Polyethylene glycol modified Bi nano photothermal conversion material as well as preparation method and application thereof

A photothermal conversion material, polyethylene glycol technology, applied in the field of biomedicine, can solve the problems of complex synthesis process, photothermal conversion performance, photothermal stability and biological safety to be improved, and achieves low cytotoxicity, ideal Photothermal treatment effect, strong absorption effect

Active Publication Date: 2016-03-23
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention is to solve the problem of existing developed inorganic light-to-heat conversion materials (such as gold nanorods, gold nanoshells, carbon nanotubes, Cu 9 S 5 Nanocrystals, etc.) photothermal conversion performan

Method used

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  • Polyethylene glycol modified Bi nano photothermal conversion material as well as preparation method and application thereof
  • Polyethylene glycol modified Bi nano photothermal conversion material as well as preparation method and application thereof
  • Polyethylene glycol modified Bi nano photothermal conversion material as well as preparation method and application thereof

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Experimental program
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Example Embodiment

[0028] Specific embodiment 1: This embodiment is a polyethylene glycol-modified bismuth nano-photothermal conversion material, which is prepared by using surfactant, bismuth salt, polyacrylamine hydrochloride aqueous solution, polyacrylic acid aqueous solution and crosslinking agent as raw materials The bismuth nano-photothermal conversion material modified by polyethylene glycol has a particle size of 20 nm to 200 nm, and the bismuth nano-photothermal conversion material modified by polyethylene glycol has a photothermal conversion efficiency of 25% to 35%. .

[0029] The preparation of the polyethylene glycol-modified bismuth nano-photothermal conversion material in this embodiment is carried out according to the following steps:

[0030] 1. Add the surfactant to the solvent, mix well under the condition of mechanical stirring, then add the bismuth salt to it, continue to stir and mix uniformly to obtain a reaction mixture, heat the reaction mixture from room temperature to 50℃~1...

Example Embodiment

[0033] Specific embodiment two: this embodiment is different from specific embodiment one in that: the surfactant is one or a mixture of several of α-D-glucose, maltose, ribose and polyvinylpyrrolidone PVP; The solvent is one or a mixture of 1,2-propylene glycol, ethylene glycol and water; the bismuth salt is one or a mixture of several of bismuth nitrate, bismuth acetate and bismuth chloride; the reduction The agent is one or a mixture of morpholine borane solution, sodium borohydride solution and hydroxylamine solution; the concentration of the reducing agent is (10-40) mg / mL; the crosslinking agent A is 1 -(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride solution and glutaraldehyde solution one or two mixtures; the crosslinking agent B is 1-(3- One or a mixture of dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride solution and glutaraldehyde solution. Others are the same as the first embodiment.

Example Embodiment

[0034] Specific implementation mode 3: In this embodiment, a method for preparing a polyethylene glycol-modified bismuth nano-photothermal conversion material is performed according to the following steps:

[0035] 1. Add the surfactant to the solvent, mix well under the condition of mechanical stirring, then add the bismuth salt to it, continue to stir and mix uniformly to obtain a reaction mixture, heat the reaction mixture from room temperature to 50℃~150℃, Add reducing agent to the reaction mixture under the condition of 50℃~150℃, react for 0.5min~5min, after the reaction, put it in an ice bath to cool to room temperature, centrifuge and wash 1~5 times, collect the sample and freeze dry to obtain bismuth Nanoparticle materials; the mass ratio of the bismuth salt to the surfactant is 1: (10-30); the mass ratio of the bismuth salt to the solvent is 1 g: (150-250) mL; the reaction mixture is The volume ratio of reducing agent is 1:(0.1~0.2);

[0036] 2. Dissolve the bismuth nanop...

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Abstract

The invention relates to the field of biomedicine, particularly to a polyethylene glycol modified Bi nano photothermal conversion material as well as a preparation method and an application thereof, and aims to solve problems that photothermal conversion performance, photothermal stability and biosecurity of existing developed inorganic photothermal conversion materials (such as gold nano-rods, gold nano-shells, carbon nano-tubes, Cu9S5 nanocrystals and the like) need to be improved and synthetic processes are relatively complex. The particle size of the polyethylene glycol modified Bi nano photothermal conversion material is 20-200 nm, and the photothermal conversion efficiency of the polyethylene glycol modified Bi nano photothermal conversion material is 25%-35%. The method comprises steps as follows: I, a Bi nanoparticle material is prepared; II, the Bi nanoparticle material is coated. The polyethylene glycol modified Bi nano photothermal conversion material as a photothermal conversion nanomaterial is used for photothermal therapy of malignant tumors.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a polyethylene glycol-modified bismuth nano-photothermal conversion material, its preparation method and application. Background technique [0002] With the acceleration of people's life rhythm, the increase of pressure and the increasing pollution of the natural environment, the incidence of malignant tumors (cancer) is increasing year by year, which seriously threatens the life and health of human beings. At present, conventional cancer treatment methods mainly include surgical resection, drug chemotherapy, and physical radiation therapy. Although they all have certain therapeutic effects, they have inherent limitations in the actual clinical treatment of cancer (especially advanced cancer). It cannot be ignored, mainly manifested in extremely toxic and side effects, lack of targeting and very limited therapeutic effect. Therefore, there is an urgent need to find a safe, efficient a...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/48A61P35/00
CPCA61K41/00
Inventor 于淼李正林孙晔范雪蕾李卓
Owner HARBIN INST OF TECH
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