Degradable zinc-based alloy bracket and preparation method thereof

Abstract

The invention relates to a degradable zinc-based alloy bracket and a preparation method thereof. The bracket includes a degradable zinc-based material bracket substrate; the surface of the bracket substrate is provided with a degradable polymer eluting coating containing treatment drug; the bracket substrate is a cylindrical mesh structure. The preparation method includes: 1) processing the degradable zinc-based material to be a bracket substrate; 2) performing the surface pretreatment on the bracket substrate; 3) performing electrochemical polishing treatment on the bracket substrate; 4) after the treatment, coating a degradable high polymer material carrying with treatment drug on the surface of the bracket. For the substrate material zinc alloy has excellent corrosive resistance, the bracket provided by the invention keeps good supporting property after implanting for 4 months above; the substrate surface is coated with the polymer coating with good biocompatibility, thus the improved compatibility of the zinc-based alloy is good for the coverage of endothelial cells at the surface of the bracket; the drug release can be controlled, and drug burst release is reduced, so that the drug can be released slowly and sustainably with a certain concentration, so as to reduce the local inflammation, restenosis and stent thrombosis risk after implanting the bracket.

Description

technical field [0001] The invention relates to a biodegradable metal bracket and a preparation method thereof, belonging to the technical field of implantable medical devices. Background technique [0002] In 1977, Gruentzing successfully performed the first case of percutaneous transluminal coronary angioplasty, which opened the era of simple balloon dilatation for cardiovascular treatment. This new technology without thoracotomy ended the dominance of coronary blood supply in cardiac surgery History of reconstruction. In 1987, Sigwart successfully implemented coronary artery stent surgery for the first time. A large number of clinical experiments confirmed that coronary artery stent implantation can effectively avoid the medical disadvantages of simple balloon expansion, and it was widely accepted as the second milestone in the history of interventional treatment of coronary heart disease. . After the coronary artery stent is implanted, it can maintain a support state f...

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Problems solved by technology

However, zinc-based alloys are rarely reported as degradable metal materials. After searching the literature of the prior art, D Vojtěch et al. reported the mechanical properties and corrosion properties of Zn-Mg alloys, and discussed their application in orthopedic implants. Feasibility of application (Acta biomaterialia,2011,7(9):3515-3522); PK Bowen et al. reported the implantation experiment of pure zinc in the abdominal aorta of mice, revealed its corrosion characteristics in vivo, and discussed the role of pure Zn as Feasibility of metal materials for stents (Advanced Materials,2013,25(18):2577-2582), however, the design of stents that can degrade zinc and its alloys has not been reported

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