Silver/cationic copolymer modified nano-diamond composite particle and preparation method thereof

Abstract

The invention discloses a silver / cationic copolymer modified nano diamond composite particle and a preparation method thereof. The composite particle is obtained by using a copolymer to modify alkylated nano diamond, and then loading nano silver onto the surface of the nano diamond, wherein the copolymer is a product produced by copolymerization of 4-vinylpyridine and hydroxyethyl methylacrylate.An antibacterial agent has better inhibiting and killing effects for gram negative bacteria (escherichia coli) and gram positive bacteria (staphylococcus aureus), the corresponding minimum inhibitoryconcentrations are respectively 50mug / mL and 25mug / mL, the inhibition zone is obvious and the 90-minute sterilization rate for the escherichia coli reaches 100%. As an additive, the antibacterial agent prepared by the invention can be added into certain medical composite materials to be used in the fields of plastic surgery, osteosynthesis and / or endoprothesis and the like, and especially under the condition with high infection risk, the antibacterial agent has the advantages that the mechanical property can be enhanced, simultaneously excellent antibacterial property is endowed, the service life of medical instruments can be prolonged and the infection risk to patients is reduced.

Description

technical field [0001] The invention belongs to the field of antibacterial agent synthesis and relates to a medical composite material, in particular to a silver / cation copolymer modified nano-diamond composite particle and a preparation method thereof. Background technique [0002] How to effectively prevent and treat post-operative infection has always attracted attention. The traditional method of treating bacterial infection is through injection or oral antibiotics. However, with the emergence of drug-resistant bacteria, the cure rate of traditional antibiotic therapy is decreasing year by year. In recent years, nano-antibacterial agents have been extensively studied by researchers as a new way to treat drug-resistant bacterial infections. Jang et al. (non-patent literature) prepared silica nanoparticles modified with small molecule quaternary ammonium salts, which greatly improved the antibacterial efficiency of quaternary ammonium salts, and their antibacterial proper...

AI Technical Summary

Problems solved by technology

[0004] Existing research uses the simple physical mixing of nano-diamonds and antibacterial agents as nano-antibacterial materials. Among them, the nano-diamonds mixed directly without treatment have limited their ability to strengthen and toughen due to their large particle size and wide particle size distribution. ability

On the other hand, Ag is mostly directly deposited on porous materials such as fabrics and dressings, so the Ag nanoparticles obtained in this way inevitably have the problem of being easy to fall off, and the antibacterial ability of nano-silver antibacterial agents against Gram-positive bacteria is relatively insufficient

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