prior art; and the complex preparation of the developing coating, the coating is easy to fall off, cracks and other instability problems during the preparation and implantation process, further research is needed Discovery-stable, biocompatible X-ray-opaque stents

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