Polyurethane-based cellular material compounding vessel growth promotion factors and preparation method of polyurethane-based cellular material

A technology of vascular growth factor and polyurethane, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of loss of biological activity and short half-life, and achieve the effect of promoting skin tissue repair, promoting wound angiogenesis, and good repeatability

Active Publication Date: 2015-11-11
杭州承前医数科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the half-life of these growth factors in the body is very short, and they will be degraded within a few minutes and lose their biological activity. Therefore, the key to solving their application is to obtain a sustained release system for growth factors

Method used

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  • Polyurethane-based cellular material compounding vessel growth promotion factors and preparation method of polyurethane-based cellular material
  • Polyurethane-based cellular material compounding vessel growth promotion factors and preparation method of polyurethane-based cellular material
  • Polyurethane-based cellular material compounding vessel growth promotion factors and preparation method of polyurethane-based cellular material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Preparation of polyurethane prepolymer: Add 150g ethylene oxide / propylene oxide random polymer (average molecular weight 2kD, ethylene oxide content 80%) and 18g toluene diisocyanate into a round bottom flask, Mechanically stir and mix evenly, heat to 60° C., and react for 6 hours to generate a polyurethane prepolymer with isocyanate end groups. In an intermediate stage of the reaction, the product is sampled and the content of isocyanate groups is determined according to the titration method using n-butylamine standard solution.

[0038] (2) Preparation of polyurethane porous material of complex glycosaminoglycan: mix 50wt% of polyurethane prepolymer obtained in step (1), 39wt% of distilled water as foaming agent, 10wt% of sorbitol as crosslinking agent and 1wt% heparin (use after making 10mg / mL solution). The resulting mixture was stirred at a speed of 3000 rpm for 30 seconds, transferred to a pre-shaped mold, and foamed at 40°C for 15 minutes to obtain a polyure...

Embodiment 2

[0041]Step (1) Preparation of polyurethane prepolymer: The isocyanate used is diphenylmethane diisocyanate, xylene diisocyanate or hexamethylene diisocyanate, and the others are the same as in Example 1.

Embodiment 3

[0043] Step (1) Preparation of polyurethane prepolymer: a random polymer of ethylene oxide and propylene oxide (the average molecular weight is 2kD, and the content of ethylene oxide is 50%). Others are the same as in Example 1.

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Abstract

The invention discloses a polyurethane-based cellular material compounding vessel growth promotion factors and a preparation method of the polyurethane-based cellular material. The polyurethane-based cellular material is obtained by arranging a polyurethane-based cellular material compounding glycosaminoglycan in a phosphate buffered solution containing 0.1 to 3 microgram/mL of the vessel growth promotion factors, soaking for 1 to 120 minutes under the temperature of 4 to 37 DEG C, then repeatedly rinsing for multiple times with the phosphate buffered solution, and freeze-drying, wherein each rinsing lasts for 1 to 120 minutes. The polyurethane-based cellular material compounding the vessel growth promotion factors has the advantages of having good air permeability and hygroscopicity, promoting wound vessel regeneration and skin tissue repair, reducing scar formation and the like.

Description

technical field [0001] The invention relates to a polyurethane-based porous material, in particular to a polyurethane-based porous material compounded with angiogenesis-promoting factors and a preparation method thereof. Background technique [0002] Burns, wounds or ulcers of the skin are very common surgical conditions. Skin defects can affect the patient's appearance in mild cases, and in severe cases can cause infection or a large loss of electrolytes and water, leading to the death of the patient. Although skin tissue has a strong regenerative ability, for large-area full-thickness skin defects, the ability of the skin to spontaneously regenerate is insufficient, and scar tissue is often formed instead of normal skin. So far, autologous skin grafting is still the most effective method for clinical treatment of full-thickness skin defects. However, this method faces the shortcomings of insufficient supply of autologous skin and secondary damage to the patient. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08J9/14C08J3/24C08L75/08C08L5/08C08L5/10C08G18/48C08G18/10A61L15/28A61L15/26A61L15/42A61L15/44
Inventor 毛峥伟张匀吴炜卢承志
Owner 杭州承前医数科技有限公司
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