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Cancellous bone structure simulating artificial bone having ultra-low elasticity modulus and preparation method of artificial bone

A technology of elastic modulus and cancellous bone, which is applied in the fields of pharmaceutical formulation, medical science, tissue regeneration, etc., can solve the problems of poor direct bonding ability, achieve dense coating, induce osteogenesis effect, and promote deposition and growth Effect

Inactive Publication Date: 2018-04-13
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Titanium-based alloys are generally considered to be bioinert materials due to their poor ability to directly bond with surrounding bone tissue due to the natural passive film on the surface

Method used

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  • Cancellous bone structure simulating artificial bone having ultra-low elasticity modulus and preparation method of artificial bone
  • Cancellous bone structure simulating artificial bone having ultra-low elasticity modulus and preparation method of artificial bone
  • Cancellous bone structure simulating artificial bone having ultra-low elasticity modulus and preparation method of artificial bone

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Experimental program
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Effect test

Embodiment 1

[0032] (1) First select 10mm×10mm×10mm polymer foam, 70 g titanium, 25 g niobium, 20 g zirconium, 40 g water, 5 g gelatin and vacuum ball mill for 5 hours;

[0033] (2) The scaffold is first treated at 300°C for 3 hours; then sintered at 1350°C in vacuum for 3 hours to obtain artificial bones, such as figure 1 shown;

[0034] (3) Use sodium hydroxide aqueous solution with a concentration of 5mol / L to carry out hydrothermal reaction, the working temperature is 100°C, and the treatment time is 12 hours to obtain an artificial bone with a porous sodium titanate coating, such as figure 2 and image 3 shown;

[0035] (4) Soak the obtained artificial bone in simulated body fluid, the temperature is controlled at 37±0.5°C, and the soaking time is 30 days to obtain the artificial bone coated with hydroxyapatite composite sodium titanate, such as Figure 4 shown;

[0036] (5) Take out the above-mentioned artificial bone, wash it with alcohol and deionized water, dry it, store it a...

Embodiment 2

[0038] (1) First select 10mm×10mm×10mm polymer foam, 70 g titanium, 25 g niobium, 20 g zirconium, 40 g water, 5 g gelatin and vacuum ball mill for 5 hours;

[0039] (2) The scaffold is first treated at 400°C for 3 hours; then sintered at 1300°C in vacuum for 3 hours to obtain an artificial bone;

[0040] (3) Using a sodium hydroxide aqueous solution with a concentration of 5mol / L for hydrothermal reaction, the working temperature is 100°C, and the treatment time is 12h, and the artificial bone is coated with porous sodium titanate;

[0041] (4) Soak the obtained artificial bone in simulated body fluid, the temperature is controlled at 37±0.5°C, and the soaking time is 40 days to obtain the artificial bone coated with hydroxyapatite composite sodium titanate;

[0042](5) Take out the above-mentioned artificial bone, wash it with alcohol and deionized water, dry it, store it aseptically after disinfection, and keep it for later use, then the artificial bone with imitation cancel...

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Abstract

The invention relates to a cancellous bone structure simulating artificial bone having ultra-low elasticity modulus and a preparation method of the artificial bone. The artificial bone is composed of[beta]-phase and [alpha]-phase titanium alloys and a hydroxyapatite-combined sodium titanate surface layer having a porous network nano-structure. The sodium titanate surface layer having the porous network nano-structure is combined with a metal surface and a porous network surface is generated through a hydrothermal reaction between a titanium or titanium alloy surface and a sodium hydroxide solution. The combination of hydroxyapatite is achieved by soaking in simulated body fluid. The preparation method comprises the following steps: firstly, processing compact titanium alloy artificial bone from polymer foams, titanium and other metals; then, synthesizing a sodium titanate layer having the porous network structure by virtue of an alkaline liquid hydrothermal method; soaking the obtained artificial bone in the simulated body fluid; and finally, drip washing the artificial bone by alcohol and de-ionized water, drying and disinfecting the artificial bone, and preserving the artificialbone in an sterile environment for later use.

Description

technical field [0001] The invention relates to an artificial bone imitating cancellous bone structure and ultra-low elastic modulus and its preparation method, in particular to an artificial bone composed of titanium or titanium alloy artificial bone and hydroxyapatite composite porous network structure sodium titanate surface layer The artificial bone and its preparation method belong to the technical field of cancellous bone replacement. Background technique [0002] Cancellous bone is a porous network composed of rods and plate-like trabeculae. Due to its unique porous structure, it has great advantages in the human body, such as rapid vascularization, bone growth, etc. However, damage to cancellous bone is mostly due to trauma, disease, or surgery. The repair of bone defects is a new challenge for surgeons, but there are still difficulties due to the selection of materials, fabrication methods, and biocompatibility. [0003] Titanium and its alloys are known as one o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/32A61L27/30A61L27/54A61L27/56
CPCA61L27/06A61L27/306A61L27/32A61L27/54A61L27/56A61L2300/102A61L2300/606A61L2400/08A61L2420/08A61L2430/02
Inventor 饶席杨济涵谭小东
Owner SOUTHWEST UNIV
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