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CS (calcium silicate)/PEEK (poly(ether-ether-ketone)) composite bone repair material, bone repair body as well as preparation method and application of material

A polyetheretherketone and bone prosthesis technology, applied in the field of medical biomaterials, can solve the problems of poor osteogenic performance, easy falling off of the coating, loosening of the PEEK implant, etc., and achieve the effect of improving the bonding speed and strength

Inactive Publication Date: 2017-05-10
汤亭亭 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PEEK is a biologically inert material with poor osteogenic performance and cannot form bony fusion; after PEEK implantation, a fibrous boundary membrane is easily formed between the PEEK material and the tissue, resulting in loosening or even prolapse of the PEEK implant.
[0004] At present, the surface activity of PEEK materials is generally improved by spraying titanium and hydroxyapatite (HA) on its surface, but the coating is easy to fall off and cause inflammation in the surrounding tissues

Method used

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  • CS (calcium silicate)/PEEK (poly(ether-ether-ketone)) composite bone repair material, bone repair body as well as preparation method and application of material
  • CS (calcium silicate)/PEEK (poly(ether-ether-ketone)) composite bone repair material, bone repair body as well as preparation method and application of material
  • CS (calcium silicate)/PEEK (poly(ether-ether-ketone)) composite bone repair material, bone repair body as well as preparation method and application of material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] A calcium silicate / polyetheretherketone composite bone repair material is made by mixing 45% calcium silicate and 55% polyetheretherketone. The ketone is in powder form (particle size is 30 μm).

[0071] The preparation method of the calcium silicate / polyetheretherketone composite material comprises the following steps:

[0072] Mix 4.5kg calcium silicate powder (particle size is 20μm) and 5.5kg polyetheretherketone powder (particle size is 30μm) in a mixer to obtain mixed powder; then mix powder with twin-screw extruder at high temperature After melt blending, extrusion and granulation are performed, and the temperature of the melt extrusion is 370°C to 380°C; the pressure of the twin-screw extruder is 80 MPa to 100 MPa.

Embodiment 2

[0074]A calcium silicate / polyetheretherketone composite bone repair material is made of 45% calcium silicate and 55% polyetheretherketone, the calcium silicate is powder (with a particle size of 20 μm), and the polyetheretherketone is Powder (particle size of 30 μm), calcium silicate powder was pretreated with an ethanolic solution of polyethylene glycol 4000.

[0075] The preparation method of the calcium silicate / polyetheretherketone composite material comprises the following steps:

[0076] 4.5kg of calcium silicate powder (particle size is 20 μm) is treated with an ethanol solution of polyethylene glycol 4000, and the amount of polyethylene glycol 4000 is 1% to 4% of the amount of calcium silicate. Dry in the oven. 5.5 kg of polyether ether ketone powder (with a particle size of 30 μm) was washed three times with an ethanol solution, and the washed PEEK powder was dried in an oven. The treated calcium silicate and PEEK powder are uniformly mixed in a mixer to obtain a mi...

Embodiment 3

[0078] A calcium silicate / polyetheretherketone composite bone repair material is made of 50% calcium silicate and 50% polyetheretherketone, the calcium silicate is powder (with a particle size of 30 μm), and the polyetheretherketone is Powder (40 μm particle size), calcium silicate powder was pretreated with an aqueous solution of sodium carboxymethylcellulose.

[0079] The preparation method of the calcium silicate / polyetheretherketone composite material comprises the following steps:

[0080] 5kg of calcium silicate powder (with a particle size of 30 μm) is treated with an aqueous solution of sodium carboxymethyl cellulose, and the amount of sodium carboxymethyl cellulose is 2% to 3% of the amount of calcium silicate. Dry in the oven. 5 kg of polyether ether ketone powder (40 μm in particle size) was washed three times with ethanol solution, and the washed PEEK powder was dried in an oven. The treated calcium silicate and PEEK powder are uniformly mixed in a mixer to obtai...

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Abstract

The invention discloses a CS (calcium silicate) / PEEK (poly(ether-ether-ketone)) composite bone repair material, a bone repair body as well as a preparation method and an application of the material. In the CS / PEEK composite bone repair material, CS accounts for 30%-50% and PEEK accounts for 50%-70%; the particle size of CS is 20-30 mu m, and the particle size of PEEK is 30-40 mum. The CS / PEEK composite bone repair material has excellent mechanical properties, has the elasticity modulus similar to that of natural bone, has better osteogenesis bioactivity, has excellent mechanical compatibility, cannot cause bone resorption due to stress shielding, can promote regeneration of peripheral bone tissue and fusion with natural bone tissue after being implanted into a human body and can meet requirements of immediate fixation and long-term stability of postoperative orthopedic instruments.

Description

technical field [0001] The invention relates to the field of medical biological materials, in particular to a calcium silicate / polyetheretherketone composite bone repair material, a bone repair body and a preparation method and application thereof. Background technique [0002] With the development of my country's industrial transportation and the aging of the population, the incidence of diseases such as severe bone trauma and bone degeneration has gradually increased, which has put forward new requirements for the development of orthopedic medical devices, that is, it needs to have good biological activity, implantation After the body can form osseous union. However, the currently widely used orthopaedic fixation materials and bone defect repair materials all have the problem of poor biological activity. [0003] At present, titanium alloys and polyetheretherketone (PEEK) orthopaedic fixation or repair materials are widely used in clinical practice. However, the elastic m...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/54A61L27/56A61L31/12A61L31/14A61L31/16A61L27/30A61L31/08
CPCA61L27/306A61L27/446A61L27/54A61L27/56A61L31/088A61L31/128A61L31/146A61L31/16A61L2300/102A61L2300/412A61L2420/02A61L2430/02C08L61/16
Inventor 汤亭亭魏杰
Owner 汤亭亭
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