Porous spherical calcium phosphate filling material and preparing method thereof

Abstract

A preparing method of a porous calcium phosphate filling material sequentially comprises the following technical steps: 1, uniformly mixing 5-15 parts by mass of calcium phosphate powder or 10-50 parts by volume of calcium phosphate slurry, 10-50 parts by volume of a sodium alginate water solution, 1-10 parts by volume of an adhesive and 1-20 parts by volume of deionized water, then adding 1-5 parts by volume of hydrogen peroxide or 1-50 parts by mass of a solid pore forming agent, and carrying out uniform mixing to obtain mixed slurry; 2, dripping the mixed slurry obtained in step 1 to a soluble calcium salt solution with 1-10% mass concentration to form a complex gel microsphere, and then curing, washing and drying the complex gel microsphere; 3, presintering the complex gel microsphere obtained in step 2 at 500-800 DEG C for 1-5 hours, then sintering at 900-1200 DEG C, and cooling to a room temperature after finishing sintering. The calcium phosphate filling material prepared according to the method is adjustable in grain size and controllable in crystalline grain size, and accordingly, is convenient to implant in clinic.

Description

technical field [0001] The invention belongs to the technical field of biological material preparation, in particular to a porous spherical calcium phosphate bone filling material and a preparation method thereof. Background technique [0002] With the aging population, bone defects caused by osteoporosis, congenital bone disease or infection, bone tumor and accidental injury are increasing day by day, which has become a major problem affecting human life and health, and the demand for bone filling materials is also increasing day by day. [0003] Calcium phosphate bioceramics is a bone filling material widely used clinically at present, but the existing granular calcium phosphate bone filling materials are usually formed by mold method, crushing method or granulation method. Using the mold method to prepare calcium phosphate bone filling materials with different regular shapes requires the design of molds with different regular shapes, and the processing technology is compl...

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Problems solved by technology

Using the mold method to prepare calcium phosphate bone filling materials with different regular shapes requires the design of molds with different regular shapes, and the processing technology is complicated. At the same time, the bone filling materials prepared by the mold method generally have low porosity, which is not conducive to the degradation of the material when implanted in the body. and bone ingrowth, slower rate of bone repair

The crushing method mainly produces granular bone filling materials by crushing block materials, so the obtained calcium phosphate particles have irregular shapes and poor particle uniformity. In clinical practice, bone filling materials with more uniform particle sizes are needed to achieve good results. bone repair effect

The granulation method is mainly to pass the powder material through a granulation machine to obtain a granular bone filling material. Although the shape of the granular bone filling material prepared by the granulation method is relatively regular, and the particle size can be controlled, the internal structure of the obtained particles is dense. Or the porosity is low, there is no porous through-through structure, and the bone repair ability is poor

In addition, the grain size of the calcium phosphate ceramics prepared in the prior art is mostly micron-scale, and the grain size is too large and uncontrollable. However, the research results show (Materials Science and Engineering R 2010; 70:225-242), Calcium phosphate ceramics with nanostructured grains have higher biological activity than calcium phosphate ceramics with micronized grains

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