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Medicine composite for treating child adhesive intestinal obstruction and preparation method thereof

A technology for adhesive intestinal obstruction and a composition, which is applied in the field of pharmaceutical preparations, can solve problems such as lack of targeted therapeutic drugs, cure the symptoms but not the root cause, and affect appetite, and achieve the effects of no toxic side effects, definite curative effect, and short treatment course.

Inactive Publication Date: 2015-10-21
杜国强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no specific drug for the treatment of adhesive intestinal obstruction in children, and it affects appetite, which is not a cure for the symptoms

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0067] When the dosage form of the pharmaceutical composition is a granule, its preparation method comprises the following steps:

[0068] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 85% to 95% that is 4 to 8 times that of the mixture, heat to boiling and reflux for 3 to 5 hours, and filter. Use the percolation method to percolate slowly at a rate of 1-2ml per minute, collect the percolation liquid, and then concentrate under reduced pressure at a vacuum of 0.06-0.09Mpa to a paste with a relative density of 1.04-1.10 at 50-60°C. Spray drying, the air inlet temperature of the spray dryer is 160-175°C, the outlet air temperature is 80-85°C, and then crushed into powder to make dry paste powder;

[0069] In the second step, 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin are added to the obtained dry paste powder to form granules, and dried at 40-50° C. to obt...

Embodiment 1

[0078] Example 1 Granules

[0079] The preparation process of the granules of the present invention is as follows: get red cohosh 140g, oriental salamander 300g, hemp seed 180g, green bark 350g, comfrey 160g, fleece-flower root 250g, andrographis 150g, cistanche 350g, fusuoma 210g, betel 240g, 300g Fengfengsan, 150g Shenjincao, 130g Radix Paeoniae Rubra, 250g Hubei Begonia, 170g Radish Seed, 220g Curcuma, 150g Angelica, 300g Brassica Seed, 120g Cassia Seed, 320g Arrowhead Wind, 450g Upper Fruit Leaf, 140g Niu Xixi, 330g of bamboo poles, 220g of citrus and 130g of Myxophyllum brownus;

[0080] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 90% that is 5 times that of the mixture, heat to boiling and reflux for 4 hours, filter, and use the percolation method at a rate of 90% per minute. Slowly percolate at a speed of 1.5ml, collect the percolation liquid, then concentrate u...

Embodiment 2

[0082] Example 2 Capsules

[0083] The manufacture process of the capsule of the present invention is: get red cohosh 150g, oriental salamander 260g, hemp seed 160g, green bark 280g, comfrey 140g, Polygonum multiflorum 320g, Andrographis 150g, Cistanche 400g, Husuoma 300g, betel 250g, 320g Fengfengsan, 250g Shenjincao, 200g Radix Paeoniae Rubra, 280g Hubei Begonia, 220g Radish Seed, 220g Curcuma, 150g Angelica, 330g Brassica Seed, 150g Cassia Seed, 270g Arrowwind, 420g Upper Fruit Leaf, 150g Niu Xixi, 240g of bamboo poles, 150g of citrus and 280g of Myxophyllum brownus;

[0084] The first step is to mix the raw materials of the pharmaceutical composition in proportion, add ethanol with an alcohol concentration of 95% that is 3 times the mass of the mixture, heat and reflux for 2 hours, extract, and filter to obtain the first extract; Then add ethanol with an alcohol concentration of 95% to the dregs of the dregs, heat and reflux for 2 hours, extract, and filter to obtain the ...

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Abstract

The invention discloses a medicine composite for treating child adhesive intestinal obstruction and a preparation method thereof. The medicine composite is composed of astilbe chinensis, ovate leaf holly barks, cynops orientalis, fructus cannabis, cynomorium songaricum, pericarpium citri reticulatae viride, lithospermum erythrorhizon, polygonum multiflorum, argemone mexicana, andrographis paniculata, cistanche, helicteres isora, piper hancei, oblongleaf kadsura stem roots, lycopodium clavatum, red paeony roots, malus hupehensis, cornutcd pugionium. The medicine composite has the advantages that the medicine composite is effective in invigorating the blood circulation, moistening the intestines, removing food retention and qi stagnation, promoting qi circulation and relieving pains, the effects of removing the heat, cooling the blood, promoting digestion, eliminating abdominal distention and resisting against infection are achieved simultaneously, the medicine composite is mainly used for treating the abdominal distention caused after a resection operation, and the effect is achieved fast, the curative effect is definite, the treatment course is short, no toxic and side effect exists, and the cost is low.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating adhesive intestinal obstruction in children and a preparation method thereof. Background technique [0002] Adhesive ileus is extensive intestinal adhesions formed after abdominal surgery, inflammation, and trauma. Acute intestinal obstruction caused by adhesive bands is the most common type of intestinal obstruction. Most patients have a history of abdominal surgery, inflammation, trauma, or tuberculosis, before the onset of overeating or strenuous exercise incentives; in the past, they often had abdominal pain or had a history of medical treatment due to intestinal adhesions. A small number of intra-abdominal congenital cords are more common in children. [0003] The etiology of adhesive intestinal obstruction: intestinal adhesions and intra-abdominal adhesions can be divided into two types: congenital and acquire...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P1/00A61K35/65
Inventor 杜国强颜瑞
Owner 杜国强
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