Method for detecting m-benzene dimethyl isophthalate-5-sodium sulfonate purity by liquid chromatography
A technology of dimethyl isophthalate and liquid chromatography, which is applied in the field of instrumental analysis, can solve the problems of not being able to further reflect the internal quality of the product, not being able to play a guiding role in quality improvement, and difficult to vaporize, so as to achieve the best separation effect, The effect of small error and long time consumption
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Embodiment 1
[0031] 1. Instruments used:
[0032] (1) FL2200 liquid chromatograph with UV detector, N2000 chromatographic workstation
[0033] (2) Column Kromstar C18 4.6×150mm 5μm
[0034] (3) Constant temperature column box: Ripley RPL-C2000
[0035] (4) Ultrasonic degassing device
[0036] 2. Detection conditions:
[0037] (1) Mobile phase:
[0038] a. Water (containing 0.05% tetrabutylammonium chloride by volume);
[0039] b. Methanol;
[0040] Mobile phase ratio V a :V b =40:60
[0041] (2) Detection wavelength: 220nm
[0042] (3) Flow rate: 0.8mL / min
[0043] (4) Injection volume: 20μL
[0044] (5) Column temperature: 30°C
[0045] 3. Sample processing:
[0046] Accurately weigh 0.01g of dimethyl isophthalate-5-sodium sulfonate, dissolve it with distilled water, set the volume in a 100mL volumetric flask after cooling, filter through an aqueous membrane, and degas for later use.
[0047] 4. Filter the prepared mobile phase through a 0.45 μm membrane first, then degas it...
Embodiment 2
[0055] 1. Instruments used:
[0056] (1) FL2200 liquid chromatograph with UV detector, N2000 chromatographic workstation
[0057](2) Column Kromstar C18 4.6×150mm 5μm
[0058] (3) Constant temperature column box: Ripley RPL-C2000
[0059] (4) Ultrasonic degassing device
[0060] 2. Detection conditions:
[0061] (1) Mobile phase: a. Water (containing 0.05% tetrabutylammonium chloride by volume); b. Acetonitrile; Mobile phase ratio V a :V b =80:20
[0062] (2) Detection wavelength: 220nm
[0063] (3) Flow rate: 0.8mL / min
[0064] (4) Injection volume: 20μL
[0065] (5) Column temperature: 30°C
[0066] 3. Sample processing:
[0067] Accurately weigh 0.01g of dimethyl isophthalate-5-sodium sulfonate, dissolve it with distilled water, set the volume in a 100mL volumetric flask after cooling, filter through an aqueous membrane, and degas for later use.
[0068] 4. Filter the prepared mobile phase through a 0.45 μm membrane first, then degas it by ultrasonic for 15 minut...
Embodiment 3
[0076] 1. Instruments used:
[0077] (1) FL2200 liquid chromatograph with UV detector, N2000 chromatographic workstation
[0078] (2) Column Kromstar C18 4.6×150mm 5μm
[0079] (3) Constant temperature column box: Ripley RPL-C2000
[0080] (4) Ultrasonic degassing device
[0081] 2. Detection conditions:
[0082] (1) Mobile phase: a. 50mmol / L sodium dihydrogen phosphate solution (containing 0.05% tetrabutylammonium chloride by volume); b. methanol (chromatographically pure); mobile phase ratio V a :V b =40:60
[0083] (2) Detection wavelength: 220nm
[0084] (3) Flow rate: 0.8mL / min
[0085] (4) Injection volume: 20μL
[0086] (5) Column temperature: 30°C
[0087] 3. Sample processing:
[0088] Accurately weigh 0.01g of dimethyl isophthalate-5-sodium sulfonate, dissolve it with mobile phase a by slightly heating, after cooling, set the volume in a 100mL volumetric flask, filter through an aqueous membrane, and degas for later use.
[0089] 4. Filter the prepared mob...
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