Green method for preparation of aldehyde or ketone by iron catalyzed alcohol oxidation

Abstract

The invention provides a green method for preparation of aldehyde or ketone by iron catalyzed alcohol oxidation. The method adopts a common iron salt as the catalyst, uses an oxynitride as the cocatalyst, can realize oxidation of various alcohols in a non-halogen solvent and under open air room temperature conditions, and especially can achieve oxidation of high selectivity non-active fatty primary alcohol. The catalytic system uses a cheap and easily available, non-toxic and high activity iron catalyst system, and uses economical, safe and green air as the oxidant. The reaction temperature can be set at room temperature condition. The catalytic system has few components, and additional adding of a ligand or alkali compound is unnecessary. The reaction is easy in operation, and especially can realize oxidation of non-active fatty primary alcohol into aldehyde or ketone efficiently. The method provided by the invention has very mild requirements for reaction conditions, and has good research and industrial application prospects.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, and in particular relates to an iron catalyst, a green method for oxidizing alcohols into aldehydes or ketones at room temperature by using air as an oxygen source. Background technique [0002] The selective oxidation of alcohols to corresponding aldehydes or ketones is a very important functional group conversion reaction in organic synthesis, which is of great significance for both basic research and industrial large-scale production. Aldehydes and ketones are important industrial raw materials, spices and synthetic drug intermediates. The annual production of carbonyl compounds in the world exceeds one million tons, and most of these compounds are produced by oxidation of alcohols. The traditional method of alcohol oxidation is stoichiometric. Commonly used oxidants are chromium reagents, manganese reagents, oxides of ruthenium, activated dimethyl sulfoxide, hypervalent iodide, etc. These ...

AI Technical Summary

Problems solved by technology

However, many methods still require the use of noble metal catalysts, highly dangerous pure oxygen as the oxidant, and the use of highly toxic halogen solvents, so the application potential is limited

Moreover, many catalysts only have superior catalytic performance for relatively active fatty secondary alcohols, benzyl alcohol and allyl alcohol, but have very low activity for fatty primary alcohols.

At present, there are few methods that can use cheap, non-toxic, room temperature, and open catalytic systems to achieve alcohol oxidation, and some methods require additives, ligands, etc., which affect their application.

Images