Method for preparing nontoxic antibacterial coating on surface of medical implant material

A technology for implant materials and antibacterial coatings, applied in coatings, pharmaceutical formulations, medical science, etc., can solve problems such as increased cytotoxicity, achieve the effects of increased cell proliferation, consistent particle size, and enhanced biomedical functions

Active Publication Date: 2016-06-01
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the introduction of Ag nanoparticles has the risk of increased cytotoxicity to a certain extent. How to maintain the antibacterial properties of the implant surface and greatly reduce or eliminate toxicity is a major challenge for the surface functionalization of medical biomaterials today, and urgent research is needed. solve

Method used

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  • Method for preparing nontoxic antibacterial coating on surface of medical implant material
  • Method for preparing nontoxic antibacterial coating on surface of medical implant material
  • Method for preparing nontoxic antibacterial coating on surface of medical implant material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of nano-silver / glutin dipeptide composite film by pulse electrodeposition. The 10mm×10mm×2mm pure titanium plate was polished step by step with sandpaper to 1500, and then ultrasonically cleaned with deionized water, acetone, ethanol and deionized water for 10 minutes, and then dried in air. Prepare a 0.5% HF solution as the electrolyte, use the polished titanium plate as the anode, and use the large-area platinum electrode as the cathode to form a two-electrode electrolytic cell. Apply 200r / min mechanical stirring to the system, keep the water bath at constant temperature, and control the system temperature to room temperature, about 25°C. A stabilized power supply was used to provide power to the electrolytic cell for electrochemical anodic oxidation at a constant voltage of 20V for 20 minutes.

[0038] Electrolyte containing AgNO 3 0.01mol / L, NaNO 3 0.1mol / L, the concentration of CG dipeptide is 0.05mol / L, the anodized titanium plate is used as the wor...

Embodiment 2

[0040] Silver mirror reaction to prepare nano-silver / glutamic acid dipeptide composite film. The pretreatment method and electrochemical anodizing treatment process of 10mm * 10mm * 2mm pure titanium plates are the same as in Example 1, now add 10ml of silver ammonia solution and add 3ml of 2mol / L glucose solution, and the concentration of glucodipeptide is 0.05mol / L, and anodic oxidation The finished titanium or titanium alloy is immersed in the solution, rinsed with deionized water after reaction, and dried. The anodized titanium or titanium alloy is immersed in the solution, rinsed with deionized water after reaction, and dried. The temperature is controlled at 25 ° C, and the reaction time is 20 minutes. , to obtain a uniform distribution in TiO 2 The Ag nanoparticles in the nanotube orifice and the tube, the Ag nanoparticles particle diameter is 30~60nm (the present invention generally describes this appearance as appearance two, such as figure 2 shown). The size of th...

Embodiment 3

[0042] Preparation of nano-silver / glutamic acid dipeptide composite film by ultraviolet light reduction method. The pretreatment method and electrochemical anodic oxidation treatment process of 10mm × 10mm × 2mm pure titanium plate are the same as in Example 1, and the preparation solution: containing AgNO 3 1mol / L, the concentration of dipeptide is 0.05mol / L, the anodized titanium or titanium alloy is immersed in the solution, rinsed with deionized water, dried, soaked for 10min, and placed in a mercury lamp (200W, 100mW / cm 2 ) under irradiation, and the irradiation time is 10min, and the uniformly distributed TiO 2 The Ag nanoparticles in the nanotube orifice and the tube, the Ag nanoparticles particle diameter 1~10nm (the present invention generally describes this appearance as appearance three, such as image 3 shown). Regulating soaking time and soaking times can control the particle size of Ag nanoparticles within 1-30nm, and the particle size and loading of Ag nanopar...

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Abstract

The invention discloses a method for preparing a nontoxic antibacterial coating on the surface of a medical implant material and relates to a medical implant material. The invention provides the method for preparing the nontoxic antibacterial coating on the surface of the medical implant material, wherein the cytotoxicity of a silver composite membrane layer on the surface of an implant material can be remarkably reduced while excellent antibacterial property is maintained, and the method is mainly applied to the antibacterial modification of the implant surface in bone and tooth replacement and tissue regenerative medicine. The method comprises the following steps: pretreating the to-be-treated medical implant material; preparing a solution containing AgNO3, short peptide and electrolyte or reductive substance; and building a nano silver/short peptide composite membrane layer on the surface of the medical implant material. The cytotoxicity of the nano silver membrane layer on the surface of the implant material can be remarkably reduced while excellent antibacterial property is maintained. The method can be applied to the nontoxic antibacterial modification of the surfaces of multiple implants. The method is simple in technology, requires small investment and can be widely applied to the surface modification of medical implants while large-scale production can be realized.

Description

technical field [0001] The invention relates to medical implant materials, in particular to a method for preparing a non-toxic antibacterial coating on the surface of medical implant materials. Background technique [0002] In recent years, medical implant materials, including medical implants such as titanium and its alloys, stainless steel, ceramics and polymers, have been widely used in surgical implant materials, such as artificial joints, dental implants, vascular stents, bone plates Nails and other implants and medical devices. Bio-inorganic non-metallic composite materials and polymer materials are widely used in human soft and hard tissue restorations, artificial organs, etc. The antibacterial properties of medical implant materials are very important at the initial stage of implantation. As a broad-spectrum antibacterial agent, the introduction of nano-silver into the surface of medical implant materials can effectively improve the antibacterial properties of the m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/28A61L27/54
CPCA61L27/28A61L27/306A61L27/54A61L2300/104A61L2300/252A61L2300/404A61L2300/606A61L2400/06
Inventor 宋然林昌健赵玉芬梁建鹤唐果杨云张艳梅高玉兴付川
Owner XIAMEN UNIV
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