Application of carbon dot as anti-tumor medicine carrier
An anti-tumor drug, carbon dot technology, applied in the field of nanomedicine, can solve the problems of protein non-specific adsorption, poor drug loading stability, increased drug side effects, etc., and achieves high drug loading rate, good water solubility, and high quantum yield. Effect
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Embodiment 1
[0037] The preparation of thiolated doxorubicin comprises the following steps:
[0038] (1) Dissolve doxorubicin in a solution (pH=8.0) of dimethyl sulfoxide (DMSO) and phosphate buffer (PBS), and add Traut in the amount of 3 times the substance of doxorubicin ’ s reagent;
[0039] (2) React at room temperature for 1 hour to obtain thiolated doxorubicin.
Embodiment 2
[0041] Preparation of AEEA carbon dots, see figure 1 , including the following steps:
[0042] (1) Into the glycerol, feed nitrogen for 5 minutes to remove the oxygen in the glycerol;
[0043] (2) Add 3-[2-(2-aminoethylamino)ethylamino]propyltrimethoxysilane (AEEA) to glycerol to make its volume fraction 9.1% (5-30%), in a closed state Stir for more than 5 minutes to form a carbon dot precursor solution;
[0044] (3) React in a microwave reactor at 160°C for 15 minutes;
[0045] (4) Centrifuge to remove the precipitate generated, and leave the supernatant;
[0046] (5) Use a dialysis bag with a molecular weight of 1000 to dialyze the supernatant in ultrapure water for more than 48 hours (change the water every 6 hours) to obtain a pure carbon dot solution.
Embodiment 3
[0048] The preparation of aminated carbon dots is similar to that of Example 2, except that in step (3) the microwave reactor was reacted at 180°C for 5 minutes, and the 3-[2-(2-aminoethylamino)ethylamino]propane The volume fraction of trimethoxysilane (AEEA) is 5%.
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