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A preparation method and application of collagen peptide chelated calcium microspheres

A collagen peptide and fish skin collagen technology, which is applied in the preparation methods of peptides, chemical instruments and methods, animal/human proteins, etc., can solve the problems of decreased activity and calcium supplementation effect, etc., and achieves easy separation and improved absorption. rate, stable performance

Active Publication Date: 2021-05-11
青岛海时代生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with traditional calcium supplements, collagen peptide chelated calcium has a higher absorption and utilization rate; however, due to the variety of enzymes and complex environments in the human stomach and intestines, the existing collagen peptide chelated calcium is digested by the gastrointestinal tract. The activity decreases, and the effect of calcium supplementation is significantly reduced; therefore, it is necessary to develop a technology that can protect collagen peptide chelated calcium, especially collagen peptide chelated calcium microspheres that can be specifically released in the distal ileum

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Take fish skin collagen peptides with a molecular weight distribution range of ≤2000D, prepare a 0.5% (g / 100mL) fish skin collagen peptide solution, and add 0.1% Ca(OH) 2 (g / 100mL) solution to adjust the pH of the fish skin collagen peptide solution to 7.0-8.0, add 0.6% CaCl to the fish skin collagen peptide solution 2 (g / 100mL), the added CaCl 2 The volume ratio of the solution to the collagen peptide solution is 0.7; stir and react at 37°C for 60 minutes to obtain a collagen peptide chelated calcium solution, pass through a nanofiltration membrane with a molecular weight cut-off of 200, and freeze-dry the concentrated solution for later use. The mass fraction of calcium in the collagen peptide chelated calcium is 6.95%.

[0022] (2) Prepare the collagen peptide chelated calcium prepared in step (1) into a 6% (g / 100mL) solution, then prepare a mixed solution with a 3% (g / 100mL) sodium alginate solution, stir evenly, and let stand to remove bubble.

[0023] Weigh...

Embodiment 2

[0025] (1) Take fish skin collagen peptides with a molecular weight distribution range of ≤2000D, prepare a 0.5% (g / 100mL) fish skin collagen peptide solution, and add 0.1% Ca(OH) 2 (g / 100mL) to adjust the pH of the fish skin collagen peptide solution to 7.0-8.0, add 0.6% (g / 100mL) CaCl 2 solution, the added CaCl 2 The volume ratio of the solution to the collagen peptide solution was 1.4, stirred and reacted at 37°C for 60 minutes, the collagen peptide chelated calcium solution was passed through a nanofiltration membrane with a molecular weight cut-off of 200, and the concentrated solution was freeze-dried for later use. The mass fraction of calcium in the collagen peptide chelated calcium is 7.18%.

[0026] (2) Configure the collagen peptide chelated calcium prepared in step (1) into a 4% (g / 100mL) solution, then prepare a mixed solution with 2% (g / 100mL) sodium alginate solution, stir evenly, and let stand to remove bubble.

[0027] Weigh ultrafine CaCO 3 In deionized w...

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Abstract

The invention provides a preparation method and application of collagen peptide chelated calcium microspheres, belonging to the field of marine biological products, adding CaCl to fish skin collagen solution 2 solution to obtain a collagen peptide chelated calcium solution; the prepared collagen peptide chelated calcium solution and sodium alginate solution were formulated into a mixed solution at a volume ratio of 1:1, and CaCO 3 The suspension was mixed with the mixed solution, and after stirring evenly, it was dropped into the newly prepared D-gluconolactone solution drop by drop with a stainless steel needle, and stirred until a uniform sol was formed; the microspheres were washed and filtered with distilled water, and finally used The filter paper absorbs the moisture on the surface of the microspheres and dries to obtain the microspheres. The microspheres prepared by the present invention hardly swell when passing through the mouth and stomach, but begin to swell when passing through the slightly alkaline distal ileum, and specifically release a collagen peptide to chelate calcium in a short period of time. Chelated calcium is easily absorbed by small intestinal epithelial cells, significantly improving the absorption rate of calcium.

Description

technical field [0001] The invention belongs to the field of marine biological products, and in particular relates to a preparation method and application of collagen peptide chelated calcium microspheres. Background technique [0002] Fish skin is rich in collagen, and the collagen peptide prepared from fish skin has good biocompatibility, biodegradability and weak antigenicity, and has a wide range of biological activities, such as anti-oxidation, antibacterial , lipid-lowering activity and beneficial to wound healing, skin, bone and joints, widely used in food, pharmaceutical and cosmetic industries. [0003] Calcium is one of the essential mineral elements for the human body and participates in various physiological activities of the body. Calcium deficiency seriously endangers human health. The absorption of calcium ions in the small intestine, except for a small part (15-20% by weight) in the front part of the duodenum requires the active transport of vitamin D, most ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/78C07K1/107A23L33/165A23L33/18
Inventor 赵玲刘淇曹荣孙慧慧
Owner 青岛海时代生物工程有限公司
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