Silver/cationic copolymer modified nano-diamond composite particle and preparation method thereof

A cationic copolymer, nanodiamond technology, applied in the fields of botanical equipment and methods, chemicals for biological control, biocides, etc., can solve the problem that Ag nanoparticles are easy to fall off, the particle size distribution is limited, and the antibacterial ability is insufficient. and other problems, to avoid the loss of macromolecules, fast and excellent antibacterial effect, and excellent antibacterial performance.

Inactive Publication Date: 2018-02-23
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Existing research uses the simple physical mixing of nano-diamonds and antibacterial agents as nano-antibacterial materials. Among them, the nano-diamonds mixed directly without treatment have limited their ability to strengthen and toughen due to their large particle size and wide particle size distribution. abi...

Method used

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  • Silver/cationic copolymer modified nano-diamond composite particle and preparation method thereof
  • Silver/cationic copolymer modified nano-diamond composite particle and preparation method thereof
  • Silver/cationic copolymer modified nano-diamond composite particle and preparation method thereof

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preparation example Construction

[0035] The preparation method of silver / cationic copolymer modified nano-diamond composite particle comprises the following steps:

[0036] a. Preparation of PVP-co-HEMA: Azobisisobutyronitrile (AIBN) was used as a thermal initiator, 4-vinylpyridine and hydroxyethyl methacrylate were mixed, heated and stirred, and the resulting mixture was precipitated in hexane three times and dried in vacuo.

[0037] b. ND was reacted with bromopropyltrimethoxysilane in aqueous alcohol solution, and the product (BrND) was centrifuged, washed and dried.

[0038] c.BrND reacts with PVP-co-HEMA in ethanol, and add excess hexyl bromide to fully quaternize PVP-co-HEMA, the product (QND) is centrifuged, washed, dried, and quaternized by adding excess hexyl bromide The degree is improved, the dispersibility of ND and the antibacterial performance of cationic polymer are improved.

[0039] d. Disperse the QND prepared above in distilled water and mix with AgNO 3 The aqueous solution is mixed and b...

Embodiment 1

[0041] Step a: Azobisisobutyronitrile AIBN is used as a thermal initiator to synthesize a copolymer by free radical polymerization. The molar ratio of 4-vinylpyridine monomer to hydroxyethyl methacrylate is 70 / 30. The mixture was stirred and heated in an oil bath at 60°C for 24 hours. Finally, the reaction mixture was precipitated three times in hexane and dried in a vacuum oven to obtain a pale yellow product.

[0042] Step b: Weigh raw material ND100mg and add to 20mL alcohol aqueous solution (V 乙醇 :V 水 =9:1), then add silane coupling agent (bromopropyltrimethoxysilane) according to 10% (10mg) of ND mass, stir magnetically at 50°C for 24h, centrifuge the product, wash three times with deionized water, Dry in a vacuum oven at 60°C.

[0043]Step c: Dissolve 50mg BrND in 20ml ethanol solution, add 50mg copolymer PVP-co-HEMA, react at 70°C for 24h, then add excess bromide hexane (0.12g) to make it fully quaternized, centrifuge the product, and use Washed three times with et...

Embodiment 2

[0053] Step a: The molar ratio of 4-vinylpyridine monomer to hydroxyethyl methacrylate is 95 / 5.

[0054] Step d: Mass ratio, nano-diamond: silver nitrate: sodium citrate = 1: 1.2: 1.4, keep the solution boiling for 1 h.

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Abstract

The invention discloses a silver/cationic copolymer modified nano diamond composite particle and a preparation method thereof. The composite particle is obtained by using a copolymer to modify alkylated nano diamond, and then loading nano silver onto the surface of the nano diamond, wherein the copolymer is a product produced by copolymerization of 4-vinylpyridine and hydroxyethyl methylacrylate.An antibacterial agent has better inhibiting and killing effects for gram negative bacteria (escherichia coli) and gram positive bacteria (staphylococcus aureus), the corresponding minimum inhibitoryconcentrations are respectively 50mug/mL and 25mug/mL, the inhibition zone is obvious and the 90-minute sterilization rate for the escherichia coli reaches 100%. As an additive, the antibacterial agent prepared by the invention can be added into certain medical composite materials to be used in the fields of plastic surgery, osteosynthesis and/or endoprothesis and the like, and especially under the condition with high infection risk, the antibacterial agent has the advantages that the mechanical property can be enhanced, simultaneously excellent antibacterial property is endowed, the service life of medical instruments can be prolonged and the infection risk to patients is reduced.

Description

technical field [0001] The invention belongs to the field of antibacterial agent synthesis and relates to a medical composite material, in particular to a silver / cation copolymer modified nano-diamond composite particle and a preparation method thereof. Background technique [0002] How to effectively prevent and treat post-operative infection has always attracted attention. The traditional method of treating bacterial infection is through injection or oral antibiotics. However, with the emergence of drug-resistant bacteria, the cure rate of traditional antibiotic therapy is decreasing year by year. In recent years, nano-antibacterial agents have been extensively studied by researchers as a new way to treat drug-resistant bacterial infections. Jang et al. (non-patent literature) prepared silica nanoparticles modified with small molecule quaternary ammonium salts, which greatly improved the antibacterial efficiency of quaternary ammonium salts, and their antibacterial proper...

Claims

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Application Information

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IPC IPC(8): A01N25/08A01N43/40A01N59/16A01P1/00A01P3/00
CPCA01N25/08A01N43/40A01N59/16
Inventor 吴宇轩曹巍巍胡月吴娜邢晓东李强
Owner NANJING UNIV OF SCI & TECH
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