Selenium-containing macromolecular fluorescent probe and preparation method thereof

A technology of fluorescent probes and macromolecules, applied in fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problems of selenium-containing small molecule fluorescent probes such as water solubility and poor stability
CN107325211BActive Publication Date: 2019-04-26SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2019-04-26

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Abstract

The invention relates to a preparation method for a selenium-containing macromolecule fluorescence probe. The method comprises the following steps: enabling o-position halogenated benzaldehyde and sodium diselenide to react in an organic solvent at 90-120 DEG C, thereby acquiring 2,2'-diphenyl diselenide; enabling 2,2'-diphenyl diselenide to react with 2,4-dimethyl pyrrole under an effect of catalyst, adding an oxidizing agent for continuing reacting, adding organic alkali and a complexing agent and reacting at 20-40 DEG C, thereby acquiring 2,2'-difluoro boron pyrrole diphenyl diselenide; performing free radical polymerization reaction on 2,2'-difluoro boron pyrrole diphenyl diselenide and a compound containing double bond at 20-70 DEG C, thereby acquiring the selenium-containing macromolecule fluorescence probe. The invention also discloses the selenium-containing macromolecule fluorescence probe prepared according to the method. According to the method provided by the invention, the selenium-containing diselenide is firstly prepared and then is utilized to regulate the polymerization of monomer, so that the selenium-containing macromolecule fluorescence probe can be acquired. The selenium-containing macromolecule fluorescence probe can be used for detecting oxides.
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Description

technical field

[0001] The invention relates to the field of organic chemical synthesis, in particular to a selenium-containing macromolecular fluorescent probe and a preparation method thereof. Background technique

[0002] During the process of aerobic respiration, organisms will produce a variety of active oxygen free radicals, which will produce corresponding physiological and pathological effects. Within a controllable range, active oxygen free radicals can interact with reduced substances to regulate cell signal transmission. If the content of these active oxygen free radicals is out of control, it will cause damage to proteins, lipids, and nucleic acids, and may cause various diseases. Due to the short half-life of active oxygen free radicals, the concentration in physical strength is very low, so real-time detection of the level of active oxygen free radicals in biological systems has become the research focus of scientists. The fluorescence detection method of rea...

Claims

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