Preparation method of monodispersed selenium doped nano hydroxyapatite

A nano-hydroxyapatite and selenium doping technology, which is applied in nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problem of uneven shape and size of nanoparticles, uneven shape and scale of products, and complicated preparation process, etc. problems, to achieve the effect of uniform shape and size, good application prospects, and easy access to raw materials

Inactive Publication Date: 2016-11-02
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the selenium-doped nano-hydroxyapatite reported in the literature is mainly obtained by sintering, and the prepared product is obtained after crushing; a patent CN 102249206 A discloses a selenium-doped hydroxyapatite and its preparation method , the method uses sodium polyacrylate as a dispersant, and adopts a step-by-step method to prepare nano-scale selenium-doped hydroxyapatite under the conditions of pH 10-10.5 and 75-80 ° C. The prepared nano-crystalline particle size distribution width is 20-60nm, the length distribution width is 80-150nm, the product shape scale is not uniform, and the agglomeration is serious
The inhomogeneous shape and size of selenium-doped hydroxyapatite nanoparticles and the complicated preparation process have brought great limitations to practical applications.

Method used

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  • Preparation method of monodispersed selenium doped nano hydroxyapatite
  • Preparation method of monodispersed selenium doped nano hydroxyapatite
  • Preparation method of monodispersed selenium doped nano hydroxyapatite

Examples

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Embodiment 1

[0020] Step 1: In a 40mL polytetrafluoroethylene hydrothermal reaction kettle, dissolve 0.5g of polyethylene glycol 2000 in 7.5mL of 0.25M calcium nitrate aqueous solution, stir for several minutes, then add 16mL of ethanol, 4mL of Oleic acid, 0.45mL of 0.25M sodium selenite aqueous solution and 6.75mL of 0.15M trisodium phosphate solution were stirred evenly at room temperature;

[0021] Step 2: Seal the reaction vessel, react at 120°C for 10 hours, then cool naturally to room temperature, open the reaction vessel, and wash several times with cyclohexane, ethanol and water successively to obtain the final product.

[0022] figure 1 It is a transmission electron microscope image of the selenium-doped hydroxyapatite nanorod, and it can be seen from the figure that the prepared nanoparticle is rod-shaped, with a width of about 9 nm and a length of about 180 nm. figure 2 It is the X-ray diffraction pattern of the nanoparticles, and it can be seen from the figure that the obtain...

Embodiment 2

[0024] Step 1: In a 40mL polytetrafluoroethylene hydrothermal reaction kettle, dissolve 0.5g of polyethylene glycol 1000 in 7.5mL of 0.25M calcium nitrate aqueous solution, stir for several minutes, then add 16mL of ethanol, 4mL of Oleic acid, 0.9mL of 0.25M sodium selenite aqueous solution and 6mL of 0.15M trisodium phosphate solution were stirred evenly at room temperature;

[0025] Step 2: Seal the reaction vessel, react at 90°C for 15 hours, then naturally cool to room temperature, open the reaction vessel, and wash several times with cyclohexane, ethanol and water successively to obtain the final product.

Embodiment 3

[0027] Step 1: In a 40mL polytetrafluoroethylene hydrothermal reaction kettle, dissolve 0.5g of polyethylene glycol 1000 in 7.5mL of 0.25M calcium nitrate aqueous solution, stir for several minutes, then add 16mL of ethanol, 4mL of Oleic acid, 1.35mL of 0.25M sodium selenite aqueous solution and 5.25mL of 0.15M trisodium phosphate solution were stirred evenly at room temperature;

[0028] Step 2: Seal the reactor, react at 150° C. for 5 h, then naturally cool to room temperature, open the reactor, and wash several times with cyclohexane, ethanol and water successively to obtain the final product.

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Abstract

The invention discloses a preparation method of monodispersed selenium doped nano hydroxyapatite. The method is as below: adding soluble calcium salt, soluble phosphate salt and selenite in a mixed system of polyethylene glycol, ethanol and oleic acid; and conducting one-step hydrothermal reaction to obtain selenium-doped nano hydroxyapatite with good dispersion. By controlling the amount of selenate radical, nanorods and nano needles selenium-doped hydroxyapatite can be prepared. The hydroxyapatite nanorod or nanoneedle prepared by the invention can be used for repairing material, coating material and plastic filling material for patient bone defect, and has good application prospect.

Description

technical field [0001] The invention relates to a preparation method of selenium-doped nano-hydroxyapatite with good dispersibility, in particular to a one-step hydrothermal synthesis method of selenium-doped nano-hydroxyapatite nanorods and nanoneedles. Background technique [0002] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) is the main inorganic component in human bones and teeth. Synthetic hydroxyapatite has good bioactivity, biocompatibility and osteoinductivity, and has been widely used as a biomaterial in bone tissue engineering. However, there are still some problems when the synthetic pure hydroxyapatite is applied to hard tissue engineering, such as the prepared ceramic material is brittle, easy to decompose under acidic conditions, and not resistant to high temperature. In order to solve these problems, people are currently doping some ions into hydroxyapatite. Studies have shown that ion-doped hydroxyapatite can greatly improve the physical and chemical propert...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/30A61L27/32A61K47/02C01B25/32B82Y30/00B82Y40/00
CPCA61L27/12A61K47/02A61L27/025A61L27/306A61L27/32A61L2300/102A61L2300/112A61L2420/06A61L2430/02B82Y30/00B82Y40/00C01B25/32C01P2002/72C01P2002/82C01P2004/04C01P2004/16
Inventor 惠俊峰南海珍范代娣郑晓燕米钰李会
Owner NORTHWEST UNIV(CN)
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