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Adhesive and preparation method thereof

An adhesive and equipment technology, which is applied in the field of α-cyanoacrylate-based adhesives and their preparation, can solve the problems of reduced bonding strength, limited viscosity range, complicated processes, etc. Bonding time, the effect of a single product component

Inactive Publication Date: 2015-06-17
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] ①Long process cycle: thickener polymethyl methacrylate (PMMA) monomer molecular weight is small (relative molecular weight is 84), its polymer structure is relatively tight, and the α-cyanoacrylate monomer molecule in the solvent enters the polymer Methyl methacrylate (PMMA) is more difficult inside
[0009] ② After the medical adhesive product is used on the wound, the polymerization degradation is slow and the flexibility is poor: polymethyl methacrylate (PMMA) is a non-degradable polymer, and the polymer formed by it has high hardness, and the product is relatively soft and has a certain Poor patient tolerance when applied to motile tissues
[0010] ③ There is a certain safety risk: the molecular weight of polymethyl methacrylate (PMMA) monomer is small, and α-cyanoacrylate monomer with comparable molecular weight is required to dissolve well, and α-cyanoacrylate monomer with small molecular weight Lower biosafety than bulk α-cyanoacrylate monomers due to shorter side chains
[0014] ①The process is complex and the production cycle is long: although the process time is shortened compared to the process time of adding polymethyl methacrylate (PMMA) as a thickener, it takes about 1-1.5 months for one cycle, but it still takes a long time De-aging, dissolution, etc., because α-cyanoacrylate monomer is very sensitive to the environment, when trace anions such as trace moisture in the air exist, it will trigger polymerization, and the dissolution process is very slow, and repolymerization may be triggered during the dissolution process , the entire production process has very strict requirements on the environment and equipment, and it is difficult to control re-polymerization
[0015] ②The medical adhesive first polymerizes and ages α-cyanoacrylate monomer, and then dissolves it. There are a large amount of aged and inactivated α-cyanoacrylate in the product, which will prolong the bonding time of the adhesive and greatly reduce its Bond strength
The amount of addition is also directly related to the viscosity of the composition. If too much is added, the main component will decrease, which will affect the polymerization time and even make it difficult to cure. Therefore, the viscosity range adjusted by this method is limited to a certain extent.
Moreover, the third component added after curing and adhesive action may be precipitated, and the impact on the human body and the environment remains to be studied

Method used

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  • Adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Add 1mL of ethyl α-cyanoacrylate (the purity is 99.9% as determined by gas chromatography normalization method) to each of ten 2mL ampoules, replace the air inside with high-purity argon, and seal it.

[0051] The above 10 ampoule bottles were labeled as 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 in sequence, and bottle No. 1 was used as a blank control sample without ultraviolet crosslinking. Put bottles 2, 3, 4, 5, 6, 7, 8, 9, and 10 into the heating table in turn, set the temperature at 60°C, adjust the height of the UV lamp shelf to 30cm from the sample, and irradiate with a 1000W UV lamp. According to, the time is respectively 10min, 15min, 20min, 25min, 30min, 35min, 40min, 45min, 50min, finally by the rotational viscometer (model is BROOKFIELD VISCOMETER, DV-Ⅱ+Pro, the viscosity value in each embodiment below all uses Measured by this instrument) to test its viscosity. Viscosity test method is: under anhydrous and oxygen-free conditions, take 0.5mL sample and test it in ...

Embodiment 2

[0055] Add 1mL of α-butyl cyanoacrylate (the purity is 99.9% as determined by gas chromatography normalization method) to each of ten 2mL ampoules, replace the air inside with high-purity argon, and seal it.

[0056] The above 10 ampoule bottles were labeled as 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 in sequence, and bottle No. 1 was used as a blank control sample without ultraviolet crosslinking. Put bottles 2, 3, 4, 5, 6, 7, 8, 9, and 10 into the heating table in turn, set the temperature at 60°C, adjust the height of the UV lamp shelf to 30cm from the sample, and irradiate with a 2000W UV lamp. According to the time, the time is 10min, 15min, 20min, 25min, 30min, 35min, 40min, 45min, 50min, and finally the viscosity is tested by a rotational viscometer. The viscosity values ​​measured by the main body of the adhesive are shown in Table 2 below:

[0057] Numbering 1 2 3 4 5 6 7 8 9 10 Viscosity / cps 2.3 4.2 10.6 23.5 38.6 112.6 152.3 / / /

Embodiment 3

[0059] Add 1mL of α-hexyl cyanoacrylate (the purity is 99.9% as determined by gas chromatography normalization method) to each of ten 2mL ampoules, replace the air inside with high-purity argon, and seal it.

[0060] The above 10 ampoule bottles were labeled as 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 in sequence, and bottle No. 1 was used as a blank control sample without ultraviolet crosslinking. Put bottles 2, 3, 4, 5, 6, 7, 8, 9, and 10 into the heating table in turn, set the temperature at 60°C, adjust the height of the UV lamp shelf to 30cm from the sample, and irradiate with a 2000W UV lamp. According to the time, the time is 10min, 15min, 20min, 25min, 30min, 35min, 40min, 45min, 50min, and finally the viscosity is tested by a rotational viscometer. The viscosity value of the main body of the adhesive is shown in the following table 3:

[0061] Numbering 1 2 3 4 5 6 7 8 9 10 Viscosity / cps 2.2 3.9 8.9 22.9 33.5 67.8 111 136.7 / /

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Abstract

The present invention relates to the field of medical materials. Particularly, the present invention relates to an adhesive of α-cyanoacrylate and a preparation method therefor. An adhesive with desired viscosity is obtained by radiation crosslinking of the above adhesive. The method of the invention has a simple process and a short production cycle. The α-cyanoacrylate adhesive according to the invention does contain a thickening agent, and has good product homogeneity, a higher safety and a long shelf-life.

Description

technical field [0001] The invention relates to the field of medical materials. Specifically, the present invention relates to an adhesive mainly composed of α-cyanoacrylate and a preparation method thereof. Background technique [0002] Since the American company first introduced the world's first α-cyanoacrylate fast adhesive (abbreviated as α-glue) for bonding skin and hemostasis in 1958, the adhesive with α-cyanoacrylate as the main body has been obtained. Rapid development. It has the following advantages: (1) single-component, solvent-free, and no curing agent; (2) possesses physical properties compatible with natural tissues; (3) stable chemical properties, does not degrade harmful substances; (4) good Biocompatibility, that is, mechanical compatibility and tissue compatibility, low toxicity, no carcinogenicity, no teratogenicity, no mutagenicity, no hemolysis, no pyrogen, low cytotoxicity, no sensitization, no stimulation, no carcinogenesis, itself The advantages ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J135/04C08F122/32C08F222/32C08F2/46
CPCC08F122/32C09J135/04C08F222/324C08F222/326
Inventor 康亚红孙乐青姜洪焱谢志永汪璟候娟罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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