Preparation method for guided tissue regeneration membrane for periodontitis repair

A technology for guiding tissue regeneration and periodontitis, applied in the field of preparation of guiding tissue regeneration membrane, can solve the problems of restricting the use of regeneration membrane, unfavorable bone repair, matching the degradation speed of bone tissue repair speed, etc. Responsiveness, enhanced adhesion and proliferation, improved biocompatibility
CN106798950AInactive Publication Date: 2017-06-06ZHEJIANG UNIV OF TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2017-06-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method for a guided tissue regeneration membrane for periodontitis repair, wherein the preparation method comprises the following steps: (1) adding serine, lactic acid and a catalyst stannous isocaprylate to a reaction vessel, under a vacuum reduced pressure condition, carrying out a reaction at the temperature of 150 DEG C until no water is steamed out, to prepare a low-molecular-weight PLAS; (2) adding lactide, glycolide and serine in the reaction vessel, under the action of an initiator stannous isocaprylate, carrying out a reaction for 3 hours in vacuum oil bath at the temperature of 150 DEG C, to obtain a high-molecular-weight PLGAS; and (3) mixing evenly the PLAS and the PLGAS, crushing, adding a solvent, stirring until the components are completely dissolved, to obtain a solution A, and brushing to form a membrane by a membrane coating device. The guided tissue regeneration membrane prepared by the method has the advantages of good biocompatibility, basically consistent degradation speed and bone tissue repair, little interference on bone repair, difficult appearing of delayed tissue response, and excellent physical properties, and can be applied in skeleton pads for periodontitis repair.
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Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to a preparation method of a guided tissue regeneration film used for periodontitis repair. Background technique

[0002] Periodontitis is an oral disease caused by related microorganisms. Its main clinical manifestations include swelling and bleeding of the gums, formation of periodontal pockets, resorption of root bone, and loose teeth. In addition, some systemic diseases such as cardiovascular disease and diabetes are also closely related to periodontitis. Periodontitis often leads to the loss of surrounding bone tissue and loose teeth. Traditional periodontal treatment often cannot effectively improve the food impaction and aesthetic problems caused by periodontal bone defect. Therefore, how to repair the defective periodontal bone tissue and reduce the Tooth loss has become a hot spot in periodontal disease treatment. The guided bone regeneration (GBR) technology that has...

Claims

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