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Preparation method and application of chitosan-silicon dioxide nanoparticle hybrid material

A nano-hybrid material, silicon dioxide technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of low mechanical strength, limitation, mismatch of mechanical properties of bone, etc., and achieve good mechanical properties and biological activity. High and good toughness

Active Publication Date: 2017-07-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are many research reports on the application of chitosan in absorbing implant materials, but these studies mainly focus on one-dimensional wires (such as surgical sutures) or two-dimensional films (such as artificial skin). Injected materials are mostly used in hydrogels. These wires, films and hydrogels have low mechanical strength and do not match the mechanical properties of bone. Therefore, the application of pure chitosan as a material is limited.

Method used

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  • Preparation method and application of chitosan-silicon dioxide nanoparticle hybrid material
  • Preparation method and application of chitosan-silicon dioxide nanoparticle hybrid material

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Weigh 7g of chitosan powder (degree of deacetylation 75%, viscosity average molecular weight 200,000) and dissolve in 93g of 3.5% (v / v) dilute acetic acid aqueous solution to prepare a chitosan solution for subsequent use. Weigh 5.39g of γ-(2,3-glycidoxy)propyltrimethoxysilane and add it into the chitosan solution, and stir and react in a water bath at 23°C for 120h. Weigh 19.8g tetraethyl orthosilicate and add it to 16.8mL 5mol / L acetic acid solution, stir for 4h to make it hydrolyzed, add 100g chitosan-silane coupling agent solution to the hydrolyzate, stir evenly, vacuum defoam, mix The solution was poured into the mold and allowed to stand for 48 hours to form a gel. The gel in the mold was taken out, put into a constant temperature and humidity box with a temperature of 15° C. and a relative humidity of 30% for curing for 7 days, and a transparent and dense solid was obtained. Immerse the solid in 500 mL of 5 mol / L tris aqueous solution, take it out after 24 hours...

Embodiment 2

[0030] Weigh 3g of chitosan powder (deacetylation degree 100%, viscosity average molecular weight 1,000,000) and dissolve in 97g of 1.5% (v / v) lactic acid aqueous solution to prepare chitosan solution for subsequent use. Weigh 1.20 g of γ-isocyanate propyltrimethoxysilane and add it into the chitosan solution, and stir and react in a water bath at 23° C. for 1 h. Weigh 12.1g tetraethyl orthosilicate and add it to 16.8mL 1mol / L lactic acid solution and stir for 4 hours to make it hydrolyzed, add 100g chitosan-silane coupling agent solution to the hydrolyzed solution, stir evenly, vacuum defoaming, The mixture was poured into the mold and left to stand for 48 hours to form a gel. The gel in the mold was taken out, and put into a constant temperature and humidity box with a temperature of 40° C. and a relative humidity of 80% for curing for 28 days to obtain a transparent and dense solid. Immerse the solid in 500mL of 0.1mol / L sodium hydroxide aqueous solution, take it out after...

Embodiment 3

[0032] Weigh 10g of chitosan powder (degree of deacetylation 90%, viscosity average molecular weight 470,000) and dissolve in 90g of 5% (v / v) glycolic acid aqueous solution to prepare a chitosan solution for subsequent use. Weigh 26.4g ethyl orthosilicate and add it into 1mol / L glycolic acid solution and stir for 4h to make it hydrolyze. Add 100 g of chitosan solution with a mass fraction of 10% into the solution, stir evenly, vacuum defoam, inject the mixed solution into a mold, and let it stand for 48 hours to form a gel. The gel in the mold was taken out, and placed in a constant temperature and humidity chamber with a temperature of 23°C and a relative humidity of 50% for 3 days to obtain a transparent and dense solid. Immerse the solid in 500mL of 1mol / L aqueous solution of trishydroxymethylaminomethane, take it out after 24h, soak it in ultrapure water until it becomes neutral, and dry it in an oven at 30°C. The compressive strength, compressive modulus and compressive ...

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Abstract

The invention discloses a preparation method and application of a chitosan-silicon dioxide nanoparticle hybrid material. The preparation method comprises the following preparation steps that chitosan and a silane coupling agent react in an acid solution, and the chitosan and the silane coupling agent produce a covalent bond bound intermediate solution; tetraethoxysilane is hydrolyzed in the acid solution to generate a silicon dioxide precursor solution, the silicon dioxide precursor solution is mixed with the chitosan-silane coupling agent intermediate solution, even stirring is performed, then vacuum bubble removal is performed, the mixed solution is poured into a mold, standing is performed for a period of time to generate gel, the gel is dried and cured to obtain the hybrid material, the hybrid material is treated with an alkali solution to remove acid contained in the material, then the solution is washed with pure water to reach neutral, and the chitosan-silicon dioxide nanoparticle hybrid material is prepared after drying. The chitosan-silicon dioxide nanoparticle hybrid material has the advantages of high strength and good toughness, preparation technology is simple and easy to operate, the raw materials are wide in source, and the material haa mechanical properties and high biological activity and has the wide application prospect in the field of regenerative medicine and bone repair.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a preparation method and application of a high-strength chitosan-silicon dioxide nanometer hybrid material. Background technique [0002] Regenerative medicine and tissue engineering are effective methods for treating tissue trauma and defects. The key is to develop scaffold materials with excellent mechanical properties and biocompatibility. In particular, bone tissue engineering puts forward higher requirements for the mechanical properties and toughness of scaffold materials. Require. However, existing materials including bioactive glasses, bioceramics, polymers, and conventional composites do not meet all requirements for bone repair materials. In recent years, organic-inorganic hybrid materials have attracted the interest of researchers due to their potential to generate high-performance materials. Hybrid materials are a special kind of organic-inorganic composite mater...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/02A61L27/50A61L27/58
CPCA61L27/025A61L27/20A61L27/50A61L27/58A61L2430/02C08L5/08
Inventor 赵娜如梁锦宁董怡帆吴刚
Owner SOUTH CHINA UNIV OF TECH
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