Degradable zinc-based alloy bracket and preparation method thereof

A technology for degrading polymers and alloys, which is applied in medical science, prostheses, coatings, etc., can solve problems that have not been reported before, and achieve the effect of easy intervention placement, easy intervention, and improved biocompatibility

Active Publication Date: 2015-08-26
LEPU MEDICAL TECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, zinc-based alloys are rarely reported as degradable metal materials. After searching the literature of the prior art, D Vojtěch et al. reported the mechanical properties and corrosion properties of Zn-Mg alloys, and discussed their application in orthopedic implants. Feasibility of application (Acta biomaterialia,2011,7(9):3515-3522); PK...

Method used

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  • Degradable zinc-based alloy bracket and preparation method thereof
  • Degradable zinc-based alloy bracket and preparation method thereof
  • Degradable zinc-based alloy bracket and preparation method thereof

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preparation example Construction

[0037] The flow chart of the preparation method of a degradable zinc-based alloy stent according to the embodiment of the present invention is as follows: figure 1 shown, including the following steps:

[0038] 1) Process the degradable zinc-based material into a stent matrix; the zinc-based material is composed of pure zinc or zinc-based alloy material, and can be processed into a vascular stent, a tracheal stent, an esophageal stent, an intestinal stent, a biliary stent or a urethral stent matrix etc.

[0039] 2) The stent matrix is ​​pretreated to remove processing residues and surface appendages; including a) performing mechanical treatment on the stent matrix; b) pickling or alkali cleaning the mechanically treated stent matrix; c) acid-washing or alkali-washing The stent matrix after cleaning is ultrasonically cleaned.

[0040] The step of mechanically treating the bracket base body is to use physical methods to remove residual burrs and the like after hollowing out. ...

Embodiment 1

[0056] A novel degradable zinc-based alloy stent in the present invention comprises a degradable zinc-based material stent base and a degradable polymer elution coating containing therapeutic drugs on the surface of the stent base; wherein the degradable zinc-based material is Zn -1% Mg alloy, the therapeutic drug is rapamycin, the degradable polymer is polylactic acid, the organic solvent for preparing the degradable polymer solution is chloroform, and the thickness of the elution coating is 30 μm.

Embodiment 2

[0058] A novel degradable zinc-based alloy stent in the present invention comprises a stent matrix of degradable zinc-based material and a degradable polymer eluting coating containing therapeutic drugs on the surface of the stent matrix. Among them, the degradable zinc-based material is Zn-1%Mg-0.5%Ca alloy, the therapeutic drug is rapamycin, the degradable polymer is polylactic acid, the organic solvent for preparing the degradable polymer solution is chloroform, and the coating is eluted The thickness is 30 μm.

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Abstract

The invention relates to a degradable zinc-based alloy bracket and a preparation method thereof. The bracket includes a degradable zinc-based material bracket substrate; the surface of the bracket substrate is provided with a degradable polymer eluting coating containing treatment drug; the bracket substrate is a cylindrical mesh structure. The preparation method includes: 1) processing the degradable zinc-based material to be a bracket substrate; 2) performing the surface pretreatment on the bracket substrate; 3) performing electrochemical polishing treatment on the bracket substrate; 4) after the treatment, coating a degradable high polymer material carrying with treatment drug on the surface of the bracket. For the substrate material zinc alloy has excellent corrosive resistance, the bracket provided by the invention keeps good supporting property after implanting for 4 months above; the substrate surface is coated with the polymer coating with good biocompatibility, thus the improved compatibility of the zinc-based alloy is good for the coverage of endothelial cells at the surface of the bracket; the drug release can be controlled, and drug burst release is reduced, so that the drug can be released slowly and sustainably with a certain concentration, so as to reduce the local inflammation, restenosis and stent thrombosis risk after implanting the bracket.

Description

technical field [0001] The invention relates to a biodegradable metal bracket and a preparation method thereof, belonging to the technical field of implantable medical devices. Background technique [0002] In 1977, Gruentzing successfully performed the first case of percutaneous transluminal coronary angioplasty, which opened the era of simple balloon dilatation for cardiovascular treatment. This new technology without thoracotomy ended the dominance of coronary blood supply in cardiac surgery History of reconstruction. In 1987, Sigwart successfully implemented coronary artery stent surgery for the first time. A large number of clinical experiments confirmed that coronary artery stent implantation can effectively avoid the medical disadvantages of simple balloon expansion, and it was widely accepted as the second milestone in the history of interventional treatment of coronary heart disease. . After the coronary artery stent is implanted, it can maintain a support state f...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/54A61L27/34A61L27/04
Inventor 刘西伟杨映红蒲忠杰武楠崔凯杨明
Owner LEPU MEDICAL TECH (BEIJING) CO LTD
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