Gold-cladded copper selenide nano-particles as well as preparation method and application thereof

A nanoparticle, copper selenide technology, applied in metal processing equipment, wave energy or particle radiation treatment materials, pharmaceutical formulations, etc. Effects of high intensity, photothermal conversion efficiency, and low cytotoxicity

Inactive Publication Date: 2016-11-09
SHANGHAI UNIV OF ENG SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method obtains a composite material with a relatively large size and a length of more than 200nm, which is not conducive to cell phagocytosis, and by first synthesizing gold nanoparticles, and then electrostatically adsorbing them to the modified attapulgite material, there are many steps and the process is complicated

Method used

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  • Gold-cladded copper selenide nano-particles as well as preparation method and application thereof
  • Gold-cladded copper selenide nano-particles as well as preparation method and application thereof
  • Gold-cladded copper selenide nano-particles as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Add anhydrous CuCl (0.099g, 1mmol) into a reaction flask containing 5mL oleylamine and 5mL 1-octadecene mixed solvent, blow nitrogen, heat to 80°C for 1h to remove oxygen and moisture in the system, Stir and heat to 300°C. In another reaction flask, nitrogen gas was passed, and the mixture of 0.039g selenium powder (0.5mmol) and 3mL oleylamine was heated to 150°C for 1h, then heated to 230°C for 1h to completely dissolve the selenium powder, and then the solution was cooled to 100°C Afterwards, it was quickly injected into the reaction bottle containing CuCl, and kept at 300° C. for 15 minutes to react. Rapidly cooled to room temperature, added 5 mL of toluene to the reaction system, added ethanol and washed twice by centrifugation, and finally obtained Cu 2-x Se nanocrystals were dispersed in 10 mL of chloroform.

[0038] (2) 2.5mmol chloroauric acid (HAuCl 4 ·3H 2 O) Dissolved in 10 mL of chloroform and 1 mmol of oleylamine, an additional 10 mL containing 40 m...

Embodiment 2

[0043] (1) Add anhydrous CuCl (0.099g, 1mmol) into a reaction flask containing 5mL oleylamine and 5mL 1-octadecene mixed solvent, blow nitrogen, heat to 80°C for 1h to remove oxygen and moisture in the system, Stir and heat to 280°C. In another reaction flask, nitrogen gas was passed, and the mixture of 0.039g selenium powder (0.5mmol) and 3mL oleylamine was heated to 150°C for 1h, then heated to 230°C for 1h to completely dissolve the selenium powder, and then the solution was cooled to 100°C Afterwards, it was quickly injected into the reaction bottle containing CuCl, and kept at 280° C. for 15 minutes. Rapidly cooled to room temperature, added 5 mL of toluene to the reaction system, added ethanol and washed twice by centrifugation, and finally obtained Cu 2-x Se nanocrystals were dispersed in 10 mL of chloroform.

[0044] (2) 2.5mmol chloroauric acid (HAuCl 4 ·3H 2 O) Dissolve in 8 mL of chloroform and 1 mmol of oleylamine and prepare additionally 12 mL containing 40 mg...

Embodiment 3

[0048] The preparation method of gold-coated copper selenide nanoparticles in this embodiment specifically includes the following steps:

[0049] (1) Add the monovalent copper salt to the organic solvent containing oleylamine and alkene, pass in an inert gas to remove oxygen and water, then stir and heat to 250°C to prepare a mixed reaction solution;

[0050] (2) Mix the selenium powder with oleylamine, pass in an inert gas, heat to 150°C to completely dissolve the selenium powder, then cool to 100°C, inject it into the mixed reaction solution of step (1) quickly, and keep the temperature at 250°C ℃, reacted for 30min, then rapidly cooled to room temperature, and then centrifuged and washed to obtain Cu 2-X Se nanocrystals;

[0051] (3) Cu obtained by step (2) 2-X Se nanocrystals were placed in chloroform containing oleylamine and formulated as Cu 2-X Se nanocrystal solution;

[0052] (4) prepare the chloroform solution of soluble gold salt, and slowly add the chloroform s...

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Abstract

The invention relates to gold-cladded copper selenide nano-particles as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) preparing Cu2-XSe nano-crystals; (2) preparing a chloroauric acid (HAuCl4.3H2O) chloroform solution and a Cu2-XSe nano-crystal solution; (3) dropwise adding the chloroauric acid solution into the Cu2-XSe nano-crystal solution and reacting to obtain Cu2-XSe@Au nano-particles; (4) carrying out surface modification on the Cu2-XSe@Au nano-particles to obtain a Cu2-XSe@Au water solution to obtain the product. The prepared gold-cladded copper selenide nano-particles can be used for preparing a photothermal therapy reagent for treating cancers. Compared with the prior art, the gold-cladded copper selenide nano-particles prepared by the invention have properties of good mechanical strength and thermal stability, high photo-thermal conversion efficiency and biodegradation resistance and the like, are suitable for treating tumors and have a very good application prospect.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and relates to a gold-coated copper selenide nanoparticle and a preparation method and application thereof. Background technique [0002] With the intensification of environmental pollution, changes in diet structure and changes in people's lifestyles, cancer cases are increasing at an alarming rate, and cancer prevention and control is facing very severe challenges. [0003] Existing cancer treatment methods mainly include surgery, chemotherapy and radiotherapy, etc., and these methods have disadvantages. For example, surgery is difficult to remove all cancer cells, often leading to cancer recurrence, and often larger tumors after surgery. The wound caused pain to the patient. However, chemotherapy and radiotherapy cannot identify cancer cells and normal cells, often kill normal cells, and bring greater toxic and side effects to patients. [0004] At present, on the basis of nanom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00B22F9/24B22F1/02
CPCA61K41/0052B22F9/24B22F1/16
Inventor 刘锡建陆杰王烨颖任兰芳邓国英王谦周峰
Owner SHANGHAI UNIV OF ENG SCI
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