Preparation method of nano-pearl powder/C-HA composite scaffold

A technology of nano pearl powder and composite scaffold, which is applied in the field of bioengineering, can solve the problems that hydroxyapatite is not easy to degrade, and the degradation speed of tricalcium phosphate cannot be regulated, and achieves the advantages of proliferation, good biological activity and good wettability. Effect
CN107185048AActive Publication Date: 2017-09-22海口市人民医院
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
海口市人民医院
Publication Date
2017-09-22

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Abstract

The invention discloses a preparation method of nano-pearl powder / C-HA composite scaffold. The preparation method comprises the following steps: firstly, dissolving chitosan and hyaluronic acid into an acetic acid solution with concentration of 1% respectively, stirring at 2000rpm for 5min, placing at room temperature for 24 hours, and obtaining a chitosan acetic acid solution and a hyaluronic acid acetic acid solution; secondly, 24 hours later, mixing the chitosan acetic acid solution and the hyaluronic acid acetic acid solution, and stirring at 2000rpm for 5 min; thirdly, adding the nano-pearl powder with the weight percentage of 1 to 25%, stirring at 2000 rpm for 5min; fourthly, putting into a -20 DEG C refrigerator for 24h, then freeze drying for 24h, and obtaining the composite scaffold. The technical problem to be solved by the invention is to provide a preparation method of nano-pearl powder / C-HA composite scaffold which has a suitable pore structure, is advantageous for cell proliferation, blood vessel growth and transport of nutrients, has good biological activity, biocompatibility and biodegradability, and can adapt to the specific shape of bone defects.
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Description

technical field

[0001] The invention relates to the field of bioengineering, in particular to a preparation method of nano pearl powder / C-HA composite scaffold. Background technique

[0002] Bone defects have become a global health problem. With the aging of the population and the development of society, the repair of bone defects has become an important clinical topic and social demand. At present, the clinical treatment of bone defects mainly relies on allogeneic bone grafting or autologous bone grafting, but there are many limitations in these two treatment methods. For a long time, autologous bone transplantation has been recognized as the gold standard of bone transplantation, but there are disadvantages such as limited amount of available bone, complications at the donor site, and easy absorption of transplanted bone blocks; allogeneic bone transplantation has immune rejection and transmission of infectious diseases risks of.

[0003] With the development of medicin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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