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Aqueous phase microwave preparation method of CdSeTdS quantum dot-polyacrylamide nanoparticles

The technology of polyacrylamide and nano-microspheres is applied in the field of synthesis of fluorescent nano-materials, which can solve the problems such as that the stability is not improved by an order of magnitude, and achieve the effects of easy control of process parameters, low synthesis cost and high stability.

Active Publication Date: 2017-04-26
WUHAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In order to improve the stability of quantum dots, a layer of CdS and ZnS is often added to the surface to isolate the toxic nucleus and improve the fluorescence stability. Therefore, the aqueous phase synthesis of highly stable near-infrared quantum dots has great application prospects in cell labeling and in vivo imaging.

Method used

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  • Aqueous phase microwave preparation method of CdSeTdS quantum dot-polyacrylamide nanoparticles
  • Aqueous phase microwave preparation method of CdSeTdS quantum dot-polyacrylamide nanoparticles
  • Aqueous phase microwave preparation method of CdSeTdS quantum dot-polyacrylamide nanoparticles

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Embodiment 1

[0031] Below by embodiment, further illustrate outstanding feature of the present invention, only in order to illustrate the present invention and in no way limit the present invention.

[0032] A CdTeSeS quantum dot-polyacrylamide nano-microsphere, which consists of: polyacrylamide (PAL, Mw=15,000, China Shanghai Chemical Reagent Company), selenium powder (Se, Tianjin Kemiou Chemical Reagent Development Center), Sodium tellurite (NaTeO 3 , produced by Aladdin Chemical Reagent Co., Ltd., the mass fraction is 97%), potassium borohydride (KBH 4 , Sinopharm Shanghai Chemical Reagent Co., Ltd., the mass fraction is 96%), cadmium chloride (CdCl 2 2.5H 2 O, Sinopharm Chemical Reagent Co., Ltd.), mercaptopropionic acid (MPA, Japan), and the rest were aqueous solutions.

[0033] In the described CdTeSeS alloy quantum dots, sodium tellurite+sodium selenosulfate, cadmium chloride (CdCl 2 2.5H 2 O), the molar ratio of mercaptopropionic acid (MPA), polyacrylamide is 1:8:20:0.00107, t...

Embodiment 2

[0046] A kind of CdTeSeS alloy quantum dot, it is composed of: polyacrylamide (PAL, Mw=15,000, China Shanghai Chemical Reagent Company), selenium powder (Se, Chemical Reagent Development Center, Kemiou, Tianjin), sodium tellurite (NaTeO 3 , produced by Aladdin Chemical Reagent Co., Ltd., the mass fraction is 97%), potassium borohydride (KBH 4 , Sinopharm Shanghai Chemical Reagent Co., Ltd., the mass fraction is 96%), cadmium chloride (CdCl 2 2.5H 2 O, Sinopharm Chemical Reagent Co., Ltd.), mercaptopropionic acid (MPA, Japan), and the rest were aqueous solutions.

[0047] In the described CdTeSeS alloy quantum dots, sodium tellurite+sodium selenosulfate, cadmium chloride (CdCl 2 2.5H 2 O), the molar ratio of mercaptopropionic acid (MPA), polyacrylamide is 1:8:20:0.00107, the molar ratio of sodium tellurite to sodium selenosulfate is 6:4, and heated at 130°C for 30min.

[0048] The pH of the solution is 8.6-9.2.

[0049] A water-phase microwave preparation method of CdSeTeS...

Embodiment 3

[0058] A water-phase microwave preparation method of CdSeTeS quantum dots-polyacrylamide nano-microspheres, the steps of which are:

[0059] 1. Weigh 2.3670g of selenium powder and 7.5624g of sodium sulfite in a 250mL three-neck flask, add 80mL of deionized water to it, and reflux in a water bath at 90°C for 8 or 9 or 10 hours until the solution is clear and transparent, and the black selenium powder disappears completely. The heat source stops heating. After naturally cooling to room temperature (20-25°C), transfer it to a 100mL volumetric flask and dilute it to the mark with deionized water, which is a 0.30mol / L sodium selenosulfate solution. The reaction equation is as follows:

[0060] Se+Na 2 SO 3 =Na 2 SeSO 3 ;

[0061] 2. Take 200 mL of anaerobic deionized water, add 2.5 mL of 0.10 mol / L cadmium chloride solution and 6 mL of 0.10 mol / L mercaptopropionic acid solution in turn, and adjust the pH value to 9 with 5 mol / L sodium hydroxide solution , add a certain amoun...

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Abstract

The invention discloses an aqueous phase microwave preparation method of CdSeTdS quantum dot-polyacrylamide nanoparticles. The aqueous phase microwave preparation method comprises the following steps: A, enabling selenium powder and sodium sulfite to react, and preparing a selenium-substituted sodium sulfate solution; B, weighing cadmium chloride crystal, dissolving deionized water, and performing volume fixation to obtain a cadmium chloride solution; C, adding thiohydracrylic acid into the cadmium chloride solution; D, adjusting the pH value by using a sodium hydroxide solution; E, adding sodium tellurate crystal, and adding potassium borohydride and the selenium-substituted sodium sulfate solution after the sodium tellurate crystal is dissolved and stabilized; F, injecting a CdSeTeS precursor solution into a bottle, injecting a polyacrylamide solution, and stirring to obtain quantum dots; G, injecting a precursor solution into a microwave reactor, and heating so as to obtain polyacrylamide nanoparticles; H, cooling, adding isopropanol, purifying, and performing freeze-drying, thereby obtaining a colloidal solid of the CdSeTdS quantum dot-polyacrylamide nanoparticles. The aqueous phase microwave preparation method is simple in process, easy to control and low in price, the light stability of a synthesized product is 20 times higher than that of a single CdTeSeS quantum dot, and the biological stability of the synthesized product is improved by 15%.

Description

technical field [0001] The invention relates to the synthesis of fluorescent nanometer materials, more specifically to a water-phase microwave preparation method of CdSeTeS quantum dots-polyacrylamide nanometer microspheres, and is especially suitable for biological fluorescent labeling materials, especially cell labeling and clinical diagnosis and application. Background technique [0002] At present, among the problems about near-infrared quantum dots, the most urgent to be solved is their toxicity. Commonly used near-infrared quantum dots contain heavy metal ions, which will be released more or less during the biological application process, and it is difficult to evaluate their toxicity and safety. Therefore, changing the synthesis method of traditional quantum dots and preparing low-toxic or non-toxic quantum dots has become a challenge for biological applications. In order to improve the stability of quantum dots, a layer of CdS and ZnS is often added to the surface t...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/88B01J13/04
CPCB01J13/04B01J2219/00141C09K11/025C09K11/883
Inventor 周培疆刘西京詹红菊
Owner WUHAN UNIV
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