Anti-bioadhesive material, preparation method thereof and metal instrument coated with the same

An adhesive material and anti-biological technology, applied in coatings, medical science, surgery, etc., can solve problems such as cumbersome polymerization reactions, and achieve the effects of good biocompatibility, high stability, and broad market application prospects

Inactive Publication Date: 2018-02-02
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this feature is usually only used for the preparation of immobilized dopamine-based initiators or initiating syste

Method used

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  • Anti-bioadhesive material, preparation method thereof and metal instrument coated with the same
  • Anti-bioadhesive material, preparation method thereof and metal instrument coated with the same
  • Anti-bioadhesive material, preparation method thereof and metal instrument coated with the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) The preparation method of anti-bioadhesion material is:

[0042] Under the protection of argon, (0.75mmol) sulfonamide zwitterionic monomer (n=2, m=3, R: methacrylate type) and (6.75mmol) phosphonic acid monomer (n=1, R 1 : H, R 2 : methacrylate type) was dissolved in water at a molar ratio of 1:9, then potassium persulfate (APS) (0.5 mmol) and tetramethylethylenediamine (TEMED) (11.25 μL) were added to the reaction system, and the Mix evenly and react at room temperature for 24 hours. The product is precipitated by methanol to obtain a white polymer. The polymer is vacuum-dried at room temperature to prepare a zwitterion / phosphonic acid copolymer with a molecular weight of 99,000 and a molecular weight dispersion coefficient of 2.7.

[0043] Sulfonium ammonium:

[0044] Phosphonic acid:

[0045] (2) The preparation method of the anti-bioadhesion titanium alloy material is:

[0046] Dissolve the copolymer prepared in step (1) in sterile PBS to prepare a 50 m...

Embodiment 2

[0048] (1) The preparation method of anti-bioadhesion material is:

[0049]Under nitrogen protection, (1 mmol) ammonium phosphate zwitterionic monomer (n=3, m=4, R: acrylate type) was dissolved in methanol (10 mL), and then ethyl 2-bromoisobutyrate (0.2 mmol), cuprous bromide (0.2mmol) / bipyridine (0.4mmol) were added to the reaction system, and after uniform mixing, they were reacted at 37°C for 12h, and the white polymer after precipitation with ether was vacuum-dried at room temperature to obtain Zwitterionic homopolymer. In the obtained zwitterionic homopolymer, add 39mmol phosphonic acid monomer, with phosphonic acid monomer (n=3, R 1 : H, R 2 : styrene type) as polymerized monomers, with zwitterionic homopolymer as macroinitiator (the mol ratio of phosphonic acid monomer and the ammonium phosphate zwitterionic monomer used to prepare homopolymer is 97.5: 2.5), through and Preparation of Zwitterionic Homopolymer Under the same polymerization conditions (monomer concentr...

Embodiment 3

[0055] (1) The preparation method of anti-bioadhesion material is:

[0056] Under the protection of argon, the carboxyammonium zwitterionic monomer (n=3, m=5, R: methacrylamide ester type) was dissolved in trifluoroethanol, and azobisisobutyronitrile, 2-cyano Base-2-propylbenzodisulfide is added to the reaction system (the molar ratio of each substance is carboxyammonium zwitterionic monomer: azobisisobutyronitrile: 2-cyano-2-propylbenzodisulfide=50: 1:1), mixed uniformly and reacted at 60°C for 24 hours, and the white polymer after ether precipitation was vacuum-dried at room temperature to obtain a zwitterionic homopolymer. Add phosphonate monomer in the zwitterionic homopolymer that makes, with phosphonate monomer (n=4, R 1 :OCH 2 CH 3 , R 2 : Vinyl type) is polymerized monomer, with zwitterionic homopolymer as macromolecular chain transfer agent (the molar ratio of phosphonate monomer and carboxyammonium zwitterionic monomer used for preparing homopolymer is 1:1), The...

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Abstract

The invention provides an anti-bioadhesive material, which is a copolymer formed by copolymerization of a zwitterionic monomer and a phosphonic acid or phosphonate monomer. On the other hand, the invention also provides a preparation method of the anti-bioadhesive material. The method includes: directly mixing the zwitterionic monomer with the phosphonic acid or phosphonate monomer for copolymerization, or firstly preparing a homopolymer of one of the two monomers, then adopting the prepared homopolymer as the macroinitiator or chain transfer agent, and taking the other monomer of the two monomers as the polymerization monomer to prepare a copolymer of the zwitterionic monomer and the phosphonic acid or phosphonate monomer. The invention also provides an anti-bioadhesive metal instrument,the surface of which is provided with a coating of the anti-bioadhesive material. The anti-bioadhesive material has high stability, and by means of a simple coating process, a stable polymer coating can form on the metal surface, an anti-bioadhesive material surface modified metal surface protein has significantly reduced nonspecific adsorption performance, and the anti-bioadhesive performance issignificantly improved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an anti-bioadhesion material, a preparation method thereof, and a metal device coated with the anti-bioadhesion material. technical background [0002] Metal materials are widely used in the field of biomedicine because of their high mechanical strength, machinability, and certain biocompatibility. However, the inherent bioinertness of metal materials and the lack of effective anti-bioadhesive properties (anti-inflammatory, antibacterial, anticoagulant, etc.) can easily lead to immune reactions, causing postoperative infection and thrombosis, which greatly reduces the use of metal materials to prepare implants. Biosafety performance of type devices. Therefore, constructing an efficient anti-bioadhesion coating on the surface of implantable metal devices has always been a hot and difficult point in the modification of metal devices. [0003] Surface modification i...

Claims

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Application Information

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IPC IPC(8): C08F230/02C08F220/38C08F120/36C08F265/04C08F226/02C08F130/02C08F275/00A61L31/14A61L31/10A61L31/02
CPCA61L31/022A61L31/10A61L31/14A61L2420/02C08F120/36C08F130/02C08F220/365C08F226/02C08F230/02C08F265/04C08F275/00C08F220/385
Inventor 沈健刘平生刘红伟
Owner NANJING NORMAL UNIVERSITY
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