High-elasticity strong-hydroscopicity chitosan sponge allowing normal-temperature drying and preparation method thereof

A technology of room temperature drying and chitosan, applied in the field of biomedical materials, can solve problems such as being unfavorable to energy saving and environmental protection, endangering human health, easy to residual toxicity, etc., and achieve the effects of soft texture, short drying time and good mechanical strength

Inactive Publication Date: 2015-04-29
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation method using formaldehyde as a cross-linking agent has a lot of pollution in the preparation process, and the product is prone to residual toxicity, which is harmful to human health; as disclosed in the patent CN1431021A, a drug-containing chitosan-collagen sponge for gynecological diseases is used after freeze-drying. Washing with distilled water and vacuum drying again is time-consuming and energy-consuming, which is not conducive to energy saving and environmental protection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Chitosan hydrochloric acid solution with a mass fraction of 2.45-6.15% and a polyvinyl alcohol aqueous solution with a mass fraction of 2.45-36.9% are mixed 1:6 (volume ratio), and sulfuric acid with a mass fraction of 20-50% is added at 70°C and 600r / min. , stir well, add a certain amount of AMPS, PEG-1000 with a mass fraction of 5-20%, stir until a homogeneous phase, add dropwise a sodium dodecylsulfonate solution with a mass fraction of 0.5-1%, and foam for 0.5-1h , drop glutaraldehyde with a mass fraction of 0.1-0.5%, cross-link for 1-2 hours, add a certain amount of glycerin and mix evenly, pour it into a mold, dry it at room temperature, wash the dried product with alkali, water, NaHSO 3 After soaking in the solution, dry at room temperature to obtain a chitosan sponge. Air permeability of chitosan sponge obtained: 2166.788~4449.823cm 3 / m 2 ·24h·0.1MPa, air permeability coefficient: 1.057×10 -9 ~9.141×10 -9 cm 2 / s, tensile strength: 3.734~4.377MPa, elongati...

Embodiment 2

[0032] Chitosan acetic acid solution with a mass fraction of 2.45-6.15% is mixed with a polyvinyl alcohol aqueous solution with a mass fraction of 2.45-36.9% 1:6 (volume ratio), and a mass fraction of 20-50% is added at 60°C and 450r / min Sulfuric acid, stir well, add dropwise NaHCO with a mass fraction of 0.5-1% 3 Solution, foam for 0.5-1h, dropwise add glutaraldehyde with a mass fraction of 0.1-0.5%, cross-link for 1-2h, add a certain amount of AMPS, PEG-1500 with a mass fraction of 5-20%, stir a certain amount of glycerin until Homogeneous phase, pour it into the grinding tool, dry at room temperature, wash the dried product with alkali, water, NaHSO 3 After soaking in the solution, dry at room temperature to obtain a chitosan sponge. Air permeability of chitosan sponge obtained: 3888.913~5434.826cm 3 / m 2 .24h.0.1MPa, air permeability coefficient: 5.884×10 -9 ~1.023×10 -8 cm 2 / s, tensile strength: 3.453~3.987MPa, elongation at break: 129.34~194.93%, water absorption:...

Embodiment 3

[0034] Chitosan lactic acid solution with a mass fraction of 2.45-6.15% is mixed with a polyvinyl alcohol aqueous solution with a mass fraction of 2.45-36.9% 1:6 (volume ratio), and a certain amount of AMPS is added under the conditions of 50°C and 300r / min, and the mass fraction is 5 ~20% PEG-800, stir until homogeneous phase, dropwise add glutaraldehyde with a mass fraction of 0.1~0.5%, crosslink for 1~2h, add dropwise aliphatic alcohol polyoxyethylene ether sulfuric acid with a mass fraction of 0.5~1% Sodium (AES) solution, foaming for 0.5-1h, adding sulfuric acid with a mass fraction of 20-50%, fully stirring, adding a certain amount of glycerin and mixing evenly, pouring into a mold, drying at room temperature, washing the dried product with alkali, Washing, NaHSO 3 After soaking in the solution, dry at room temperature to obtain a chitosan sponge. Air permeability of chitosan sponge obtained: 4237.183~5899.863cm 3 / m 2 ·24h·0.1MPa, air permeability coefficient: 9.90×1...

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Abstract

The invention relates to high-elasticity strong-hydroscopicity chitosan sponge allowing normal-temperature drying and a preparation method thereof. Through glutaraldehyde crosslinking foaming curing of chitosan and polyvinyl alcohol, sulfuric acid plastification, hydroscopicity improvement by 2-acrylamido-2-methylpropanesulfonic acid (AMPS) and glycerin, and polyethylene glycol (PEG) softening, the high-elasticity strong-hydroscopicity chitosan sponge is prepared. The raw materials comprise chitosan, polyvinyl alcohol, sulfuric acid, PEG, AMPS, glutaraldehyde, a foaming agent, glycerin and water. Compared with the existing sponge, the high-elasticity strong-hydroscopicity chitosan sponge has the advantages of good mechanical strength, permeability, fast liquid-absorption rate, ultra-strong liquid-absorption multiplying power, softness after liquid absorption, good elasticity, normal temperature drying, energy saving, good biocompatibility, simple processes, low cost and environmental friendliness (biodegradability), and can be used as biomedical materials for wound healing, sterilization and bleeding stopping.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a highly elastic and strong water-absorbing chitosan sponge which can be dried at normal temperature and a preparation method thereof. Background technique [0002] As a natural alkaline polysaccharide, chitosan has good biocompatibility. It is a non-toxic, non-immunogenic, degradable ideal medical material, and has a wide range of uses in medicine and other fields. The sponge made of chitosan has chitosan air permeability, moisture permeability, prevents the loss of water and body fluids, antibacterial and anti-inflammatory, has affinity and adhesion with the wound surface, soft, good biocompatibility and degradability, promotes The characteristics of granulation and epithelial tissue regeneration, no scar and no deformation can replace absorbent cotton and absorbent gauze, and do not need to be replaced frequently. Does not contain fiber filaments (heads), and will not affe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L29/04C08L5/08C08L71/08C08K13/02C08K3/30C08K5/42C08K5/053C08K5/07C08J9/08C08J9/04
Inventor 赛明泽郭瑞丁德润钟士亮唐阳马文涛
Owner SHANGHAI UNIV OF ENG SCI
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