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A kind of thermally induced phase separation nanofiber tubular scaffold and preparation method thereof

A technology of thermally induced phase separation and nanofibers, applied in pharmaceutical formulations, prostheses, drug delivery, etc., can solve the problems of small-diameter tubular stents that have not yet appeared, and achieve the effect of promoting rapid growth and rapid endothelialization

Inactive Publication Date: 2019-04-09
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there have been no reports on the preparation of small-diameter tubular scaffolds by combining electrospinning technology, braiding technology and thermal phase separation technology.

Method used

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  • A kind of thermally induced phase separation nanofiber tubular scaffold and preparation method thereof
  • A kind of thermally induced phase separation nanofiber tubular scaffold and preparation method thereof
  • A kind of thermally induced phase separation nanofiber tubular scaffold and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] The preparation mold that embodiment 1 and embodiment 2 adopts is as figure 2 As shown, it includes a mold shaft core 1 for receiving and a mold outer sheath tube 4 sleeved on its outside. The two ends of the mold shaft core 1 are respectively provided with a mold anti-leakage plug 1 2 and a mold anti-leakage plug 2 3 .

[0034] Example 1

[0035] Take 8-month-old healthy porcine thoracic aorta with a caliber of about 3 mm, conduct decellularization treatment, and soak in 0.9% saline for standby; Pure water until all the substrates are submerged, put in -80°C refrigerator for 60 hours, freeze-dry for 60 hours after taking out, and refrigerate at -20°C for later use. Weigh 0.4g PLLA, 0.2gPGS and 0.4gPLCL materials on an analytical balance and mix together, add 10mL tetrahydrofuran solvent, seal the screw-top reaction bottle with a parafilm, place it in a 60°C water bath, and stir it magnetically until the mass / volume fraction is 10% clear homogeneous solution. Subseq...

Embodiment 2

[0037]Take an 8-month-old healthy SD abdominal aorta with a caliber of about 2.2mm, perform decellularization treatment, and soak it in 0.9% normal saline for later use; put the decellularized matrix obtained after treatment in a watch glass, add dropwise Ultrapure water until all the matrix is ​​submerged, put into -80°C refrigerator for 48 hours, take it out and freeze-dry for 48 hours, and refrigerate at -20°C for later use; spin 0.1mm thick nanofibers on the inner diameter of the mold with a stainless steel shaft of 2mm, The nanofibers and the shaft core were put into a vacuum drying oven to dry; the refrigerated decellularized tubular matrix was taken out and placed on the spun nanofiber shaft core as a mechanical reinforcement layer; 0.3g PLLA, 0.1gPGS and 0.6g were weighed on an analytical balance. The g PLCL materials were mixed together, 10 mL of tetrahydrofuran solvent was added, the screw-top reaction bottle was sealed with a parafilm, placed in a 60°C water bath, an...

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Abstract

The invention discloses an acellular dermis matrix enhanced thermally-induced phase separation nanofiber small-bore tubular stent and a preparation method thereof. The preparation method comprises the following steps: performing decellularization treatment on aorta of healthy animals; placing the matrix obtained by decellularization on a watch glass, dropwise adding ultrapure water to submerge all the matrix, and placing in a refrigerator for freezing; spinning nanofibers onto stainless steel shaft core of a mold, putting whole nanofiber and the shaft core into a vacuum drying oven for drying; sheathing the outer layer of the nanofiber with the tubular matrix as a mechanical reinforcing layer; and assembling the compounded double-layer stent together with the shaft core into the mold, and performing solution casting and treatment to obtain the tubular stent. The prepared tubular stent has good mechanical performance, bursting strength and biocompatibility, has no hypersensitivity on a human body in transplanting operation, and has affinity with the blood and peripheral tissues in a human body, thus having good application prospects in cardiovascular and cardiac repair surgeries.

Description

technical field [0001] The invention relates to the technical field of a small-diameter tubular scaffold and its preparation method, in particular to a small-diameter tubular scaffold of acellular matrix-reinforced thermally induced phase separation nanofibers and a preparation method thereof. Background technique [0002] Small-diameter blood vessels (SDVG, D<6mm) are in great demand for clinical use in the treatment of cardiovascular diseases such as coronary artery disease and peripheral vascular disease. The global demand for artificial blood vessels is 1 million pieces per year, and the current actual The dosage is 300,000 per year, and in the United States alone, the average annual number of open angiogenesis operations reaches 250,000 cases per year. However, artificial blood vessels, especially small-diameter blood vessels, not only lack growth activity after transplantation into the human body, but also are not easy to adapt and match with the surrounding environ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/36A61L27/18
CPCA61L27/18A61L27/3625A61L27/3683A61L27/50A61L27/507A61L2400/12A61L2430/40C08L67/00C08L67/04
Inventor 莫秀梅朱同贺于奎沈威谷子琦殷海月潘潇涵陈若昕陈维明郭煦然高强王娟冯文浩吴俣
Owner DONGHUA UNIV
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