Sperm optimal selection device based on microtubule passages and optimal selection method

A sperm and channel technology, applied in the field of sperm selection, can solve the problems of sperm DNA peroxidation damage, sperm quality is difficult to control, and sperm quality decline, so as to avoid sperm quality decline, sperm quality is easy to control, and the screening effect is good Effect
CN104099237AInactive Publication Date: 2014-10-15ZHEJIANG CELLPRO BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG CELLPRO BIOTECH
Publication Date
2014-10-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a sperm optimal selection device based on microtubule passages. The sperm optimal selection device comprises a sample tank and a sperm collection tank, obstruction blocks in one to three stages are arranged between the sample tank and the sperm collection tank, microtubule passages are overspreaded on the obstruction blocks in a direction from the sample tank to the sperm collection tank, the inner diameters of the microtubule passages are 10-200 micrometer, high-quality and high-activity sperm preferentially reach the sperm collection tank by using the initiative attracting of a sperm nutrient solution to sperms, the blocking of the obstruction blocks, and microporous competitive passing, and under an effect of activity competition, the sperms in the sperm collection tank are highly energetic. According to the method provided by the invention, the selection is simple, the sperm recovering ratio is high, sperm quality reduction is avoided at the same time, and the selecting effect is good. Therefore, sperm optimal selection device based on microtubule passages has the advantages of simple selection, good selecting effect, high recovering rate, and easiness in sperm quality control.
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Description

technical field

[0001] The invention relates to sperm selection, in particular to a sperm selection device and method based on microtubules. Background technique

[0002] Sperm motility is one of the key factors for conception. Semen with a high sperm motility rate has a relatively high number of motility sperm, so the probability of conception is also high. The currently widely used sperm selection technologies include upstream technology, density gradient centrifugation technology and other optimization technologies. The upstream technology is designed by using the principle of sperm’s own vitality to swim upwards. During the upstream process, sperm can break away from some endogenous antisperm substances in the seminal plasma, such as anti-sperm antibodies, various cells, etc., and make the sperm The time of in vitro activity can be extended, but the recovery rate of high-quality sperm is relatively low in the upstream technology. The recovery rate of high-quality sperm...

Claims

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