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Method for detecting content of sodium, potassium and chloride ions in polyethylene glycol electrolyte preparation

A technology of chloride ion content and determination method, which is applied in the direction of measuring devices, material separation, instruments, etc., can solve problems such as errors in titration end point judgment, different anion and cation determination methods, and risks of preparation quality control, and achieve deviations in test results Small size, high sample detection efficiency, and the effect of saving detection time

Inactive Publication Date: 2017-05-10
STAIDSON BEIJING BIOPHARMACEUTICALS CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Flame photometry and atomic absorption spectrophotometry are less stable, and there are errors in the judgment of the end point of the titration method. The above methods may cause deviations in the results of ion content, which in turn may cause risks in the quality control of preparations; Complicated and cumbersome operation

Method used

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  • Method for detecting content of sodium, potassium and chloride ions in polyethylene glycol electrolyte preparation
  • Method for detecting content of sodium, potassium and chloride ions in polyethylene glycol electrolyte preparation
  • Method for detecting content of sodium, potassium and chloride ions in polyethylene glycol electrolyte preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: external standard method measures sodium, potassium, chloride ion content in polyethylene glycol electrolyte powder

[0045] 1. Chromatographic conditions:

[0046] Instrument: Wantong 940 ion chromatograph;

[0047] Chromatographic column: ion exchange column, cation column 4.6×150mm, anion column 4.6×100mm;

[0048] Detector: conductivity detector;

[0049] Eluent: cationic 2.5mM nitric acid aqueous solution, anionic 3.5mM sodium carbonate and 1.0mM sodium bicarbonate aqueous solution

[0050] Flow rate: cation 1.0ml / min, anion 0.7ml / min;

[0051] Column temperature: 40°C;

[0052] Injection volume: 20 μl.

[0053] 2. Experimental steps:

[0054] 1. Determination of control and other maps

[0055]Take standard solutions of sodium, potassium, and chloride ions (purchased from China Institute of Metrology) with known contents respectively, and prepare solutions containing sodium 10 μg / ml, potassium 1.25 μg / ml, and chlorine 12.5 μg / ml with water as t...

Embodiment 2

[0082] Embodiment 2: external standard method measures sodium, potassium, chloride ion content in polyethylene glycol electrolyte oral liquid

[0083] 1. Chromatographic conditions:

[0084] Instrument: Wantong 940 ion chromatograph;

[0085] Chromatographic column: ion exchange column, cation column 4.6×150mm, anion column 4.6×100mm;

[0086] Detector: conductivity detector;

[0087] Eluent: cationic 2.3mM nitric acid aqueous solution, anionic 3.2mM sodium carbonate and 1.1mM sodium bicarbonate aqueous solution

[0088] Flow rate: cation 1.2ml / min, anion 0.8ml / min;

[0089] Column temperature: 35°C; injection volume: 20 μl.

[0090] 2. Experimental steps:

[0091] 1. Determination of control spectrum

[0092] The experimental procedure is the same as in Example 1. Anion and cation eluents have no interference to the detection of each ion content, polyethylene glycol electrolyte oral liquid excipients (i.e. polyethylene glycol, acesulfame potassium, sucralose, methylpar...

Embodiment 3

[0111] Embodiment 3: external standard method measures sodium, potassium, chloride ion content in polyethylene glycol electrolyte oral liquid

[0112] 1. Chromatographic conditions:

[0113] Instrument: Wantong 940 ion chromatograph;

[0114] Chromatographic column: ion exchange column, cation column 4.6×150mm, anion column 4.6×100mm;

[0115] Detector: conductivity detector;

[0116] Eluent: cationic 2.7mM nitric acid aqueous solution, anionic 3.8mM sodium carbonate and 0.9mM sodium bicarbonate aqueous solution

[0117] Flow rate: cation 0.8ml / min, anion 0.6ml / min;

[0118] Column temperature: 45°C;

[0119] Injection volume: 20 μl.

[0120] 2. Experimental steps:

[0121]Experimental procedure is with embodiment 2, detects the chromatogram that obtains according to above-mentioned detection condition, as Figure 13 . The measured sodium, potassium, and chloride ion content results are shown in Table 8, and the inspection results such as symmetry factors are shown in ...

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Abstract

The invention belongs to the field of medicine, and particularly provides a method for detecting the content of sodium, potassium and chloride ions in a polyethylene glycol electrolyte preparation by using a high performance liquid chromatography method. According to the specific chromatographic condition, the leacheate of cation sodium and potassium is an aqueous solution of 2.3-2.7mM nitric acid, having a flowing speed of 0.8-1.2ml / min; and the leacheate of anion chloride is an aqueous solution of 3.2-3.8mM sodium carbonate and 0.9-1.1mM sodium bicarbonate, having a flow speed of 0.6-0.8ml / min; the chromatographic column is an ion-exchange chromatographic column; and the detector is an electrical conductivity detector. The detecting method has the advantages of strong specificity, simple and quick operation, high sensitivity, relatively good repeatability, relatively good precision and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a method for determining the content of sodium, potassium and chloride ions in polyethylene glycol electrolyte preparations. Background technique [0002] Polyethylene Glycol (PEG) is a high molecular polymer obtained by polymerization of ethylene oxide. It has the effect of laxative and bowel cleansing clinically. The specific mechanism of action is: after polyethylene glycol enters the body through oral administration, it binds and fixes the inherent water molecules in the intestinal cavity through hydrogen bonds, increases the water content of the feces, increases the volume and weight of the feces, softens the feces, and promotes the stool in the intestinal cavity. It can improve constipation, restore stool volume and weight to normal, and promote the final completion of defecation, thereby improving constipation symptoms; at the same time, because its laxative and bowel ...

Claims

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Application Information

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IPC IPC(8): G01N30/96
CPCG01N30/96
Inventor 张帆冯彩丽
Owner STAIDSON BEIJING BIOPHARMACEUTICALS CO LTD
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