A kind of production technology of vitamin d3

Abstract

The invention discloses a vitamin D3 production process, which comprises: S1, light irradiation and thermal isomerization reaction; S2, chromatography elution separation; S3, refrigeration crystallization separation; and S4, drying mixing sub-packing. Compared to the process in the prior art, the process of the present invention has the following characteristics that the synthesis process conditions are improved, such that the productivity of the process is improved, and the total yield of the product is more than 90%; the thermal isomerization reaction of the vitamin D3 and the pressure reducing concentration are combined so as to simplify the process steps and save the process energy consumption; the synthesis reaction zone and the purification separation zone are completely separated so as to easily perform process maintenance and process management; in the purification process, the chromatography crystallization method is directly used to replace the original process of chromatography, esterification and hydrolysis crystallization, such that the use of the toxic organic reagent is avoided, and the effects of energy saving, consumption reducing and environmental protection are achieved; and the tail oil tailings generated during the vitamin D3 series production process can be adopted as the feed additive resource so as to be used.

Description

technical field

[0001] The invention relates to the field of fine chemical industry, in particular to a kind of vitamin D conforming to the standard of Pharmacopoeia 3 production process. Background technique

[0002] Vitamin D 3 (Vitamin D 3 ), also known as cholecalciferol, is a colorless crystal with a melting point of 84-85°C. It is a fat-soluble substance, insoluble in water, but soluble in solvents such as alcohol, ether, acetone, chloroform, and vegetable oil. Vitamin D 3 It is easy to oxidize and deactivate in humid air, but it can withstand high temperature and oxidation in neutral and alkaline solutions. Therefore, it should be stored in nitrogen, light-free and acid-free cold environment.

[0003] Vitamins are found in human and most animal tissues. Human skin contains its precursor dehydrocholesterol, which can be transformed into vitamins under sunlight or ultraviolet radiation. Foods such as cod liver oil, liver, roe, butter, milk, and egg yolk are also r...

Images