Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof

A technology of chlorine dioxide and effervescent tablets, which is applied in the direction of antibacterial drugs, antifungal agents, and pharmaceutical formulations, etc. It can solve problems such as low conversion rate, fragile tablets turn into powder, and slow rate, so as to accelerate dissolution Process, bactericidal effect advantage, effect of bactericidal effect enhancement

Inactive Publication Date: 2014-11-12
龚佳郎
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN200810054571.8 proposes monobasic chlorine dioxide effervescent tablet and its preparation method. The conversion rate of chlorine dioxide is not high after the effervescent tablet involved in the system is dissolved in water, and the tablet is f

Method used

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  • Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof
  • Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof
  • Chlorine dioxide effervescent tablet for killing barbier bacteria and fungi and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Tablets weighing 4 grams were prepared using the following formulation.

[0044] Raw material name (kg)

Raw material ratio

Sodium chlorite (80% content)

10

Sodium dichloroisocyanurate

5

magnesium sulfate

3

Sodium chloride

32

Aluminum trichloride

4.5

PVP / VA64

3

citric acid

39

sodium bicarbonate

3

Cetyl chloramine

0.5

[0045] First put the above-mentioned raw material components into the dryer to dry, raise the temperature to 90°C, and discharge the intermediate when the moisture content of the intermediate is controlled below 1%. Put it in a plastic lined bag bucket or an airtight plastic bucket for later use.

[0046] First add 10 kg of sodium chlorite to the mixer, then add 3 kg of sodium bicarbonate, 0.5 kg of cetylchloramine, 3 kg of magnesium sulfate, and 32 kg of sodium chloride and mix thoroughly for 10 to 20 minutes. Minutes later, add 5 kg of...

Embodiment 2

[0051] Tablets weighing 1 gram were prepared using the following formulation.

[0052] Raw material name (kg)

Raw material ratio

Sodium chlorite (80% content)

20

Sodium dichloroisocyanurate

10

magnesium sulfate

2

Sodium chloride

19

Aluminum trichloride

3

L-HPC

2.5

citric acid

39

sodium bicarbonate

2

Cetyl chloramine

0.5

sodium persulfate

2

[0053] First put the above-mentioned raw material components into the desiccator to dry, raise the temperature to 90°C, and discharge the intermediate when the moisture content of the intermediate is controlled below 1%, and then crush and sieve through a pulverizer and a vibrating sieve, and put them into moisture-proof containers. Store in a plastic lined bag or an airtight plastic bucket.

[0054] First add 20 kilograms of sodium chlorite to the mixer, then add 2 kilograms of sodium bicarbonate, 0.5 kilogram...

Embodiment 3

[0059] Tablets weighing 4 grams were prepared with the following formulation;

[0060] Raw material name (kg)

Raw material ratio

Sodium chlorite (80% content)

6

Sodium dichloroisocyanurate

3

magnesium sulfate

3

Sodium chloride

32

Aluminum trichloride

4

Polyvinylpyrrolidone

2.5

citric acid

40

sodium bicarbonate

5

Cetyl chloramine

0.5

sodium persulfate

3

[0061] The formulation raw materials are made according to the preparation methods described in Implementation 1 and Implementation 2. After obtaining the combined raw materials for tablets, use a 20mm punch to compress tablets with a pressure of 60KN in a tablet press, and press them into tablets with a weight of 4 grams. Use a pure aluminum foil bag Or high-barrier anti-corrosion plastic bags for packaging.

[0062] 4 gram tablet is dropped into 4 liters of water, after 20 minutes, the concentra...

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Abstract

The invention discloses a chlorine dioxide effervescent tablet for killing barbier bacteria and fungi. The chlorine dioxide effervescent tablet comprises the following components in percentage by weight: 3-15% of chlorite, 5-30% of drying agent, 3-25% of activating agent, 2-15% of solid acid, 4-15% of bonding agent, 0.5-3% of surfactant, 0.5-5% of effervescing agent, 1-12% of demolding agent and 1-25% of catalysts. The chlorine dioxide effervescent tablet has the technical effects that the tablet is gradually dissolved from outside to inside when being dissolved in water; relevant components can be dissolved and reacted at the same time; a carbon dioxide gas is generated in the dissolution process, so that the dissolution speed of the table is accelerated on one hand, and on the other hand a partial effervescence effect is achieved; due to the adopted cationic surfactant, the sterilization effect of the generated chlorine dioxide is further improved; active catalysts, including aluminum trichloride and sodium persulfate, are further introduced under the neutral condition, so that a generated chlorine dioxide sterilization solution is neutral, and the irritation and corrosion to a sterilized object are alleviated.

Description

technical field [0001] The invention relates to an effervescent tablet capable of producing chlorine dioxide when dissolved in water and a preparation method thereof. Background technique [0002] Athlete's foot (tinea pedis) is a foot skin disease caused by pathogenic fungi and is contagious. Tinea pedis is widespread throughout the world, more generally in tropical and subtropical regions. In my country, the incidence rate of tinea pedis is very high, reaching more than 70%. Tinea pedis is also a chronic infection, and fungus grows and breeds in the stratum corneum of the skin, and the patient needs long-term medication to be cured, and the recurrence rate is also high. Some domestic medical institutions all adopt Chinese medicine and bactericidal cream to treat, mainly based on the general control to the beriberi patient's state of an illness, reach the method for a kind of maintenance treatment, can not solve the purpose that beriberi patient does not relapse after cur...

Claims

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Application Information

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IPC IPC(8): A61K33/20A61K9/46A61P17/00A61P31/10A61P31/04
Inventor 龚佳郎
Owner 龚佳郎
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