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Biological absorbable foamed magnesium adhesive-matrix type targeted drug slow-release carrier and preparation method

A foam magnesium storage type and drug controlled release technology is applied in the field of foam magnesium storage type targeted drug controlled release carrier and preparation, which can solve the problems of poor mechanical properties, special-shaped carrier forming holes, difficulty and the like, and achieves reliability. High, easily degradable absorption, good biocompatibility

Inactive Publication Date: 2016-08-10
CHONGQING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Other bioceramic or polymer reservoir-type porous drug carriers also have the problems of poor mechanical properties, shape-shaped carriers and difficulties in pore formation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The following steps are adopted to prepare the bioabsorbable foamed magnesium storage type targeted drug controlled release carrier:

[0028] 1) Take 10.5g of polystyrene with a particle size of 300μm as a microsphere pore-forming agent, put it into a polyurethane ball mill tank together with 19.5g of magnesium powder with a median diameter of 120μm and a purity of 99.9%, and put it on a roller ball mill well mixed. Weigh 10 g of the mixture and put it into a mold and press it with a tablet press at 50 MPa to form a compact cylindrical green body with a diameter of φ15×40 mm.

[0029] 2) Place the green body at a pressure lower than 5×10 -3 In a vacuum atmosphere tubular electric furnace of Pa, heat up to 200°C at 2°C / min and keep it warm for 2h; then raise the temperature to 500°C at 5°C / min and keep it warm for 4h; Cool naturally to room temperature under the condition, make the foamed magnesium cylinder;

[0030] 3) Cut the obtained foamed magnesium cylinder into ...

Embodiment 2

[0034] 1) Take 6.0g of polystyrene with a particle size of 800μm as a microsphere pore-forming agent, put it into a polyurethane ball mill tank together with 24.0g of magnesium powder with a median diameter of 180μm and a purity of 99.9%, and put it on a roller ball mill well mixed. Weigh 11 g of the mixture and put it into a mold with a tablet press under 50 MPa to form a dense cylindrical green body with a diameter of φ15×40 mm.

[0035] 2) Place the green body at a pressure lower than 5×10 -3 In a vacuum atmosphere tubular electric furnace of Pa, heat up to 200°C at 2°C / min and keep warm for 2h; then heat up to 500°C at 5°C / min and keep warm for 2h; Cool naturally to room temperature under the condition, make the foamed magnesium cylinder;

[0036]3) Cut the obtained foamed magnesium cylinder into long and short sections at a ratio of 3:1. Use a micro machine tool to bore out the inner hole of φ5×25mm in the long section, process it into a cylinder with a wall thickness ...

Embodiment 3

[0040] 1) Take 15.0 g of polystyrene with a particle size of 153 μm as a microsphere pore-forming agent, put it into a polyurethane ball mill tank together with 15.0 g of magnesium powder with a median diameter of 110 μm and a purity of 99.9%, and place it on a roller ball mill well mixed. Weigh 9.3 g of the mixture, put it into a mold, and press it under 50 MPa with a tablet machine to form a dense cylindrical body with a diameter of φ15×40 mm.

[0041] 2) Place the green body at a pressure lower than 5×10 -3 In a vacuum atmosphere tubular electric furnace of Pa, heat up to 200°C at 2°C / min and keep it warm for 2h; then raise the temperature to 500°C at 5°C / min and keep it warm for 5h; Cool naturally to room temperature under the condition, make the foamed magnesium cylinder;

[0042] 3) Cut the obtained foamed magnesium cylinder into long and short sections at a ratio of 3:1. Use a micro machine tool to bore out the inner hole of φ9×27mm in the long section, process it in...

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Abstract

The invention discloses a biological absorbable foamed magnesium adhesive-matrix type targeted drug slow-release carrier and a preparation method. The carrier comprises a barrel body and a barrel cover, wherein one end of the barrel body is opened and the barrel cover is matched with the opened part; the barrel body is in threaded connection with the barrel cover; the barrel body and the barrel cover are prepared of foamed magnesium materials; communication micropores with pore diameters of 100-500 microns are uniformly distributed in the foamed magnesium materials and are used for slowly releasing drugs. After being filled with drugs, the carrier is implanted into pathological bone tissues, so as to realize the fixed-point controlled release and biodegradable absorption of the drugs and facilitate the ingrowth of new bone tissues. The mechanical properties of the foamed magnesium are similar to the mechanical properties of the natural bones, so that the foamed magnesium can be used at the bearing parts of human body. According to the preparation method, the foamed magnesium is prepared from polystyrene microspheres and magnesium powder by adopting a powder metallurgy method, the foamed magnesium is processed into a barrel with the barrel cover by adopting a machining method so as to form a capsule-shaped drug carrier, and MgF2 chemical conversion coatings with thicknesses of 1-2 microns are generated on the inner and outer surfaces of the carrier; the method is simple, convenient, feasible and high in reliability.

Description

technical field [0001] The invention belongs to the technical field of implantable biomedical drug carriers, and in particular relates to a bioabsorbable foam magnesium storage-type targeted drug controlled release carrier and a preparation method. Background technique [0002] The controlled-release drug delivery system is a new type of preparation that can provide stable and continuous drug delivery, effectively control the blood drug concentration, and overcome the peak-valley phenomenon. In the clinical treatment of human bone cancer, bone tuberculosis and other diseases, it is necessary to use drugs that are effective but highly toxic or prone to toxic side effects such as liver and kidney damage after a large amount of use, to study a bioabsorbable targeted drug control It is very necessary to release the carrier, which is loaded with drugs and implanted into the diseased part of the human body, and only directly and continuously releases the drug to the patient part, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/02
CPCA61K9/0024A61K9/0002A61K47/02
Inventor 王振林万涛闫玉华
Owner CHONGQING UNIV OF TECH
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