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Modified sodium alginate electrospun fibre hemostatic membrane and preparation method thereof

A technology of sodium alginate and electrospun fibers, which is applied in the fields of pharmaceutical formula, medical science, and absorbent pads, etc., can solve the problems of single molding method and limited application of hemostatic materials, so as to broaden the application range, improve soft compressibility, reduce Effects on discomfort and pain

Inactive Publication Date: 2018-02-27
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sodium alginate solution by Ca 2+ Cross-linking forms calcium alginate gel, which releases Ca during coagulation 2+ , and Na in blood + It can be exchanged to promote hemostasis. In addition, sodium alginate also has high water absorption and moisturizing properties, antibacterial and bactericidal properties, and can be used as medical dressings. Sodium alginate medical dressings can not only absorb wound exudate, but also can Form a gel film on the wound surface, provide a suitable moist physiological microenvironment for wound healing, and reduce bacterial infection at the wound site, but the formation method of sodium alginate is single, which limits its application in the preparation of hemostatic materials

Method used

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  • Modified sodium alginate electrospun fibre hemostatic membrane and preparation method thereof
  • Modified sodium alginate electrospun fibre hemostatic membrane and preparation method thereof
  • Modified sodium alginate electrospun fibre hemostatic membrane and preparation method thereof

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preparation example Construction

[0032] (1) Preparation of thiolated sodium alginate

[0033] Weigh a certain mass of sodium alginate and dissolve it in distilled water to prepare a sodium alginate solution with a mass concentration of 2%, then add a sodium hydroxide solution with a molar concentration of 2mol / L to adjust the pH of the sodium alginate solution to 4, and then press Mass ratio sodium alginate: N-hydroxysuccinimide (NHS): 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC)=1:0.1:0.2 added N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, stirred at room temperature for 2h, and then according to the mass ratio of sodium alginate: cysteine ​​methyl ester Hydrochloride=1:1 Add cysteine ​​methyl ester hydrochloride, stir at room temperature for 12 hours, then add a large amount of absolute ethanol to precipitate the reaction product, filter with suction, and then wash with absolute ethanol 2-3 times, 45 °C and vacuum-dried to obtain mercaptolated so...

Embodiment 1

[0042] According to the present invention, a modified sodium alginate electrospun fiber hemostatic membrane is prepared according to the above method, wherein: the molecular weight of the polyvinyl alcohol used in the preparation process is 80000, and the molecular weight of the sodium alginate used is 1 × 10 6 kDa; The electrospinning machine used is the TL-192 electrospinning machine produced by Shenzhen Tongli Micro-Nano Co., Ltd. The parameters of the outer fiber film spinning are set as follows: high-voltage power supply voltage: 18kV, winding device rotation speed: 2000 rpm , output pump flow rate: 75 mL / h; the parameters of inner layer composite fiber membrane spinning are set as follows: high voltage power supply voltage 22 kV, winding device rotation speed: 1000 rpm, output pump flow rate: 50 mL / h; calculated by weight parts It is composed of 10 parts of polyvinyl alcohol and 5 parts of thiolated alginic acid.

Embodiment 2

[0044] According to the present invention, a modified sodium alginate electrospun fiber hemostatic membrane is prepared according to the above method, wherein: the molecular weight of the polyvinyl alcohol used in the preparation process is 80000, and the molecular weight of the sodium alginate used is 1 × 10 6 kDa; The electrospinning machine used is the TL-192 electrospinning machine produced by Shenzhen Tongli Micro-Nano Co., Ltd. The parameters of the outer fiber film spinning are set as follows: high-voltage power supply voltage: 18kV, winding device rotation speed: 2000 rpm , output pump flow rate: 100 mL / h; the parameters of inner layer composite fiber membrane spinning are set as follows: high voltage power supply voltage: 22kV, winding device rotation speed: 1500 rpm, output pump flow rate: 75 mL / h; by weight parts It consists of 20 parts of polyvinyl alcohol and 10 parts of thiolated alginic acid.

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Abstract

The invention belongs to the technical field of medical apparatus and instruments, and discloses a modified sodium alginate electrospun fibre hemostatic membrane and a preparation method thereof. Themodified sodium alginate electrospun fibre hemostatic membrane is prepared from the following components in parts by weight: 10 to 30 parts of polyvinyl alcohol and 5 to 15 parts of sulfhydrated alginate. According to the modified sodium alginate electrospun fibre hemostatic membrane and the preparation method thereof, the electrospun fibre membrane material prepared by performing electrospinningon the polyvinyl alcohol and the sulfhydrated alginate serving as raw materials is of a porous structure; the soft compressibility and the water absorbability of the material can be improved; space isprovided for adhesion and aggregation of blood platelets. The softness can expand the application range of a hemostatic material and reduce discomfort and pain; the improvement of the water absorbability can quickly absorb moisture in blood and increase the viscosity of the blood, so that the blood flow speed is reduced and the blood is coagulated; the increment of a blood platelet adhesion spaceis beneficial to aggregation of a large number of the blood platelets in a short time and activating blood coagulation factors to stop bleeding quickly.

Description

technical field [0001] The invention belongs to the field of medical device preparation, in particular to a modified sodium alginate electrospun fiber hemostatic membrane and a preparation method thereof. Background technique [0002] At present, the death caused by blood loss accounts for a considerable proportion of sudden death in life. In the process of wound first aid and surgical operation, there is also the problem of wound bleeding, and cases of medical accidents and even death caused by severe bleeding abound. In short, rapid and effective hemostasis has become one of the key factors for the success of saving lives, and it is also one of the cores for the success of surgical operations. Therefore, effective control of bleeding volume, reduction of bleeding time, and reduction of wound infection have become important factors in reducing mortality. [0003] In order to achieve a more efficient hemostatic effect, new hemostatic materials prepared by combining medical...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/20A61L15/28A61L15/24
CPCA61L15/20A61L15/225A61L15/42A61L15/425A61L2400/04C08L5/04C08L29/04
Inventor 韦加娜陈锦涛陈泰瀛
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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