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Degradable medical Zn-Li-Fe ternary alloy material, preparation and application

A ternary alloy and alloy material technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of process duplication, slow corrosion rate, increased alloy cost, etc., achieves simple alloy preparation process, improved strength and plasticity, The effect of improving mechanical properties

Inactive Publication Date: 2017-02-08
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the comprehensive mechanical properties of pure zinc are poor, and the corrosion rate is also slow, which is difficult to meet the needs of clinical medicine. Alloying pure zinc is the main method to improve its mechanical properties and corrosion rate. Fe, Li and trace elements Mg, Ca, Sr, Si, Mn and rare earth elements are added to zinc at the same time, but the strength and plasticity of the zinc alloy material prepared by this application are low, and the performance of the ideal material for vascular stents is not yet achieved Require
At the same time, it contains more alloying elements. On the one hand, more types of alloying elements are released during the degradation process, which increases the potential risk to the human body. On the other hand, the duplication of the alloy preparation process increases the difficulty of quality control of the material, and the corresponding alloy cost also increases. up

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  • Degradable medical Zn-Li-Fe ternary alloy material, preparation and application

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Experimental program
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Effect test

Embodiment 1

[0035] This embodiment relates to a degradable medical Zn-Li-Fe alloy material, which includes the following alloy components in weight percentage: Zn: 99.5%, Li: 0.4%, Fe: 0.1%.

[0036] The preparation steps of the alloy material are as follows:

[0037] S1. Weigh each raw material according to the above alloy ratio;

[0038]S2. Put pure zinc (purity ≥ 99.995%) into a crucible with a coating on the inner wall, raise the temperature to 420°C until the pure zinc is completely melted, add pure iron wire when the zinc melt is heated to 600°C, and wait for the pure iron wire to pass through After the corrosion and diffusion reaction with the zinc melt is completely melted, add LiCl and LiF mixed flux (mass ratio: 1:3) at 600°C, and after the above mixed solvent completely covers the surface of the melt, then lower the temperature of the melt to To 550°C, at this time, add pure lithium (purity ≥ 99.999%) under the protection of Ar gas, and after the pure lithium is melted, stir e...

Embodiment 2

[0042] This embodiment relates to a degradable medical Zn-Li-Fe alloy material, which includes the following alloy components in weight percentage: Zn: 95.2%, Li: 4.0%, Fe: 0.8%.

[0043] The preparation steps of the alloy material are as follows:

[0044] S1. Weigh each raw material according to the above alloy ratio;

[0045] S2. Put pure zinc (purity ≥ 99.995%) into an iron crucible with a protective coating on the inner wall, heat up to 420°C and wait for the pure zinc to completely melt, add pure iron wire when the zinc melt is heated up to 610°C, and wait for the pure After the iron wire is completely melted through the corrosion diffusion reaction with the zinc melt, then add LiCl and LiF mixed flux (mass ratio is 1:3) at 610 ° C, and after the above mixed solvent completely covers the surface of the zinc melt, then add the zinc The temperature of the melt drops to 540°C. At this time, pure lithium (purity ≥ 99.999%) is added under the protection of Ar gas, and after t...

Embodiment 3

[0049] This embodiment relates to a degradable medical Zn-Li-Fe alloy material, which includes the following alloy components in weight percentage: Zn: 97.7%, Li: 2.0%, Fe: 0.5%.

[0050] The preparation method of this alloy material is the same as embodiment 1, and difference is:

[0051] S2. Add pure zinc and heat up to 420°C. After the pure zinc is completely melted, add pure iron powder when the melt temperature rises to 580°C. After it is completely melted, add LiCl and LiF at the same temperature (580°C). Mixing flux (mass ratio is 1:3), after the above-mentioned mixed solvent completely covers the surface of the zinc melt, then lower the temperature of the zinc melt to 540°C, at this time, add pure lithium under the protection of Ar gas;

[0052] S3. The refining temperature is 530±10°C, and the amount of hexachloroethane is 0.2% of the total weight of the alloy melt; after refining, stand still at 530±10°C for 30 minutes;

[0053] S4. The homogenization treatment temp...

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Abstract

The invention discloses a degradable medical Zn-Li-Fe ternary alloy material, preparation and application. The material is mainly composed of the following materials: 0.4-4wt.% of Li, 0.1-0.8wt.% of Fe, and 95.2-99.5wt.% of Zn. Before use, the alloy obtained by smelting has to be subjected to thermoplastic deformation machining to refine the alloy structure so as to improve the alloy performance. The zinc alloy provided by the invention has the advantages of excellent comprehensive mechanical properties, good biocompatibility and controllable degradation rate, etc., can be applied as a material for preparing degradable medical implantable devices to preparation of endovascular stents, bone implants, maxillofacial surgery and craniocerebral surgery implantable devices, surgical sutures, various surgical patches, anastomats, vascular clamps or neurorestorative conduits, etc.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a biodegradable medical Zn-Li-Fe ternary alloy material and a preparation method and application thereof. Background technique [0002] At present, the medical materials implanted into the human body are generally made of non-degradable metal materials, such as (1) austenitic stainless steel (316LSS); (2) cobalt-chromium alloy; (3) medical tantalum; (4) titanium and Its alloy; (5) nickel-titanium shape memory alloy; (6) platinum-iridium alloy. The application of these permanent implant materials has the following disadvantages, for example (1) after the permanent metal vascular stent is implanted into the human body, due to its non-degradability, there is a shortcoming of easily forming thrombus to cause restenosis and intimal fibrosis in the stent, and the stent It remains permanently in the body and cannot be taken out again. Once the blood vessel is blocked aga...

Claims

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Application Information

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IPC IPC(8): A61L27/04A61L27/50A61L31/02A61L31/14A61L17/00
CPCA61L17/00A61L27/042A61L27/50A61L31/022A61L31/14A61L2430/02A61L2430/32
Inventor 袁广银岳锐黄华
Owner SHANGHAI JIAO TONG UNIV
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