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Antibacterial medical dressing film carrying nano-silver and cellulose nanocrystalline hybrid materials and preparation method thereof

A hybrid material and cellulose technology, applied in the field of new multifunctional fully biodegradable composite membrane and its preparation, can solve the problems of difficulty in blocking bacterial re-infection, lack of effective combination of nano silver and cellulose nanocrystals, etc. Biocompatibility and cytocompatibility, increase synergistic enhancement effect, increase reproduction speed effect

Inactive Publication Date: 2014-11-19
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nano-silver is directly added to the polymer matrix, resulting in the lack of effective combination of nano-silver and cellulose nanocrystals, and the solution-cast composite film material is difficult to block the re-infection of bacteria

Method used

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  • Antibacterial medical dressing film carrying nano-silver and cellulose nanocrystalline hybrid materials and preparation method thereof
  • Antibacterial medical dressing film carrying nano-silver and cellulose nanocrystalline hybrid materials and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]Add the hemp fiber into the formic acid-hydrochloric acid solution and react at 48°C for 12 hours. The solid-to-liquid ratio of microcrystalline cellulose and the mixed acid aqueous solution is 1:60 g / mL. mol / L) volume ratio is 6:1, after the reaction is finished, the reaction product is washed with deionized water until neutral, and the aldylated cellulose nanocrystals can be obtained; then the aldylated cellulose nanocrystals are added to In a 0.03 mol / L silver nitrate solution, react at 85°C for 20 min, in which the solid-to-liquid ratio of the aldylated cellulose nanocrystals to the silver nitrate solution is 1:100 g / mL. Dilute the reaction product with water, centrifuge several times to remove the inorganic ions, and then vacuum-dry the dispersion to obtain the nanosilver-cellulose nanocrystalline hybrid material;

[0037] Add nano-silver-cellulose nanocrystalline hybrid material and polyhydroxybutyrate valerate (PHBV) into chloroform, raise the temperature to 70°C,...

Embodiment 2

[0041] Add microcrystalline cellulose into formic acid-hydrochloric acid solution and react at 70°C for 2 h. The solid-to-liquid ratio of hemp fiber to mixed acid aqueous solution is 1:50 g / mL. Formic acid (5 mol / L) and hydrochloric acid ( 7 mol / L) with a volume ratio of 8:1. After the reaction, the reaction product was washed with deionized water until neutral to obtain aldylated cellulose nanocrystals; then the aldylated cellulose nanocrystals Add 0.3 mol / L silver nitrate solution, react at 80°C for 35 min, wherein the solid-liquid ratio of cellulose nanocrystals and silver ammonia solution is 1:220 g / mL, after the reaction is finished, use Dilute the reaction product with ionized water, centrifuge several times to remove the inorganic ions, and then vacuum-dry the dispersion to obtain the nanosilver-cellulose nanocrystalline hybrid material;

[0042] Add the nanosilver-cellulose nanocrystalline hybrid material to the N,N-dimethylformamide solution of polyhydroxybutyrate val...

Embodiment 3

[0046] The hemp fiber was added into the formic acid-hydrochloric acid solution and reacted at 40°C for 8 h. The solid-liquid ratio of the bamboo fiber to the mixed acid aqueous solution was 1:60 g / mL, and the formic acid (6 mol / L) and hydrochloric acid (4 mol / L) volume ratio is 8:1, after the reaction is finished, the reaction product is washed with deionized water to neutrality, and aldehyde-based cellulose nanocrystals can be obtained; then add 0.08 mol / L silver-ammonia solution, reacted at 78 °C for 51 min, and the solid-liquid ratio of cellulose nanocrystals and silver-ammonia solution was 1:150 g / mL. Dilute the reaction product, centrifuge several times to remove inorganic ions, and then vacuum-dry the dispersion to obtain nanosilver-cellulose nanocrystalline hybrid material;

[0047] Add the nano-silver-cellulose nanocrystalline hybrid material to the ethyl acetate solution of polycaprolactone (PCL), raise the temperature to 48°C, and stir thoroughly to obtain a transp...

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Abstract

The invention relates to an antibacterial medical dressing film carrying nano-silver and cellulose nanocrystalline hybrid materials and a preparation method thereof. The film comprises biodegradable polymers and the nano-silver and cellulose nanocrystalline hybrid materials with the mass ratio of 3-99 : 1. The preparation method comprises the steps that (1) cellulose raw materials are added to a mixed acid water solution of formic acid and hydrochloric acid, aldehyde group cellulose nanocrystalline is obtained through reaction, the aldehyde group cellulose nanocrystalline is then added to silver salt solutions with the content of 0.01-3 mol / L, and the nano-silver and cellulose nanocrystalline hybrid materials are obtained through reaction; (2) after the hybrid materials and the biodegradable polymers are added to organic solvents, transparent uniform electrostatic spinning solutions are obtained through reaction; (3) electrostatic spinning is carried out on the electrostatic spinning solutions to obtain the antibacterial medical dressing film. The preparation method is simple in preparation technology and suitable for industrial large-scale production, the multifunctional composite film is biodegradable and good in mechanical and thermal property, breathability, antibacterial effect, biocompatibility and cytocompatibility.

Description

[0001] technical field [0002] The invention belongs to the field of novel multifunctional fully biodegradable composite film and its preparation, and in particular relates to an antibacterial medical dressing film loaded with nano silver-cellulose nano crystal hybrid material and a preparation method thereof. [0003] Background technique [0004] As global warming and increased population mobility due to urbanization and globalization make various forms of bacterial infection more serious, it is becoming increasingly important to inhibit the growth and reproduction of bacteria. Clinically, in order to control the bacteria on the wound and prevent infection, many medical sanitary materials are added with antibiotics or various antibacterial materials. Although antibiotics take effect quickly, antibiotics and antibacterial materials have limited antibacterial effects, and there are many kinds of bacteria, so the effect of dressings containing antibiotics or antibacterial m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4382D04H1/728A61L15/28A61L15/26A61L15/62A61L15/44
Inventor 余厚咏张冬子李志刚陈国印杨兴远陈旺平
Owner ZHEJIANG SCI-TECH UNIV
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