Preparation method of monodisperse porous silicon dioxide microspheres

Abstract

The invention discloses a preparation method of monodisperse porous silicon dioxide microspheres, which comprises the following steps: hydrolyzing ethyl orthosilicate under alkaline conditions to generate nano solid silicon dioxide microspheres, and carrying out hydrothermal treatment to implement solid-to-porous transition, thereby obtaining the monodisperse porous silicon dioxide microsphere material with controllable microsphere diameter / pore size and favorable biocompatibility. The preparation method is simple, and has the advantages of mild reaction conditions and no harm to the environment. The prepared porous silicon dioxide microspheres have favorable monodispersity and biocompatibility, and can be widely used in the fields of biomedicine, catalytic carriers and the like.

Description

technical field [0001] The invention relates to material synthesis and preparation technology, in particular to a preparation method of monodisperse porous silica microspheres. Background technique [0002] Since Kresge and other scientists of Mobil Corporation successfully synthesized the M41S series of ordered mesoporous silica materials using cationic surfactants as templates in 1992, due to their advantages such as high specific surface area and ordered pore distribution, they have been widely used in biomedicine. And catalytic materials and other fields have extremely broad application prospects, and porous materials represented by it have rapidly become a research hotspot in the field of materials at home and abroad. [0003] Generally, porous silica materials use surfactant molecular aggregates as templates, and tetraethyl orthosilicate as a silicon source. In aqueous solution, surfactant self-assembled micelles and tetraethyl orthosilicate interfaces are assembled in...

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Problems solved by technology

For example, DechaoNiu et al. used the block copolymer PS-b-PAA and cetyltrimethylammonium bromide (CTAB) dual templates to prepare macroporous silica and used it in the field of drug delivery (Niu D, Liu Z , Li Y, et al.[J].Advanced Materials, 2014), but this method uses the traditional template agent CTAB, CTAB is a quaternary ammonium salt cationic surfactant, which has high biological toxicity, which limits the use of this surfactant Applications of Synthetic Porous Materials

[0004] In the Chinese patent literature, Chen Tiehong et al. (CN1923684A) used a less toxic anionic surfactant (sodium lauryl sarcosinate) as a template to prepare mesoporous silica, but the particle size of the prepared mesoporous silica Inhomogeneous, and can only be mesoporous with a pore size of ~3nm, and, due to the use of structure-directing agents such as (3-aminopropyl)trimethoxysilane, many reactants are used, and the preparation process is complicated, which greatly limits the The preparation and application of the material

Dai Zhao et al. (CN 102351200A) used organic polymer microspheres of small particle size as pore-forming agents, and finally used solvent or calcination to remove internal organic templates to prepare macroporous silica microspheres; due to the use of organic polymer microspheres The ball is used as a template, so it is necessary to use solvent or calcination to remove this template, which leads to the toxicity of this method, which is not environmentally friendly, and consumes a lot of energy. It is difficult to show the value of this method in practical applications.

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