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Mg-Ca-Sr-Zn magnesium alloy as well as preparation method and application thereof

A magnesium alloy, medical technology, applied in the field of Mg-Ca-Sr-Zn series magnesium alloy and its preparation, can solve the problems of low corrosion resistance and so on

Active Publication Date: 2015-09-16
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of magnesium in engineering applications is low corrosion resistance, but this disadvantage has become its advantage as a biomaterial: magnesium can be degraded into soluble non-toxic oxides in the body and excreted harmlessly from intestinal tissue outside the body

Method used

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  • Mg-Ca-Sr-Zn magnesium alloy as well as preparation method and application thereof
  • Mg-Ca-Sr-Zn magnesium alloy as well as preparation method and application thereof
  • Mg-Ca-Sr-Zn magnesium alloy as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Embodiment 1, preparation cast state Mg-Ca-Sr-Zn series magnesium alloy

[0090] The test raw materials are pure Mg (99.7wt%), Ca powder (99.8wt%), Sr powder (99.9wt%) and Zn powder (99.5wt%), according to different proportions, as shown in Table 1, at 670 ° C , smelting under the protective atmosphere of Ar gas (99.99%), after the experimental material is fully melted, it is kept for 40 minutes, and then the molten material is poured into the pre- In the designed mold, as-cast Mg-Ca-Sr-Zn magnesium alloys with different proportions were prepared.

[0091] Table 1, the Mg-1Ca-xSr-yZn series magnesium alloy prepared in Example 1

[0092] sample

x value

y value

sample

x value

y value

Sample 1-1

0.2

2

Sample 1-7

1

2

Sample 1-2

0.2

4

Sample 1-8

1

4

Sample 1-3

0.2

6

Samples 1-9

1

6

Sample 1-4

0.5

2

Samples 1-10

2

2

Sample 1-5

0....

Embodiment 2

[0095] Embodiment 2, preparation extruded state Mg-Ca-Sr-Zn series magnesium alloy

[0096] Firstly, the as-cast Mg-1Ca-xSr-yZn alloy ingots of different proportions are prepared according to the steps in Example 1 (the proportioning ratio is shown in Table 1), and then all are processed as follows: the ingot is processed into Φ39.6mm× 50mm size, solid solution treatment at 340°C for 4 hours; preheat the ingot to 340°C and keep it warm for 20 minutes, the temperature of the mold and the extrusion cylinder are both 295°C, the extrusion temperature is 320°C, and the extrusion speed is 2mm / s, the extrusion ratio was 16, and the extruded Mg-1Ca-xSr-yZn magnesium alloy (sample 2-12) was prepared, as shown in Table 2.

[0097] Table 2 Example 2 prepared Mg-1Ca-xSr-yZn series magnesium alloy

[0098] sample

x value

y value

sample

x value

y value

Sample 2-1

0.2

2

Sample 2-7

1

2

Sample 2-2

0.2

4

Sample 2-8

...

Embodiment 3

[0101] Embodiment 3, performance test of Mg-Ca-Sr-Zn series magnesium alloy

[0102] (1) Tensile properties at room temperature

[0103] The extruded Mg-Ca-Sr-Zn series magnesium alloy (sample 1-12) prepared in Example 2 was all prepared according to the ASTM-E8-04 tensile test standard, and the SiC sandpaper was polished to 2000# , using a general material tensile testing machine to carry out the tensile test at room temperature, the tensile speed is 0.5mm / min, the results are as follows image 3 shown.

[0104] Depend on image 3 It can be seen that the yield strength of the extruded Mg-Ca-Sr-Zn series magnesium alloy is 100-150 MPa, the tensile strength is 125 MPa-250 MPa, and the elongation at break is 2%-35%. When the Sr content is 0.2wt.% and 1wt.%, the yield strength and tensile strength of the alloy increase with the increase of Zn content, but the elongation at break of the alloy decreases with the increase of Zn content in the alloy . When the Sr content was 0.5...

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Abstract

The invention discloses an Mg-Ca-Sr-Zn magnesium alloy as well as a preparation method and application thereof. The Mg-Ca-Sr-Zn magnesium alloy consists of Mg, Ca, Sr and Zn in percentage by mass, wherein the content of Ca is 0-5% but not 0, the content of Sr is 0-5% but not 0, the content of Zn is 0-10% but not 0, and the remnants are Mg. Due to cooperation of component design and preparation process, the purposes of conditioning and controlling the mechanical property and the decomposition velocity of medical implants can be achieved, optimal mechanical property and corrosion resistance can be achieved, relatively good biocompatibility can be achieved, the Mg-Ca-Sr-Zn magnesium alloy has the main characteristic of relatively high cell survival rate, relatively high ALP activity and good erythrocyte and hemoglobin compatibility, and the cell survival rate is not remarkably reduced along with the culture time; metal elements essential for human bodies are adopted, no harmful element or element with potential harm is used, and the alloying element Sr can promote osteogenesis and inhibit bone resorption, so that along with decomposition of the Mg-Ca-Sr-Zn magnesium alloy, tissue heal can be promoted while Sr is partially released.

Description

technical field [0001] The invention relates to a Mg-Ca-Sr-Zn series magnesium alloy and its preparation method and application, in particular to a Mg-Ca-Sr-Zn series magnesium alloy and its preparation method and its use in the preparation of body fluid degradable medical implants The application in the present invention belongs to the field of medical metal material preparation. Background technique [0002] At present, biodegradable materials widely used clinically are mainly degradable polymer materials, degradable ceramic materials and degradable metal materials. Degradable polymer materials include polylactic acid (PLA), polycaprolactone (PCL), polyglycolic acid (PGA) and polylactic-co-glycolic acid (PLGA), as well as natural polysaccharides (cellulose, chitin) and natural Protein materials (collagen, fibrin), etc. Degradable ceramic materials mainly include hydroxyapatite (HA) and β-tricalcium phosphate. Although degradable polymer materials can be completely absor...

Claims

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Application Information

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IPC IPC(8): C22C23/04C22C23/00C22F1/06A61L31/02A61L31/10A61L31/08A61L31/14
Inventor 郑玉峰吴远浩李楠刘洋成艳
Owner PEKING UNIV
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