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Levofloxacin lactate dispersible tablet and preparation method thereof

A technology of levofloxacin lactate and levofloxacin, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve the problems of poor action of anaerobic bacteria and enterococci, poor dispersion uniformity, and effective drug efficiency Low-level problems, to achieve excellent dispersion uniformity, fast dispersion speed, and improve the effect of drying and molding

Inactive Publication Date: 2017-09-08
HAINAN JINXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It also has antibacterial effects on Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes, as well as Mycoplasma pneumoniae and Chlamydia pneumoniae, but its effect on anaerobic bacteria and enterococci is poor
However, the existing levofloxacin lactic acid dispersible tablets often have the problems of high levels of related substances and deviations in dispersion uniformity, resulting in poor drug efficacy and low drug efficiency.

Method used

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  • Levofloxacin lactate dispersible tablet and preparation method thereof
  • Levofloxacin lactate dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A levofloxacin lactate dispersible tablet, comprising the following raw materials by weight: 100 parts of levofloxacin lactate, 48 parts of microcrystalline cellulose, 34 parts of sodium starch glycolate, 38 parts of starch, 4 parts of micropowder silica gel and 4 parts of magnesium stearate;

[0024] Among them, levofloxacin lactate is the main drug, microcrystalline cellulose is the filler and disintegrating agent, carboxymethyl starch sodium is the disintegrating agent, starch is the filler, and micronized silica gel and magnesium stearate are lubricants.

Embodiment 2

[0026] A levofloxacin lactate dispersible tablet, comprising the following raw materials by weight: 100 parts of levofloxacin lactate, 52 parts of microcrystalline cellulose, 36 parts of sodium starch glycolate, 42 parts of starch, 6 parts of micronized silica gel and 6 parts of magnesium stearate;

[0027] Among them, levofloxacin lactate is the main drug, microcrystalline cellulose is the filler and disintegrating agent, carboxymethyl starch sodium is the disintegrating agent, starch is the filler, and micronized silica gel and magnesium stearate are lubricants.

Embodiment 3

[0029] A levofloxacin lactate dispersible tablet, comprising the following raw materials by weight: 100 parts of levofloxacin lactate, 50 parts of microcrystalline cellulose, 35 parts of sodium starch glycolate, 40 parts of starch, 5 parts of micropowder silica gel and 5 parts of magnesium stearate;

[0030] Among them, levofloxacin lactate is the main drug, microcrystalline cellulose is the filler and disintegrating agent, carboxymethyl starch sodium is the disintegrating agent, starch is the filler, and micronized silica gel and magnesium stearate are lubricants.

[0031] The preparation method of the levofloxacin lactate dispersible tablet of above-mentioned embodiment 1~3, comprises the following steps:

[0032] (1) Pulverizing and sieving: get levofloxacin lactate to pulverize, get pulverized levofloxacin lactate and starch, microcrystalline fiber, sodium starch glycolate and directly pass through a 110 mesh sieve;

[0033] (2) Premixing: Mix the microcrystalline cellulos...

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Abstract

The invention discloses a levofloxacin lactate dispersible tablet and a preparation method thereof. The levofloxacin lactate dispersible tablet comprises the following raw materials in parts by weight: 100 parts of levofloxacin lactate, 48-52 parts of microcrystalline cellulose, and 34-36 parts of carboxymethyl starch sodium , 38-42 parts of starch, 4-6 parts of micropowder silica gel and 4-6 parts of magnesium stearate; among them, levofloxacin lactate is the main drug, microcrystalline cellulose is the filler and disintegrating agent, and sodium carboxymethyl starch is the disintegrating agent. agent, starch as filler, micronized silica gel and magnesium stearate as lubricant. The levofloxacin lactate dispersible tablet prepared by the invention has low related substances, good dispersion uniformity and fast dispersion speed, can better exert the drug effect of the levofloxacin lactate, improve the drug efficacy, improve the stability of the drug, and reduce the toxic and side effects of the drug.

Description

technical field [0001] The invention relates to the technical field of levofloxacin, in particular to a levofloxacin lactate dispersible tablet and a preparation method thereof. Background technique [0002] Levofloxacin is one of the quinolones. It has broad-spectrum antibacterial effect and strong antibacterial effect. It is effective against most Enterobacteriaceae bacteria, such as E. Gram-negative bacteria such as Haemophilus influenzae, Legionella pneumophila, and Neisseria gonorrhoeae have strong antibacterial activity. It also has antibacterial effects on Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes, as well as Mycoplasma pneumoniae and Chlamydia pneumoniae, but its effect on anaerobic bacteria and enterococci is poor. However, the existing levofloxacin lactic acid dispersible tablets often have the problems of high levels of related substances and deviations in dispersion uniformity, resulting in poor dr...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/12A61K47/02A61K31/5383A61P31/04
CPCA61K9/2095A61K9/2009A61K9/2013A61K9/2054A61K9/2059A61K31/5383
Inventor 张丽杰刘全胜
Owner HAINAN JINXING PHARMA
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