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Compound bone cement with high inorganic components as well as preparation method and application of compound bone cement

An inorganic component and composite technology, applied in the field of medical materials, can solve the problems of slow degradation rate of nano-hydroxyapatite, loosening between implant materials and host bone, and inflammatory response of surrounding tissues, and achieve a simple and feasible preparation method, Effect of enhancing biocompatibility and enhancing absorbability

Active Publication Date: 2017-08-15
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there are also the following disadvantages: First, a large amount of heat is released during the self-coagulation process, which can easily cause inflammation in the surrounding tissues, resulting in loosening between the implant material and the host bone.
However, in later experiments in animals, it was found that the above-mentioned bone cement materials are very stable in animals, and new bone only exists around the PMMA bone cement, which means that the degradation rate of modified nano-hydroxyapatite is slower
[0004] Therefore, there is an urgent need for a solution to the problem that the above-mentioned degradation and absorption only occur on the surface of the bone cement, and the absorption rate is slow, so as to better meet the needs of clinical bone cement materials.

Method used

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  • Compound bone cement with high inorganic components as well as preparation method and application of compound bone cement
  • Compound bone cement with high inorganic components as well as preparation method and application of compound bone cement
  • Compound bone cement with high inorganic components as well as preparation method and application of compound bone cement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: raw material preparation:

[0034] 1. Synthesis of PMMA:

[0035] Dissolve 0.35g polyvinyl alcohol (PVA), 56ml MMA and 0.13g benzoyl peroxide (BPO) in 360ml deionized water, stir vigorously, raise the temperature to 80°C for 2 hours, then raise the temperature to 87°C for 2 hours , and finally raised the temperature to 95° C. for 2 hours to obtain a white granular product, which was washed twice with water and twice with alcohol, and then dried in vacuum. After the product is completely dry, use a ball mill to grind it, pass through a 100-mesh sieve to obtain white PMMA powder, and store it dry.

[0036] 2. Synthesis of P(MMA-co-MPS):

[0037] 2.1 Raw material purification

[0038] THF purification: Add calcium hydride to tetrahydrofuran (THF) and heat to 62°C for distillation. Add sodium potassium alloy to the liquid obtained after distillation and heat it to 62°C for distillation to obtain anhydrous THF with high purity.

[0039] MPS purification: A...

Embodiment 2

[0052] Example 2: Synthesis of Bone Cement:

[0053] At room temperature, the solid components and liquid components of bone cement were mixed in a ratio of 1:3 by mass to volume (W / V), stirred evenly, poured into the mold, and the samples were taken out after complete curing.

[0054] The solid phase components include PMMA, 0.3-nHA, β-TCP, BaSO 4 , BPO; liquid components include MMA, DMT. Among them, the molecular weight of PMMA is about 750,000. The raw material ratio of embodiment 2~4 is shown in table 1:

[0055] Table 1

[0056]

Embodiment 3

[0057] Example 3: Mechanical Properties Test

[0058] The mechanical property characterization of bone cement in Example 2 mainly chooses to test the compressive property of the finished product. The test method is as follows: the compression test bone cement sample is ground into a cylinder with a length of 12 mm and a diameter of 6 mm. Use a universal material testing machine (WD-5A) with a loading rate of 5 mm / min. Record the stress-deformation diagram of the sample, take the stress when the K value in the stress-deformation curve is 2%, and divide it by the cross-sectional area of ​​the cylinder to obtain the compressive strength.

[0059] All mechanical property tests are carried out according to ISO 5833 international standard.

[0060] The mechanical properties of the CaP / HA-PMMA bone cement in the present invention are characterized by compressive strength. from figure 2 It can be seen that the compressive strength of CaP / HA-PMMA bone cement is increased compared ...

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Abstract

The invention discloses compound bone cement with high inorganic components. The compound bone cement contains a solid-phase component and a liquid-phase component, wherein the solid-phase component contains P(MMA-co-MPS) surface-modified hydroxyapatite, polymethyl methacrylate, beta-tricalcium phosphate and benzoyl peroxide, and the liquid-phase component contains methyl methacrylate and dimethyl terephthalate; the mass volume ratio of the solid-phase component to the liquid-phase component of the compound bone cement is 1 to (2.5-3.5); and the sum of P(MMA-co-MPS) surface-modified hydroxyapatite and methyl methacrylate is 35%-40% of weight of the solid-phase component. According to the compound bone cement, tricalcium phosphate (beta-TCP) and P(MMA-co-MPS) surface-modified hydroxyapatite are compounded, and meanwhile, the proper modification degree of p(MMA-co-MPS) to hydroxyapatite is adjusted, so that the mechanical performance of the raw materials is guaranteed, meanwhile, the biological activity of the material is increased, and the degradation speed of the material is proper; and therefore, the compound bone cement has excellent mechanical properties and biological properties.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and more specifically relates to a composite bone cement with high inorganic components and its preparation method and application. Background technique [0002] Polymethylmethacrylate (PMMA) bone cement is widely used in hip replacement and other surgeries because of its good biomechanical properties and rapid prototyping. However, there are also the following disadvantages: First, a large amount of heat is released during the self-aggregation process, which easily causes inflammation in the surrounding tissue, resulting in loosening between the implant material and the host bone. Second, PMMA is an inert material and has no biological activity. Third, it is difficult to degrade. [0003] In view of the above shortcomings, the applicant has previously explored the mechanical properties and biological properties of the bone cement mixed with p(MMA-co-MPS) modified nano-hydroxyapatite ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/56
CPCA61L27/46A61L27/56A61L2300/604
Inventor 全昌云蒋庆康婷张夏诗瑶王季平
Owner SUN YAT SEN UNIV
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